2009
DOI: 10.1016/j.neulet.2009.09.032
|View full text |Cite
|
Sign up to set email alerts
|

Association and expression study of synapsin III and schizophrenia

Abstract: The synapsin III gene, SYN3, which belongs to the family of synaptic vesicle-associated proteins, has been implicated in the modulation of neurotransmitter release and in synaptogenesis, suggesting a potential role in several neuropsychiatric diseases. The human SYN3 gene is located on chromosome 22q12-13, a candidate region implicated in previous linkage studies of schizophrenia. However, association studies of SYN3 and schizophrenia have produced inconsistent results. In this study, four SYN3 SNPs (rs133945(… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
12
0

Year Published

2011
2011
2017
2017

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 22 publications
(13 citation statements)
references
References 24 publications
0
12
0
Order By: Relevance
“…5d). Remarkably, those target genes are consistently found to be downregulated in the postmortem brains of schizophrenia patients [29][30][31][32][33] . Syn3, on the other hand, remained low even when endogenous miR-137 was sequestered, which suggests that additional endogenous factors modulate Syn3 levels.…”
Section: Discussionmentioning
confidence: 98%
“…5d). Remarkably, those target genes are consistently found to be downregulated in the postmortem brains of schizophrenia patients [29][30][31][32][33] . Syn3, on the other hand, remained low even when endogenous miR-137 was sequestered, which suggests that additional endogenous factors modulate Syn3 levels.…”
Section: Discussionmentioning
confidence: 98%
“…Indeed, human studies of polymorphisms in Syn3 and post-mortem Syn3 expression have sometimes implied a relationship to schizophrenia, but these results are neither consistent nor conclusive (7075). However, the Syn3 locus spans 545,839 bases and at least 3 haplotype blocks.…”
Section: Discussionmentioning
confidence: 99%
“…Vangl2 and Prickle2 also bind and promote postsynaptic clustering of PSD95, critical for maintenance of synaptic integrity [199,227,228]. Prickle1 was found to regulate synaptogenesis and synaptic vesicle trafficking through a direct interaction with synapsin1 (Syn1) [229]; the synapsin protein family have important roles in synapse formation and neurotransmitter release and have previously been implicated in the pathogenesis of psychiatric disorders [230,231,232,233,234,235,236]. Indeed, Prickle1 +/- mice exhibit ASD-like behaviors, and expression of a mutant form of Prickle in cultured cells phenocopies the vesicle trafficking defect observed with aberrant Syn1 function [229].…”
Section: Synapse Formation and Functionmentioning
confidence: 99%