Association between age and serum ferritin level with bone age deficit in children with thalassemia major

Andayani, Sri Hastuti; Sekarwana, Nanan; Fadil, Ryadi

doi:10.14238/pi48.1.2008.33-6

Cited by 4 publications

(5 citation statements)

References 13 publications

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“…High serum ferritin levels and iron overload in puberty were reported to cause short stature and delayed body growths in thalassemia major patients [22]. Iron overload can prohibit bone metabolisms leading to growth disorders [23], [24]. In our present study, as thalassemia is a chronic form of anaemia, the weight difference is expected compared to control.…”

Section: Discussionmentioning

confidence: 58%

Neurocognitive Function and Its Related Potentials in Children with Beta Thalassemia Major: An Egyptian Study

El-Alameey¹,

Alzaree²,

Shehata³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Repeated blood transfusions and hemolysis in β-Thalassemia major children lead to iron overload in various organs, including the brain which may cause neurodegeneration. AIM: To evaluate intelligence quotient in children with β-thalassemia major and healthy counterparts and to assess risk factors that cause cognitive problems. SUBJECTS AND METHODS: This case-control study was performed on 50 children aged 6-16 years old with β-thalassemia major as patients group and compared with 50 healthy children as a control group of matched age, sex, and social class. Cognitive functions were evaluated by using the Wechsler Intelligence Scale for Children. Serum ferritin and iron were measured by ELISA. RESULTS: There were significantly lower mean performance and full-scale IQ scores of patients group in comparison with controls, whereas no significant differences between both groups as regards to a verbal IQ score. In thalassemic children, block design, comprehension and arithmetic were negatively correlated with age of disease onset, duration of illness and onset of chelation therapy. Serum iron and ferritin were negatively correlated with similarities and digit span. Serum iron levels were negatively correlated with performance IQ score. CONCLUSION: Children with β-thalassemia major need to receive more academic attention and cognitive assessment to improve their IQ.

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Section: Discussionmentioning

confidence: 58%

Neurocognitive Function and Its Related Potentials in Children with Beta Thalassemia Major: An Egyptian Study

El-Alameey¹,

Alzaree²,

Shehata³

et al. 2019

Open Access Maced J Med Sci

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“…[8] Other studies showed Subjects with bone age difference <36 months mostly had serum ferritin level <5,000 ng/dL, while most subjects with bone age difference >36 months had serum ferritin level =5,000 ng/dL. [9] CONCLUSION:…”

Section: Resultsmentioning

confidence: 96%

Study of vitamin D status and bone age in children with Thalassemia major

Shah

Gosai²,

Shah³

2017

IJMSCI

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Objectives: To study Vitamin D levels and bone age estimation in patients with thalassemia major and to correlate various factors associated with short stature, Vitamin D deficiency and bone age difference. Study Design: Prospective observational study Setting: Thalassemia clinic, Civil hospital, Ahmedabad Subjects and intervention: Total 84 patients with Beta-thalassemia major less than 12 years of age during 1 month period were included after taking informed consent. Study period: 15 October 2016 to 15 November 2016 Results: Out of 84 patients 34 patients had Vitamin D deficiency(<20ng/ml), 34 patients had short stature and 24 patients with bone age >36 months had age>10 years. Vitamin D levels <30ng/ml is associated with ferritin level >2500(mcg/l)(OR=2.23 p=0.02 95%CI). Age>10 year(OR=7.7 P=0.0001 95%CI) and ferritin >2500mcg/l (OR=1.9 P=0.1 95%CI)are associated with bone age difference>36 months. Increased S.ALP(OR=1.1 P=0.02 95%CI) and ferritin levels>2500 mcg/l (OR:3.6 P=0.0056 95% CI)are associated with short stature. Conclusion: Vitamin D and calcium supplementation along with disciplined transfusion and chelation regimen can likely prevent or delay late complications like short stature, osteoporosis in thalassemia patients.

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“…These results were similar with a study that showed no associations between serum ferritin and bone age. 29 Most subjects with impaired glucose tolerance had ferritin levels between 1,001 and 5,000 ng/ dL. Subjects with DM were distributed among the 1,001 -10,000 ng/dL ferritin groups.…”

Section: Discussionmentioning

confidence: 95%

Serum ferritin levels and endocrine disorders in children with thalassemia major

Dewiyanti¹,

Aditiawati

Sari³

2021

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Background Endocrine disorders in thalassemia major children patients occur due to iron overload and hemosiderosis in endocrine organs. Early detection is needed to prevent complications and improve the quality of life. An association between serum ferritin and endocrine disorders in thalassemia patients has been inconclusive to date. Objective To analyze for possible associations between serum ferritin and endocrine disorders (short stature, delayed puberty, delayed bone age, hypothyroidism, impaired glucose tolerance, and diabetes mellitus) and the incidence of each disorder in thalassemia major. Methods There were 115 thalassemia major patients aged 10-18 years involved in our cross-sectional study from June 2019 - June 2020 in the Pediatrics Department, DR. M Hosein Hospital, Palembang, South Sumatera. Anthropometry and socioeconomic status informations were collected from physical examination and interview. Ferritin, FT4, TSH, Hb and glucose levels measured by using standard methods for each item in the laboratory, mean while the skeletal age assessment was determined by using FELS method. Results This study included 83 (72.2%) girls and 32 (27.8%) boys. There were 89 (77.4%) subjects with short stature, 74 (64.4%) with delayed bone age, 30 (26.1%) with impaired glucose tolerance, 25 (21.7%) with delayed puberty, 4 (3.5%) with diabetes mellitus (DM), and none with hypothyroidism. Bivariate and multivariate analyses revealed no associations between serum ferritin and short stature, delayed bone age, impaired glucose tolerance, delayed puberty, and DM. Conclusion There is a high prevalence of endocrine disorders in pediatric thalassemia patients, especially short stature and delayed bone age. However, there are no associations between serum ferritin and endocrine disorders in these patients.

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Association between age and serum ferritin level with bone age deficit in children with thalassemia major

Cited by 4 publications

References 13 publications

Neurocognitive Function and Its Related Potentials in Children with Beta Thalassemia Major: An Egyptian Study

Neurocognitive Function and Its Related Potentials in Children with Beta Thalassemia Major: An Egyptian Study

Study of vitamin D status and bone age in children with Thalassemia major

Serum ferritin levels and endocrine disorders in children with thalassemia major

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