Association analysis of vitamin D receptor gene polymorphisms with bone mineral density in young women with Graves' disease.

Abstract

Graves' (GD) hyperthyroidism induces accelerated bone turnover that leads to decreased bone mineral density (BMD). The role of the VDR gene in predisposition to primary osteoporosis has been recognized. Recent studies show associations between the VDR gene polymorphisms and susceptibility to autoimmune diseases. Here we analyzed if VDR gene polymorphisms: BsmI, ApaI, TaqI, and FokI may predispose women with Graves' hyperthyroidism to BMD reduction or to disease development. The subjects were 75 premenopausal female Polish patients with GD and 163 healthy women. The genotyping was performed by the use of the restriction fragment length polymorphism analysis (RFLP). We studied the association of the VDR polymorphisms and their haplotypes with patients' BMD and also SNPs and haplotypes association with Graves' disease. We found a strong linkage disequilibrium for the BsmI, ApaI, and TaqI polymorphims that formed three most frequent haplotypes in Graves' women: baT (47.9%), BAt (34.9%), and bAT (16.4%). We did not show statistically significant association of analyzed VDR polymorphisms or haplotypes with decreased bone mineral density in Graves' patients. However, the presence of F allele had a weak tendency to be associated with Graves' disease (with OR=1.93; 95% CI: 0.97-3.84; p=0.058). VDR gene polymorphisms do not predict the risk of decreased BMD in Polish women with Graves'. It may be speculated that the F allele carriers of the VDR-FokI polymorphism are predisposed to Graves' disease development.

Thyroid Autoimmunity in the Context of Type 2 Diabetes Mellitus: Implications for Vitamin D

“…We hypothesized that this inconsistency might imply a role for vitamin D in light of evidence suggesting its potential link to both thyroid autoimmunity and glucose intolerance individually. In specific, it has been reported that allelic variations within the VDR gene may mediate susceptibility to thyroid autoimmunity [ 15 , 16 ]. Vitamin D insufficiency has been associated with thyroid autoimmunity [ 17 ], serum 25(OH)D levels were found to be significantly lower in patients with thyroid autoimmunity compared to controls [ 18 , 19 ], and the severity of 25(OH)D deficiency correlated with thyroid antibody levels in both adult [ 18 , 19 ] and children populations [ 20 ].…”

Dental management in children with thyroid dysfunction

“…Na skutek nadczynności tarczycy w układzie kostnym można dostrzec przyspieszenie procesów anabolicznych, jak i katabolicznych [1]. W wyniku zmienionego metabolizmu tkanki kostnej dochodzi do wzrostu liczby osteoklastów i aktywności osteoblastów, jednakże procesy resorpcji kości przeważają nad tworzeniem tkanki kostnej [10,20]. Objawy osteoporozy widoczne są w kościach wyrostków zębodołowych [1,20].…”

“…W wyniku zmienionego metabolizmu tkanki kostnej dochodzi do wzrostu liczby osteoklastów i aktywności osteoblastów, jednakże procesy resorpcji kości przeważają nad tworzeniem tkanki kostnej [10,20]. Objawy osteoporozy widoczne są w kościach wyrostków zębodołowych [1,20]. W obrazie histopatologicznym można stwierdzić zwyrodnienie ozębnej oraz zaburzenie układu oraz degenerację włókien kolagenowych, co może prowadzić do utraty zębów.…”

Pharmacogenomics in osteoporosis: Steps toward personalized medicine

“…Inadequate levels of vitamin D can lead to decreased calcium absorption and serum concentration. 12 The hormonal form of vitamin D is 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ], which bound to the vitamin D-binding protein (DBP), can be delivered to the various vitamin D target cells that use the VDR to retain the hormone. 13 The first gene identified to be associated with an osteoporosis-related phenotype was the VDR gene.…”