Association analysis of miRNA-146a and miRNA-499 polymorphisms with rheumatoid arthritis: a case–control and trio-family study

Islam, Zia Ul; Baneen, Umul; Khaliq, Taqdees; Nurulain, Syed M.; Muneer, Zahid; Hussain, Shahzad

doi:10.1007/s10238-022-00916-y

Cited by 4 publications

(5 citation statements)

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“…The present study's findings indicate an association between miRNA‐146a (rs2910164; C>G) and miRNA‐499 (rs3746444; T>C) polymorphisms with RA among the examined population. Moreover, our study revealed, for the first time in our high‐risk population, a significant association between the rs2910164 G allele and the rs3746444 C allele and familial RA 205 …”

Section: Mirna Based Targeted Therapeutics In Adssupporting

confidence: 55%

“…Moreover, our study revealed, for the first time in our high-risk population, a significant association between the rs2910164 G allele and the rs3746444 C allele and familial RA. 205 Type-I diabetes (TID) is the most common AD, leading to the selective destruction of islet β cells by the body's immune cells. Therefore, miRNAs such as miRNA-142-3p, miRNA-142-5p, and miRNA-155 from human T lymphocyte exosomes have been deployed to form β cells favoring apoptosis, cellular differentiation, and cell growth.…”

Section: Mirna Based Targeted Therapeutics In Adsmentioning

confidence: 99%

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Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

Nag,

Mitra,

Tripathi

et al. 2023

Immunity Inflam & Disease

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BackgroundAutoimmune diseases (AD) are severe pathophysiological ailments that are stimulated by an exaggerated immunogenic response towards self‐antigens, which can cause systemic or site‐specific organ damage. An array of complex genetic and epigenetic facets majorly contributes to the progression of AD, thus providing significant insight into the regulatory mechanism of microRNA (miRNA). miRNAs are short, non‐coding RNAs that have been identified as essential contributors to the post‐transcriptional regulation of host genome expression and as crucial regulators of a myriad of biological processes such as immune homeostasis, T helper cell differentiation, central and peripheral tolerance, and immune cell development.AimsThis article tends to deliberate and conceptualize the brief pathogenesis and pertinent epigenetic regulatory mechanism as well as miRNA networks majorly affecting five different ADs namely rheumatoid arthritis (RA), type 1 diabetes, multiple sclerosis (MS), systemic lupus erythematosus (SLE) and inflammatory bowel disorder (IBD) thereby providing novel miRNA‐based theranostic interventions.Results & DiscussionPertaining to the differential expression of miRNA attributed in target tissues and cellular bodies of innate and adaptive immunity, a paradigm of scientific expeditions suggests an optimistic correlation between immunogenic dysfunction and miRNA alterations.ConclusionTherefore, it is not astonishing that dysregulations in miRNA expression patterns are now recognized in a wide spectrum of disorders, establishing themselves as potential biomarkers and therapeutic targets. Owing to its theranostic potencies, miRNA targets have been widely utilized in the development of biosensors and other therapeutic molecules originating from the same.

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Section: Mirna Based Targeted Therapeutics In Adssupporting

confidence: 55%

Section: Mirna Based Targeted Therapeutics In Adsmentioning

confidence: 99%

Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

Nag,

Mitra,

Tripathi

et al. 2023

Immunity Inflam & Disease

View full text Add to dashboard Cite

show abstract

“…16 Moreover, its level is positively associated with RA disease activity and TNF-α level. 32,33 Multiple studies have also examined the association of miRNA-146a polymorphism rs2910164 with RA, [11][12][13][14][15][16][17] and some of these studies have suggested that miRNA-146a polymorphism rs2910164 may be involved in the initiation and progression of RA. MiRNA-146a can halt excess inflammation via a negative feedback mechanism in RA.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, multiple studies have examined the association of miRNA-146a polymorphism rs2910164 with RA. [11][12][13][14][15][16][17] Additionally, the expression of miRNA-223 is also significantly up-regulated in synovial fluid, fibroblast-like synoviocytes and naive CD4+T lymphocytes of RA patients compared with healthy and disease (osteoarthritis) controls. [18][19][20] However, the independent associations of miRNA-146a and miRNA-223 with RA have still not been investigated, as well as their predictive values for RA.…”

Section: Introductionmentioning

confidence: 99%

Associations of miRNA-146a and miRNA-223 with Rheumatoid Arthritis and Their Predictive Values

