Association between

Lee, Kyong-No; Song, Eunjin; Lee, Sukjeong; Cho, Iseop; Kim, Hyeon Ji; Park, Jee Yoon; Oh, Kyung Joon

doi:10.1071/rd22184

Cited by 3 publications

(9 citation statements)

References 33 publications

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“…Other reports on the impact of ROS on embryo quality implied that an increase in the rate of ROS in ICSI cycles is associated with an increase in the rate of embryo fragmentation (>10%) [33,[57][58][59][60][61]. However, our study showed no association between MDA levels in the embryo surrounding and embryo fragmentation.…”

Section: Discussioncontrasting

confidence: 78%

“…However, our study showed no association between MDA levels in the embryo surrounding and embryo fragmentation. Embryo fragmentation is defined by the appearance of anucleated fragments in the cytoplasm during the cleavage stage [61,62,59,63]. Although it is a common feature of IVF-derived embryos [64][65][66][67], the mechanisms and causes of embryo fragmentation are still unclear.…”

Section: Discussionmentioning

confidence: 99%

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Lipid Peroxidation Status in Embryo Culture Media: The Impact on Fertilization and Embryo Quality during IVF Cycles

Jamil¹,

Debbarh²,

Kabit³

et al. 2022

ARRB

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Background: The process of preimplantation embryo development in vitro represents a key phase during in vitro fertilization (IVF) cycles. It involves several regulatory signaling pathways as well as an optimized in vitro culture system. The resulting embryo quality helps to determine embryo competence before implantation and pregnancy outcomes. Reactive oxygen species (ROS) are known to play a major role in influencing the process of embryo development. Their role can be reflected in the regulation of signaling pathways as second messengers or in the irreversible cell alterations due to oxidative stress following an excess of ROS levels. Methods: In this study, we investigated the association between morphological embryo quality (fertilization, cleavage quality, and fragmentation levels) and lipid peroxidation levels (Malondialdehyde) in embryo culture media. After intracytoplasmic sperm injection (ICSI), a total of 103 oocytes were evaluated on day 1 and day 3 of their development, and their corresponding culture media were analyzed by estimating MDA levels using thiobarbituric acid. Results: The results showed no significant association between MDA levels in culture media and fertilization rate (p=0.3), sperm quality (p=0.99; p= 0.17; p=0.46; p=0.30; p=0.65; p=0.44; p=0.09; p=0.15; p=0.56), embryo fragmentation levels (p=0.79; p=0.40), AMH levels (p=0.31; p=0.36) and female age (p=0.60; p=0.34). However, we revealed a significant association between cleavage quality and MDA levels in the embryo environment (p=0.03). Conclusion: We conclude that oxidative stress in IVF culture media might be mainly associated with delayed embryonic development.

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Section: Discussioncontrasting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Lipid Peroxidation Status in Embryo Culture Media: The Impact on Fertilization and Embryo Quality during IVF Cycles

Jamil¹,

Debbarh²,

Kabit³

et al. 2022

ARRB

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“…The association between pruritus and depression (5)(6)(7)(8), anxiety (7,8), insomnia (6,(9)(10)(11) and quality of life (QoL) (12,13) has been demonstrated previously in many studies. However, earlier reports have focused mostly on selected patient samples, such as those from dermatology or specified pruritus clinics (6,8) or specific patient groups (e.g. renal patients with pruritus) (14), whereas general population studies concerning the association with pruritus and psychosocial well-being are scarce (1).…”

Section: Significancementioning

confidence: 81%

“…Pruritus is a distressing symptom with extensive impact on functional, social and psychosocial behaviour (4). The association between pruritus and depression (5)(6)(7)(8), anxiety (7,8), insomnia (6,(9)(10)(11) and quality of life (QoL) (12,13) has been demonstrated previously in many studies. However, earlier reports have focused mostly on selected patient samples, such as those from dermatology or specified pruritus clinics (6,8) or specific patient groups (e.g.…”

Section: Significancementioning

confidence: 88%

“…Moreover, the severity of insomnia increased with the severity of pruritus. Many itching patients experience nocturnal pruritus, which may result in sleep disturbances (31), and a recent Korean study (n = 91) also demonstrated the association between pruritus and insomnia (6). Pruritus has multiple effects on QoL and the burden caused by pruritus is probably even higher than previously thought (4).…”

