Association between ABO gene polymorphism (rs505922) and cancer risk: a meta-analysis

Duan, Yunfei; Zhu, Feng; Li, Xiaodong; An, Yong; Zhang, Hanze; Zhou, Yebin; Zhang, Xiaofei; Jiang, Yong

doi:10.1007/s13277-015-3159-y

Cited by 17 publications

(12 citation statements)

References 27 publications

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“…Our genotyping analysis showed that T and C alleles of rs505922 and corresponding genotypes are distributed equally between the obese and control groups. The results of allele and genotype frequencies in our study are also comparable to the results obtained in previous studies with T allele ranging from 59 to 62% [30]. Interestingly, a recent meta-analysis provided some evidence that ABO rs505922 SNP C allele is a risk factor for cancer susceptibility, specifically for pancreatic cancer [30].…”

Section: Discussionsupporting

confidence: 90%

Thrombosis RelatedABO,F5,MTHFR,andFGGGene Polymorphisms in Morbidly Obese Patients

et al. 2016

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Objective. Obesity is a well-known risk factor for thrombotic complications. The aim of the present study was to determine the frequency of thrombosis related ABO, F5, MTHFR, and FGG gene polymorphisms in morbidly obese patients and compare them with the group of nonobese individuals. Methods. Gene polymorphisms were analyzed in 320 morbidly obese patients (BMI > 40 kg/m2) and 303 control individuals (BMI < 30 kg/m2) of European descent. ABO C>T (rs505922), F5 C>G (rs6427196), MTHFR C>T (rs1801133), and FGG C>T (rs6536024) SNPs were genotyped by RT-PCR. Results. We observed a tendency for MTHFR rs1801133 TT genotype to be linked with morbid obesity when compared to CC genotype; however, the difference did not reach the significant P value (OR 1.84, 95% CI 0.83–4.05, P = 0.129). Overall, the genotypes and alleles of rs505922, rs6427196, rs1801133, and rs6536024 SNPs had similar distribution between morbidly obese and nonobese control individuals. Distribution of height and weight means among individuals carrying different rs505922, rs6427196, rs1801133, and rs6536024 genotypes did not differ significantly. Conclusions. Gene polymorphisms ABO C>T (rs505922), F5 C>G (rs6427196), MTHFR C>T (rs1801133), and FGG C>T (rs6536024) were not associated with height, weight, or morbid obesity among European subjects.

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Section: Discussionsupporting

confidence: 90%

Thrombosis RelatedABO,F5,MTHFR,andFGGGene Polymorphisms in Morbidly Obese Patients

et al. 2016

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“…These findings have been validated in multiple populations, including American, Han Chinese, German, Japanese, Korean and Taiwanese [80–85]. Meta-analyses using both SNP rs505922 and blood types also support an association between non-O blood types and increased risk of pancreatic cancer [23,86]. Evaluation of blood groups across a spectrum of cancers revealed that the non-O blood types are associated with increased risk of exocrine pancreatic cancer but not with endocrine pancreatic cancer or any other cancer type studied, including stomach [19].…”

Section: Abo Gene Polymorphisms and Cancermentioning

confidence: 85%

The role of the histoblood ABO group in cancer

Rummel

Ellsworth²

2016

Future Sci. OA

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Since the first link between blood type and cancer was described in 1953, numerous studies have sought to determine whether the histoblood ABO group is associated with tumorigenesis. In 2009, the first significant association between a SNP located within the ABO glycosyltransferase gene and increased risk of pancreatic cancer was reported. Here, we describe the history and possible functions of the histoblood ABO group and then provide evidence for a role of blood group antigens in the most common cancer types worldwide using both blood type and SNP data. We also explore whether confusion regarding the role of blood type in cancer risk may be attributable to heterogeneity within tumor types.

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“…Particularly, the most widely investigated SNPs of the ABO gene were rs505922 and rs657152 [12][13][14][15]. Meta-analysis that evaluated the relationship between rs505922 SNP and overall cancer have already been reported by Duan et al [16] four years ago.…”

Section: Introductionmentioning

confidence: 99%

Association of ABO Polymorphisms and Pancreatic Cancer/ Cardiocerebrovascular Disease: a Meta-analysis.

Li¹,

Liu²,

Huang³

et al. 2020

Preprint

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Background: ABO gene polymorphisms have been reported to be associated with the risk of multiple cancers and cardiocerebrovascular disease s. However, the results remained controversial. In this study, we conducted a systematic review and meta-analysis to clarify the association between two SNPs (rs505922 and rs657152) in ABO gene and cancers/ cardiocerebrovascular disease s. Method: All eligible case-control studies come from PubMed, Embase and Web of Science up to Jan. 1, 2019. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the corresponding associations. Sensitivity analysis, publication bias assessment, and heterogeneity test were performed using STATA 12.0. Results : A total of nineteen articles involving twenty-two case-control populations were included according to inclusion and exclusion criteria. Twelve populations (20,820 cases and 27,837 controls) were used to evaluate the relationship between rs505922 and overall cancers and nine populations (22,275 cases and 71,549 controls) were included to assess the association between rs505922 and cardiocerebrovascular diseases. The results showed a significant association between the rs505922 polymorphism and cancers (CvsT: OR=1.13, 95%CI=1.05-1.22, P =0.001), and cardiocerebrovascular diseases (OR=1.36, 95%CI=1.19-1.57, P <0.001). Five populations (8,660 cases and 10,618 controls) were included to evaluate association between rs657152 and cancers and five populations (8,105 cases and 6,712 controls) were included to estimate the relationship between rs657152 and cardiocerebrovascular diseases. The result of meta-analysis reveals that rs657152 was significantly associated with cancers (OR=1.18, 95%CI=1.13-1.23, P <0.001) and cardiocerebrovascular diseases (OR=1.54, 95%CI=1.24-1.92, P <0.001). Conclusion: Our study suggested that ABO polymorphisms might serve as a risk factor of pancreatic cancers and cardiocerebrovascular diseases.

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Association between ABO gene polymorphism (rs505922) and cancer risk: a meta-analysis

Cited by 17 publications

References 27 publications

Thrombosis RelatedABO,F5,MTHFR,andFGGGene Polymorphisms in Morbidly Obese Patients

Thrombosis RelatedABO,F5,MTHFR,andFGGGene Polymorphisms in Morbidly Obese Patients

The role of the histoblood ABO group in cancer

Association of ABO Polymorphisms and Pancreatic Cancer/ Cardiocerebrovascular Disease: a Meta-analysis.

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