Zhang,

Shang,

Wang

et al. 2023

IJGM

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To analyze the independent associations of miRNA-146a and miRNA-223 with rheumatoid arthritis (RA) and evaluate their predictive values for RA. Patients and Methods: A total of 68 RA patients were selected as cases, and meanwhile 68 patients with a traumatic knee condition were selected as controls by matching to the cases according to sex and age at the ratio of 1:1. The independent associations of miRNA-146a and miRNA-223 with RA were identified by binary logistic regression analysis. Receiver operating characteristic (ROC) curve was used to evaluate their predictive values for RA. Results: MiRNA-146a and miRNA-223 expression levels in both synovial tissues and serums were statistically higher in cases than in controls, and their expression levels in serums were not statistically different from those in synovial tissues in both cases and controls. The expression levels of miRNA-146a and miRNA-223 in synovial tissues were independently associated with RA, as well as the expression levels of miRNA-146a and miRNA-223 in serums. The area under curve (AUC) of combination of miRNA-146a and miRNA-223 in synovial tissues for the prediction of RA was 0.910 [95% confidence interval (CI): 0.863-0.962], and the AUC of combination of miRNA-146a and miRNA-223 in serums was 0.904 (95% CI: 0.851-0.957). Their difference was not statistically significant (P=0.873), but the AUC of combination prediction was statistically higher than those of individual predictions (synovial tissues: 0.910 vs 0.773, P=0.005, 0.910 vs 0.788, P=0.009; serums: 0.904 vs 0.766, P=0.005, 0.904 vs 0.784, P=0.011). Conclusion: MiRNA-146a and miRNA-223 in both synovial tissues and serums could be applied in predicting RA, and their combination could elevate the predictive value significantly.

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“…The mechanisms of miRNA-mediated gene expression include translational repression, mRNA cleavage, post-transcriptional regulation through binding to 3′-untranslated regions (3′-UTRs) of target RNAs [ 9 , 12 , 13 ]. The aberrant expression or dysfunction of miRNAs has been extensively documented to be associated with the pathogenesis and advancement of numerous human diseases, such as diabetes [ 14 ], depressive disorder [ 15 ], rheumatoid arthritis [ 16 ], among others. Of particular significance is the involvement of miRNAs in cancer, with multiple miRNAs identified as either tumor suppressors or tumor promoters [ 4 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

MiRNA-423 rs6505162 and miRNA-6811 rs2292879 SNP associated with lung cancer in Hainan, China

Zhou,

Meng,

et al. 2023

Bioscience Reports

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Background: MicroRNAs (miRNAs) are known to exert significant influence on various physiological processes and diseases, including cancers. The primary objective of this present study was to examine the impact of eight single-nucleotide polymorphisms (SNPs) in miRNA on the susceptibility to lung cancer (LC) within the Chinese Southern population. Methods: The genotypes of these eight polymorphisms were determined in 132 LC patients and 214 cancer-free controls. Results: In overall analyses, GG genotype of miRNA-6811 rs2292879 polymorphism was significantly correlated with increased risk of LC (GG vs. AA, adjusted OR = 5.10, 95% CI = 1.02–25.43, P=0.047), yet the genotype frequencies of rs2292879 SNP in controls did not met the Hardy–Weinberg equilibrium (HWE) (P=0.001) in present study. Stratified analyses by smoking revealed that miRNA-423 rs6505162 variants significantly decreased the LC risk in heterozygous (CA vs. CC, adjusted OR = 0.14, 95% CI = 0.03–0.81, P=0.028) and recessive (AA vs. CA + CC, adjusted OR = 0.17, 95% CI = 0.03–0.90, P=0.038) genetic models in smoking population. However, miRNA-196A2 rs11614913, miRNA-196A2 rs12304647, miRNA-146A rs2910164, miRNA-16-1 rs1022960, miRNA-608 rs4919510, and miRNA-27a rs895819 polymorphisms were not significantly associated with LC. Conclusion: The findings of our study indicate a potential decrease in LC risk among smokers with the miRNA-423 rs6505162 variants, while an increase in risk is associated with miRNA-6811 rs2292879 polymorphisms in the population of Southern Chinese. However, further well-designed research is necessary to fully understand the precise impact of these two SNPs on the development of LC.

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Association analysis of miRNA-146a and miRNA-499 polymorphisms with rheumatoid arthritis: a case–control and trio-family study

Cited by 4 publications

References 37 publications

Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

Associations of miRNA-146a and miRNA-223 with Rheumatoid Arthritis and Their Predictive Values

MiRNA-423 rs6505162 and miRNA-6811 rs2292879 SNP associated with lung cancer in Hainan, China

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