Dyslipidemia is a primary risk factor for cardiovascular disease. We aim to investigate the occurrence of dyslipidemia and its associated risk factors in the southwest region of Iran. This population-based cross-sectional study was conducted on 9846 participants aged 35–70 years in southwest Iran. Information on socioeconomic factors, demographic characteristics, comorbidities, laboratory tests, anthropometric measurements, and lifestyle was collected. The criteria for dyslipidemia were based on the ATP III classification. Multiple logistic regression was used to control potential confounders. Results showed that the overall prevalence of dyslipidemia was 43.5%, with abnormal levels of HDL, LDL, TC, and TG at 17.9%, 21.8%, 36.2%, and 44%, respectively. The multiple logistic regression analysis revealed that males (OR=1.92, 95%CI: 1.74−2.14), individuals with abnormal waist circumference (OR=1.88, 95% CI: 1.67-2.12), those with low physical activity (OR=0.80, 95% CI: 0.76-0.97), smokers (OR=1.17, 95%CI: 1.05−1.31), rich people (OR=1.19, 95%CI: 1.04-1.36), and patients with hypertension (OR=1.16, 95% CI: 1.05-1.27) had higher odds of dyslipidemia. Our findings suggest that dyslipidemia is a complex condition that is influenced by various biological and lifestyle factors. Different prevention and treatment strategies may be needed for various population subgroups. Keywords: Dyslipidemia, ATP III guidelines, Adults, Population-based study.