Section: Discussionmentioning

confidence: 99%

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Association between Pruritus and Psychosocial Well-being: A Population-based Study among 6,809 Subjects

et al. 2023

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Pruritus has an extensive impact on functional, social and psychosocial behaviour. The association between pruritus and psychological well-being has mostly been studied among selected patient groups, whereas population-based studies are lacking. The aim of this study was to determine the association between pruritus and insomnia, quality of life, depression and anxiety at the population level in the general population. A cross-sectional population-based study was conducted in 2012 to 2013. Study subjects (n = 6,809) belonging to the Northern Finland Birth Cohort 1966 Study participated in a large follow-up study at the age of 45–47 years. They completed an extensive health questionnaire including questions on pruritus and several previously validated questionnaires regarding symptoms of psychosocial well-being. Pruritus affected 19.9% of the study subjects weekly, being more common in women than in men (p < 0.001). A significant association was found between both localized and generalized pruritus and symptoms of insomnia, depression, anxiety and decreased quality of life. The association was seen even in those with mild psychological symptoms/insomnia, and it affected both sexes. The severity of psychological symptoms increased with increasing frequency of pruritus. In conclusion, pruritus has a multiple effect on psychosocial well-being. Physicians should consider possible psychosocial symptoms in patients with pruritus.

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Risks of Placental Abruption and Preterm Delivery in Patients Undergoing Assisted Reproduction

Zhang,

Lee,

Sauer

et al. 2024

JAMA Netw Open

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ImportancePatients using assisted reproductive technology (ART) may need additional counseling about the increased risks of placental abruption and preterm delivery. Further investigation into the potential additive risk of ART and placental abruption is needed.ObjectiveTo ascertain the risk of placental abruption in patients who conceived with ART and to evaluate if placental abruption and ART conception are associated with an increased risk of preterm delivery (&lt;37 weeks’ gestation) over and above the risks conferred by each factor alone.Design, Setting, and ParticipantsThis cross-sectional study used data from the National Inpatient Sample, which includes data from all-payer hospital inpatient discharges from 48 states across the US. Participants included women aged 15 to 54 years who delivered from 2000 through 2019. Data were analyzed from January 17 to April 18, 2024.ExposuresPregnancies conceived with ART.Main Outcomes and MeasuresRisks of placental abruption and preterm delivery in ART conception compared with spontaneous conceptions. Associations were expressed as odds ratios (ORs) and 95% CIs derived from weighted logistic regression models before and after adjusting for confounders. The relative excess risk due to interaction (RERI) of the risk of preterm delivery based on ART conception and placental abruption was also assessed.ResultsOf 78 901 058 deliveries, the mean (SD) maternal age was 27.9 (6.0) years, and 9 212 117 patients (11.7%) were Black individuals, 14 878 539 (18.9%) were Hispanic individuals, 34 899 594 (44.2%) were White individuals, and 19 910 807 (25.2%) were individuals of other races and ethnicities. Of the total hospital deliveries, 98.2% were singleton pregnancies, 68.8% were vaginal deliveries, and 52.1% were covered by private insurance. The risks of placental abruption among spontaneous and ART conceptions were 11 and 17 per 1000 hospital discharges, respectively. After adjusting for confounders, the adjusted OR (AOR) of placental abruption was 1.42 (95% CI, 1.34-1.51) in ART pregnancies compared with spontaneous conceptions, with increased odds in White women (AOR, 1.42; 95% CI, 1.31-1.53) compared with Black women (AOR, 1.16; 95% CI, 0.93-1.44). The odds of preterm delivery were significantly higher in pregnancies conceived by ART compared with spontaneous conceptions (AOR, 1.46; 95% CI, 1.42-1.51). The risk of preterm delivery increased when patients had both ART conception and placental abruption (RERI, 2.0; 95% CI, 0.5-3.5).Conclusions and RelevanceIn this cross-sectional study, patients who conceived using ART and developed placental abruption had a greater risk of preterm delivery compared with spontaneous conception without placental abruption. These findings have implications for counseling patients who seek infertility treatment and obstetrical management of ART pregnancies.

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Association between

Cited by 3 publications

References 33 publications

Lipid Peroxidation Status in Embryo Culture Media: The Impact on Fertilization and Embryo Quality during IVF Cycles

Lipid Peroxidation Status in Embryo Culture Media: The Impact on Fertilization and Embryo Quality during IVF Cycles

Association between Pruritus and Psychosocial Well-being: A Population-based Study among 6,809 Subjects

Risks of Placental Abruption and Preterm Delivery in Patients Undergoing Assisted Reproduction

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