Association Between ABO Blood Type and Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Unilateral Total Hip Arthroplasty Surgery in China

Li, Jie; Zhou, Jun; Wan, Yunqiang; Liu, Li; Ou, Cehua

doi:10.12659/msm.901736

Cited by 12 publications

(8 citation statements)

References 16 publications

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“…In addition, ABO antigens are expressed on the surfaces of a variety of cells and tissues, including red blood cells, platelets, sensory neurons, epithelial cells, and vascular endothelial cells, as well as on some plasma proteins such as vWF. Thus, ABO blood types are reportedly associated with venous thrombosis as well as various conditions such as cancer, preeclampsia, cognitive dysfunction, metabolic diseases, and infectious disorders [ 21 , 30 , 31 , 32 , 33 , 34 , 35 ]. From a different perspective, the ABO gene locus has been shown to influence angiotensin-converting enzyme activity [ 36 , 37 ]; this association suggests a potential relationship between blood type and the risk of heart failure.…”

Section: Discussionmentioning

confidence: 99%

ABO Blood Type Is Associated with Thrombotic Risk in Patients with Nonvalvular Atrial Fibrillation

Jang

Seo

Park

et al. 2022

JCM

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Blood type is reportedly correlated with the occurrence of cardiovascular diseases, presumably because of its effect on thrombogenicity. However, the relationship between blood type and thrombotic complications in atrial fibrillation (AF) remains unclear. This retrospective study analyzed the blood types of 1170 AF patients (mean age, 70 years; 58% men) who were followed up for up to 4 years. Patients with greater than mild mitral stenosis or prosthetic valves were excluded. The cohort included 305 (26%) type O, 413 (35%) type A, 333 (28%) type B, and 119 (10%) type AB patients. The primary endpoint of major adverse cerebrovascular events (MACE) occurred in 52 (4.4%) patients. When longitudinal outcomes were plotted, AB blood type patients had worse prognosis than non-AB blood type patients (p = 0.039), particularly type O blood patients (p = 0.049). Multivariate Cox regression analysis revealed that AB blood type was associated with higher MACE rates (adjusted hazard ratio, 2.01; 95% confidence interval, 1.01–4.00; p = 0.048) than non-AB blood types independent of anticoagulation therapy duration or CHA2DS2-VASc score. These indicate that AF patients with AB blood type are at an increased risk of MACE compared to those with non-AB blood type independent of the duration of anticoagulation or the CHA2DS2-VASc score.

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Section: Discussionmentioning

confidence: 99%

ABO Blood Type Is Associated with Thrombotic Risk in Patients with Nonvalvular Atrial Fibrillation

Jang

Seo

Park

et al. 2022

JCM

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“…The Numerical Rating Scale (NRS) was used to evaluate the subjective sleep quality of patients in the night prior to and following surgery (0 points for the best sleep, 10 points for the worst sleep) (21). The visual analogue scale (VAS) (29) was used to evaluate the pain intensity during rest and the movement on the first and the third postoperative days.…”

Section: Primary Outcomementioning

confidence: 99%

Dexmedetomidine improves early postoperative neurocognitive disorder in elderly male patients undergoing thoracoscopic lobectomy

Shi

et al. 2020

Exp Ther Med

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Perioperative neurocognitive disorder (PND) is a common complication following thoracic surgery that frequently occurs in patients ≥65 years. PND includes postoperative cognitive dysfunction (POCD) and postoperative delirium (POD). To investigate whether intravenous dexmedetomidine (DEX) is able to improve neurocognitive function in elderly male patients following thoracoscopic lobectomy, a randomized, double-blinded, placebo-controlled trial was performed at the Affiliated Hospital of Inner Mongolia Medical University (Hohhot, China). Patients aged ≥65 years were enrolled and were subjected to thoracic surgery under general anesthesia. A computer-generated randomization sequence was used to randomly assign patients (at a 1:1 ratio) to receive either intravenous DEX (0.5 µg/kg per h, from induction until chest closure) or placebo (intravenous normal saline). The primary endpoint was the result of the Mini-Mental State Examination (MMSE). The secondary endpoints were the results of the Montreal Cognitive Assessment (MoCA) and those obtained with the Confusion Assessment Method (CAM), as well as the incidence of POCD and POD during the first 7 postoperative days. Other observational indexes included sleep quality at night, self-anxiety scale prior to the operation and 7 days following the operation and the visual analogue scale (VAS) score at rest and during movement on the first and third day following the operation. Furthermore, at 6 h following surgery, the MMSE score in the DEX group was significantly higher than that in the saline group. At 6 h and on the first day postoperatively, the MoCA score in the DEX group was significantly higher than that in the saline group. The incidence of POCD and POD in the DEX group was 13.2 and 7.5%, respectively, while that in the saline group was 35.8 and 11.3%, respectively. There was a significant difference in the incidence of POCD between the two groups (P<0.01). In the DEX group, mean sleep quality was increased, whereas the mean VAS was decreased compared with the corresponding values in the saline group. In conclusion, elderly male patients who underwent thoracoscopic lobectomy under continuous infusion of DEX (0.5 µg/kg/h) exhibited a reduced incidence of POCD during the first 7 postoperative days as compared with the placebo group. Furthermore, DEX improved the subjective sleep quality in the first postoperative night, reduced anxiety and alleviated postoperative pain. In addition, it increased the incidence of bradycardia. The present study was registered in the Chinese Clinical Trial Registry ( www.chictr.org.cn ; registration no. ChiCTR-IPR-17010958).

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“…At present, the clinical assessment of postoperative cognitive dysfunction (POCD) is the MMSE, [14][15][16] Montreal cognitive assessment (MoCA) 17 and Wechsler Memory Scale (WMS). 16 Li et al 14 used MMSE on the relationship between ABO blood type and POCD in elderly patients undergoing unilateral total hip replacement. Han et al 15 confirmed that early POCD after tonsillectomy in children could be assessed using the MMSE.…”

Section: Discussionmentioning

confidence: 99%

Effect of propofol‐based total intravenous anaesthesia on postoperative cognitive function and sleep quality in elderly patients

et al. 2021

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Colorectal surgery is a common surgical operation in clinic, and general anaesthesia is often used during the operation. As the surgery is a traumatic operation, the body will produce a series of stress reactions, leading to postoperative gastrointestinal adverse reactions such as abdominal pain and vomiting, which are not conducive to postoperative rehabilitation. Especially in elderly patients, with the increase of age, there are more basic diseases, coupled with the deterioration of the physiological function of the organs, which reduces the rate of drug metabolism and promotes the body's sensitivity to anaesthetic drugs. Residual drugs will affect the function of the central nervous system, leading to reduced respiratory function, delayed recovery and cognitive dysfunction and other related complications. 1,2 The occurrence of cognitive dysfunction will prolong the hospital stay of elderly

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Association Between ABO Blood Type and Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Unilateral Total Hip Arthroplasty Surgery in China

Cited by 12 publications

References 16 publications

ABO Blood Type Is Associated with Thrombotic Risk in Patients with Nonvalvular Atrial Fibrillation

ABO Blood Type Is Associated with Thrombotic Risk in Patients with Nonvalvular Atrial Fibrillation

Dexmedetomidine improves early postoperative neurocognitive disorder in elderly male patients undergoing thoracoscopic lobectomy

Effect of propofol‐based total intravenous anaesthesia on postoperative cognitive function and sleep quality in elderly patients

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