Association Between Age-Related Decline of Kidney Function and Plasma Malondialdehyde

Abstract

Oxidative stress is a key factor linked renal function decline with age. However, there is still no large cohort study exploring the potential role of oxidative stress in mild insufficiency of kidney function (MIKF) and chronic kidney disease (CKD) after adjusting for confounding factors. This study tested the hypothesis that oxidative stress, indicated by plasma malondialdehyde (MDA), is associated with the prevalence of MIKF and CKD after controlling the effects of confounding factors. Plasma levels of MDA and serum levels of fasting glucose, cholesterol, triglycerides, creatinine, alanine aminotransferase, and aspartate aminotransferase were analyzed from 2,169 Chinese Han adults. A questionnaire and physical examination were performed to identify and suspect risk factors of renal function decline with age. Kidney function, as indicated by estimated glomerular filtration rate, showed a significant decline with age in both male and female. Although the association between age and plasma MDA levels was nonlinear, MDA was negatively related to kidney function. The multivariate-adjusted odds ratios showed that plasma MDA had a significantly graded relation to the prevalence of MIKF and CKD with or without adjustment for covariates. By comparison with the lowest quartile, individuals with the highest quartile of MDA level had a 99% and 223% increased risk of developing MIKF and CKD, respectively. Further results from multiinteraction analysis demonstrated that plasma MDA may be the mediator linking different covariates with renal function decline. The most striking finding of this study was that oxidative stress, as indicated by plasma MDA levels, is associated with the prevalence of MIKF and/or CKD. Although imposing an increasing burden on the kidney and/or promoting a cyclical process of oxidative stress in the body, high levels of MDA in plasma may link the decline of kidney function with age.

Variations in free radical scavenging activities and antioxidant responses in salivary glands of Hyalomma anatolicum anatolicum and Hyalomma dromedarii (Acari: Ixodidae) ticks

“…MDA is generally believed to originate under stress conditions, and now it has been found to have high capability of reaction with multiple biomolecules such as proteins or DNA that leads to the formation of adducts [27]. It is further reported that excessive MDA production have also been found to be associated with different pathological states [28][29][30][31]. Hence, higher anti-inflammatory activity in SGE of H. dromedarii ticks might have helped the ticks to feed better by controlling inflammatory response mediated vasoconstriction during tick bite which is also in accordance with increased free radical scavenging activity and overall antioxidant status in these ticks.…”

Plant Food Extracts as Source of Bioactive Compounds for Prevention of Cisplatin-Induced Kidney Dysfunction in Rats

“…Oxidative stress and inflammation promote the development and progression of chronic kidney disease [Nicholas et al, 2012]. Oxidative stress is a key factor linked to renal function decline with age [Li et al, 2012]. Kidney disease progressing to end stage is an increasing burden to patients and society in general.…”

Kappa-opioid receptor agonist U50448H protects against renal ischemia-reperfusion injury in rats via activating the PI3K/Akt signaling pathway

“…Oxidative stress-related acute renal injury was reported to increase the reactive oxygen species and nitrogen species levels but to decrease the content of endogenous antioxidants [28] . As an indicator of oxidative stress, high levels of MDA in plasma exert an increasing burden on the renal system and accelerate the cycle of oxidative stress in the human body, leading to kidney function decline [29] . It is well-accepted that SOD plays an important role in the endogenous defense system against free radicals such as O 2− and H 2 O 2 [30] .…”