Association between ADAM12 polymorphism and knee osteoarthritis in Thai population

Poonpet, Thitiya; Tammachote, Rachaneekorn; Tammachote, Nattapol; Kanitnate, Supakit; Honsawek, Sittisak

doi:10.1016/j.knee.2016.01.007

Cited by 20 publications

(33 citation statements)

References 32 publications

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“…Its expression is reported to correlate with Mankin score 62 , and increased expression has also been reported in mice 2 weeks after DMM surgery 7 . Several studies have linked ADAM12 SNPs (e.g., rs1278279, rs3740199, rs1044122, and rs1871054) with an increased risk of OA63, 64, 65, 66, 67, 68, 69, 70, although post-hoc stratification of data was often required to establish a significant association. A large case-controlled study of over 1000 UK OA patients and an equal number of matched controls failed to find any association between ADAM12 SNPs and OA 71 .…”

Section: Adamtssmentioning

confidence: 99%

ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’

Yang

Chanalaris

Troeberg

2017

Osteoarthritis and Cartilage

228

164

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SummaryIntroductionMatrix metalloproteinases (MMPs) and ‘aggrecanase’ a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play key roles in osteoarthritis (OA) through degradation of extracellular matrix (ECM) type II collagen and aggrecan, and are thus potential targets for development of OA therapies.ObjectiveThis paper aims to provide a comprehensive review of the expression and potential roles of other, lesser-known ADAMTSs and related adamalysins (or a disintegrin and metalloproteinases (ADAMs)) in cartilage, with a view to identifying potentially protective or homeostatic metalloproteinases in the joint and informing consequent selective inhibitor design.DesignA comprehensive literature search was performed using PubMed terms ‘osteoarthritis’ and ‘ADAMTS’ or ‘ADAM’.ResultsSeveral ADAMTSs and ADAMs were identified as having reportedly increased expression in OA. These include enzymes likely to play roles in cartilage matrix anabolism (e.g., the procollagen N-proteinases ADAMTS-2, ADAMTS-3 and ADAMTS-14), chondrocyte differentiation and proliferation (e.g., ADAM9, ADAM10, ADAM12), as well as enzymes contributing to cartilage catabolism (e.g., Cartilage oligomeric protein (COMP)-degrading ADAMTS-7 and ADAMTS-12).ConclusionsIn addition to the well-characterised MMPs, ADAMTS-4 and ADAMTS-5, many other ADAMTSs and ADAMs are expressed in cartilage and several show significantly altered expression in OA. Studies aimed at elucidating the pathophysiological roles of these enzymes in cartilage will contribute to our understanding of OA pathogenesis and enable design of targeted inhibitors that effectively target metalloproteinase-mediated cartilage degradation while sparing cartilage repair pathways.

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Section: Adamtssmentioning

confidence: 99%

ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’

Yang

Chanalaris

Troeberg

2017

Osteoarthritis and Cartilage

228

164

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“…Two SNPs of the ADAM12 gene, rs3740199 and rs1871054 , have been studied most frequently with OA susceptibility. It has been demonstrated that rs3740199 is associated with OA susceptibility among the general population,9 or certain groups of the studied participants 6,10. Apart from disease vulnerability, ADAM12 mutation has also been linked to OA severity 5.…”

Section: Introductionmentioning

confidence: 97%

“…Apart from that, more specific genes which conferred vulnerability of OA are still being identified. Evidence has been published for the association of OA predisposition with single-nucleotide polymorphisms (SNPs) of a member from disintegrin and metalloprotease (ADAM) family – ADAM12 4–6…”

Section: Introductionmentioning

confidence: 99%

The association of <em>ADAM12</em> polymorphism with osteoarthritis susceptibility: a meta-analysis

Zhang

2017

TCRM

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BackgroundThe pathology of osteoarthritis (OA) is partly attributed to genetic factors; however, the role of ADAM12 polymorphism is still controversial. It is necessary to perform a meta-analysis to investigate this possible correlation.MethodsCase–control studies on the association between OA susceptibility and ADAM12 polymorphism were comprehensively collected by searching PubMed, Embase, and Web of Science. Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled to evaluate OA risk that was possibly conferred by ADAM12 variant. The analyses were performed not only among general population but also in male and female groups.ResultsA total of 8 studies with 10 populations were finally included in this meta-analysis. In the general population, 4 comparisons were carried out (C allele vs G allele, CC vs GG, GC + CC vs GG, and CC vs GC + GG) and found that ADAM12 rs3740199 polymorphism was not associated with increased OA vulnerability. On the other hand, the analyses stratified by gender made 5 comparisons (C allele vs G allele, CC vs GG, GC vs GG, GC + CC vs GG, and CC vs GC + GG). It was shown that rs3740199 polymorphism (GC + CC vs GG) was a risk factor for OA among male patients (OR =1.45, 95% CI =1.04–2.01). Sensitivity analysis indicated that it was an unstable outcome. No correlation was identified in women. Neither heterogeneity nor publication bias was detected in the analyses mentioned above.ConclusionADAM12 rs3740199 polymorphism is likely to be associated with OA susceptibility among male patients, other than the general population. More studies are needed to confirm this observation. The mechanism by which ADAM12 variant plays a role in OA pathogenesis is also warranted and important for interpreting this possible correlation.

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“…On the other hand, Poonpet et al reported the rs3740199 polymorphism was associated with knee OA risk, while the effect was only found in Thai male patients [24]. The C allele of rs3740199 was found to be associated with OA in female patients in the UK [21].…”

Section: Discussionmentioning

confidence: 99%

“…Poonpet et al . [24] and Kerna et al [25] found that rs3740199 in ADAM12 was associated with knee OA risk although the results were conflicting rather than conclusion [12, 23, 26, 27]. …”

Section: Introductionmentioning

confidence: 99%

Genetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysis

Zheng¹,

Dai

et al. 2017

J Orthop Surg Res

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BackgroundKnee osteoarthritis (OA) is a complex arthritic condition in which genetic factors play an important role. ADAM12 gene is one of the recognized candidate genes although the results are conflicting. To derive a more precise estimation of the association between rs3740199 polymorphism in ADAM12 gene and risk of knee OA, we performed a meta-analysis based on six related studies, including a total of 2185 cases and 3716 controls.MethodsA comprehensive search was performed to identify related studies up to April 14, 2017. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Different genetic models were used to assess the pooled and stratified data.ResultsOverall, no significant association was found in all genetic models (C vs. G, OR = 0.983, 95% CI = 0.910–1.061; CC vs. GG, OR = 1.033, 95% CI = 0.851–1.255; CG vs. GG, OR = 1.030, 95% CI = 0.877–1.209; CC/CG vs. GG, OR = 1.031, 95% CI = 0.886–1.201; CC vs. CG/GG, OR = 1.017, 95% CI = 0.868–1.190). When stratified by ethnicity, no significant association was found.ConclusionsThis meta-analysis suggested that the rs3740199 polymorphism does not contribute to the development of knee OA. Additional well-designed large studies are required to confirm these findings in different populations.

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Association between ADAM12 polymorphism and knee osteoarthritis in Thai population

Cited by 20 publications

References 32 publications

ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’

ADAMTS and ADAM metalloproteinases in osteoarthritis – looking beyond the ‘usual suspects’

The association of <em>ADAM12</em> polymorphism with osteoarthritis susceptibility: a meta-analysis

Genetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysis

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