Association between ABO Genotype and Risk of Hepatocellular Carcinoma in Koreans

Shim, Hyung-Jeong; Lee, Ran; Shin, Min‐Ho; Kim, Hee-Nam; Cho, Duck; Ahn, Hye-Ran; Kweon, Sun‐Seog

doi:10.7314/apjcp.2015.16.7.2771

Cited by 15 publications

(18 citation statements)

References 28 publications

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“…ABO blood type was recently shown to affect the risk of multiple cancers 18, 19 , including HCC 16, 17 . Based on these reports, we hypothesized that the ABO blood group is associated with survival in HCC patients.…”

Section: Discussionmentioning

confidence: 99%

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ABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy

Wang

et al. 2017

Sci Rep

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ABO blood types are associated with the prognosis of several malignancies. However, the role of the ABO blood type in hepatocellular carcinoma (HCC) remains elusive. Here, we evaluated the prognostic role of the ABO blood group in 691 HCC patients after hepatectomy by Cox regression analysis. A prognostic nomogram was generated to predict the 3 and 5-year overall survival (OS). A total of 262 HCC patients (37.9%) had blood group O, 199 (28.8%) had blood group A, 165 (23.9%) had blood group B, and 65 (9.4%) had blood group AB. The median OS was 55 months in patients with blood group O, 39 months for blood group A, 34 months for blood group B, and 34 months for blood group AB patients (P = 0.001, log-rank test). There were significant differences in OS between patients with blood groups O and A [hazard ratio (HR) = 1.416; 95% CI, 1.101–1.820; P = 0.007], blood group B (HR = 1.736; 95% CI, 1.333–2.262; P < 0.001), blood group AB (HR = 1.739; 95% CI, 1.210–2.499; P = 0.003) and non-O blood groups (HR = 1.485; 95% CI, 1.204–1.830; P < 0.001). Our constructed nomogram (c-index = 0.687) predicted the prognosis more accurately than the TNM stage alone(c-index = 0.601). In conclusion, non-O blood groups are poor prognostic indicators for HCC following hepatectomy. Our findings justify further external validation in larger cohorts.

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Section: Discussionmentioning

confidence: 99%

“…A recent study reported that non-O blood groups increased the risk of HCC 16 . Another study indicated that blood group A increased the risk of developing HCC in a Korean population 17 . Although ABO blood type has been associated with the risk of HCC, its prognostic role in patients receiving hepatectomy for HCC is unclear.…”

Section: Introductionmentioning

confidence: 99%

ABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy

Wang

et al. 2017

Sci Rep

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“…In a similar case–control study of 1538 Korean patients with newly diagnosed HCC, the presence of blood group A and more specifically, the presence of the AA genotype exhibited the highest risk for HCC development compared to other blood types. [27] …”

Section: Discussionmentioning

confidence: 99%

Association between ABO blood group and HCV-related hepatocellular carcinoma risk in China

Xu²,

Ding³

et al. 2016

Medicine

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The ABO blood group has previously been reported to be associated with risk for certain malignancies; however, data about the risks for hepatocellular carcinoma (HCC) according to blood type are limited. Thus, we conducted a retrospective case–control study to investigate whether the ABO blood group contributes to hepatitis C virus (HCV) infection–induced HCC.From January 2010 to June 2016, 447 consecutive patients with chronic HCV infection were recruited. Of these patients, 217 had HCV-related HCC, and 230 had chronic hepatitis C (CHC) without HCC. We performed multivariate logistic regression to probe the association between the ABO blood group and HCC risk.Compared with subjects with blood type O, patients with blood type A had an adjusted odds ratio (AOR) of 3.301 (95% confidence interval [CI], 1.927–5.653) for HCC after adjusting for age and gender. We found statistically significant associations between blood type A and HCC risk for both men (AOR [95% CI] = 4.192 [1.959–8.973]) and women (AOR [95% CI] = 2.594 [1.231–5.466]), and for patients aged below 70 years (<60 years: AOR [95% CI] = 3.418 [1.338–8.734]; 60–69 years: AOR [95% CI] = 3.917 [1.730–8.867]).Thus, HCC risk is associated with ABO blood type in Chinese CHC patients, and CHC patients with blood type A are more susceptible to HCV-related HCC than patients with other blood types.

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“…A synergism between blood group A and HBV infection in the development of extrahepatic cholangiocarcinoma has been suggested (31). In their case-control study including 1.538 patients with newly diagnosed HCC, Shim et al (6) from Korea have concluded that blood group A and genotype AA showed the highest risk of HCC. In a study of 339.432 individuals conducted in Taiwan, A blood group was found to be associated with increased risk of stomach cancer and non-O blood types with pancreatic cancer (7).…”

Section: Discussionmentioning

confidence: 99%

“…In the early publications about this issue, cancer, peptic ulcer and thrombotic diseases were claimed to be related with ABO blood groups (2,3,4). Up to now, research on the relationship of ABO blood groups with coronary heart disease, hepatocellular carcinoma (HCC), stomach cancer, pancreatic cancer, acne vulgaris, chronic renal failure (CRF), brucellosis, malaria, Crimean-Congo haemorrhagic fever (CCHF), Helicobacter pylori (H. pylori) infection have been reported in the literature (5,6,7,8,9,10,11,12,13). Chronic hepatitis B virus (HBV) infection (CHB) is still considered as an important public health issue worldwide, despite the existing effective prophylactic vaccine and strong antiviral therapies.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the relationship between ABO/Rh blood groups and severity of liver fibrosis in patients with chronic hepatitis B

Hakyemez¹,

Durdu²,

Bölükçü³

et al. 2016

vhd

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Association between ABO Genotype and Risk of Hepatocellular Carcinoma in Koreans

Cited by 15 publications

References 28 publications

ABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy

ABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy

Association between ABO blood group and HCV-related hepatocellular carcinoma risk in China

Evaluation of the relationship between ABO/Rh blood groups and severity of liver fibrosis in patients with chronic hepatitis B

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