Association between acrolein exposure and respiratory hazards: A systematic review and meta-analysis

Liu, Qinghong; Lou, Hongwei; Zhang, Xiaofang; Qin, Yang

doi:10.1016/j.apr.2022.101633

Cited by 3 publications

(1 citation statement)

References 63 publications

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“…Its exposure leads to the induction of many diseases, including cancer. A very valuable meta-analysis of the relationship between acrolein exposure and respiratory system damage in rats/mice was made by Liu et al [ 16 ]. As the authors indicate, exposure to acrolein can significantly induce an inflammatory response in the lungs of rats/mice [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Tobacco Smoke Component, Acrolein, as a Major Culprit in Lung Diseases and Respiratory Cancers: Molecular Mechanisms of Acrolein Cytotoxic Activity

Hikisz

Jacenik

2023

Cells

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Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant that seriously threatens human health and life. Due to its high reactivity, cytotoxicity and genotoxicity, acrolein is involved in the development of several diseases, including multiple sclerosis, neurodegenerative diseases such as Alzheimer’s disease, cardiovascular and respiratory diseases, diabetes mellitus and even the development of cancer. Traditional tobacco smokers and e-cigarette users are particularly exposed to the harmful effects of acrolein. High concentrations of acrolein have been found in both mainstream and side-stream tobacco smoke. Acrolein is considered one of cigarette smoke’s most toxic and harmful components. Chronic exposure to acrolein through cigarette smoke has been linked to the development of asthma, acute lung injury, chronic obstructive pulmonary disease (COPD) and even respiratory cancers. This review addresses the current state of knowledge on the pathological molecular mechanisms of acrolein in the induction, course and development of lung diseases and cancers in smokers.

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Section: Introductionmentioning

confidence: 99%

The Tobacco Smoke Component, Acrolein, as a Major Culprit in Lung Diseases and Respiratory Cancers: Molecular Mechanisms of Acrolein Cytotoxic Activity

Hikisz

Jacenik

2023

Cells

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Investigating carbonyls (acrolein and acetaldehyde) produced from the frying process; a systematic review, meta-analysis, and health risk assessment

Atamaleki,

Naimi,

Moradpour

et al. 2024

International Journal of Environmental Analytical Chemistry

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Preliminary Assessment of Tunic Off-Gassing after Wildland Firefighting Exposure

Padamsey,

Liebenberg,

Wallace

et al. 2024

Fire

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Evidence has previously shown that outer tunics (turnout coats) worn by firefighters at structural fires are contaminated with harmful chemicals which subsequently off-gas from the material. However, there is limited research on whether this phenomenon extends to wildland firefighter uniforms. This pilot study aimed to explore if the tunics of volunteer bushfire and forestry firefighters in Western Australia off-gas any contaminants after exposure to prescribed burns or bushfires, and whether there is a need to explore this further. Nine tunics were collected from firefighters following nine bushfire and prescribed burn events, with a set of unused tunics serving as a control. Chemical analysis was performed on these tunics to assess levels of acrolein, benzene, formaldehyde, and sulphur dioxide contamination. The assessment involved measuring chemical off-gassing over a 12 h period using infrared spectrometry. Tunics worn by firefighters appear to adsorb acrolein, benzene, formaldehyde, and sulphur dioxide from bushfire smoke and these contaminants are emitted from firefighting tunics following contamination at elevated concentrations. Further investigation of this research with a larger study sample will be beneficial to understand this phenomenon better and to determine the full extent and range of chemical contaminants absorbed by all firefighter clothing.

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Association between acrolein exposure and respiratory hazards: A systematic review and meta-analysis

Cited by 3 publications

References 63 publications

The Tobacco Smoke Component, Acrolein, as a Major Culprit in Lung Diseases and Respiratory Cancers: Molecular Mechanisms of Acrolein Cytotoxic Activity

The Tobacco Smoke Component, Acrolein, as a Major Culprit in Lung Diseases and Respiratory Cancers: Molecular Mechanisms of Acrolein Cytotoxic Activity

Investigating carbonyls (acrolein and acetaldehyde) produced from the frying process; a systematic review, meta-analysis, and health risk assessment

Preliminary Assessment of Tunic Off-Gassing after Wildland Firefighting Exposure

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