Association between alcohol consumption and serum dehydroepiandrosterone sulphate concentration in men with Type 2 diabetes: a link to decreased cardiovascular risk

Fukui, Michiaki; Kitagawa, Yoshihiro; Nakamura, Naoto; Kadono, Mayuko; Hasegawa, Goji; Yoshikawa, Toshikazu

doi:10.1111/j.1464-5491.2005.01629.x

Cited by 11 publications

(8 citation statements)

References 31 publications

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“…For example, unfavorable effects of alcohol consumption on chronic liver injuries were reported . On the other hand, a J‐ or U‐shaped curve relationship was also reported between alcohol consumption and type 2 diabetes mellitus or cardiovascular disease . In these reports, the number of events among participants who consume light to moderate alcohol was lower than those among participants who consume none to minimal or heavy alcohol.…”

Section: Discussionmentioning

confidence: 99%

The modest alcohol consumption reduces the incidence of fatty liver in men: a population‐based large‐scale cohort study

Hashimoto

Hamaguchi

Kojima

et al. 2015

J of Gastro and Hepatol

114

139

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Section: Discussionmentioning

confidence: 99%

The modest alcohol consumption reduces the incidence of fatty liver in men: a population‐based large‐scale cohort study

Hashimoto

Hamaguchi

Kojima

et al. 2015

J of Gastro and Hepatol

114

139

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show abstract

“…We therefore investigated relationships between alcohol consumption, serum DHEA-S concentration, and carotid atherosclerosis as evaluated by carotid ultrasonography in 404 consecutive men with type 2 diabetes [86]. Serum DHEA-S concentrations also were higher in light-to-moderate drinkers than in nondrinkers.…”

Section: Observational Studiesmentioning

confidence: 97%

Role of Endogenous Androgen Against Insulin Resistance and Athero-sclerosis in Men with Type 2 Diabetes

Fukui

Kitagawa²,

Ose³

et al. 2007

CDR

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Age-related decline in serum testosterone and dehydroepiandrosterone sulfate concentrations occur in men. Low concentrations of these endogenous androgens have been linked with insulin resistance, which is an important upstream driver for metabolic abnormalities such as hyperglycemia, hypertension, or hyperlipidemia, and increased cardiovascular risk. Moreover, men with diabetes have significantly less circulating androgen than nondiabetic men. Here, we summarize how androgen affects insulin resistance and atherosclerosis in men with type 2 diabetes. Low serum concentrations of endogenous androgens are associated with visceral fat accumulation. Androgen deprivation by castration to treat prostate cancer increases insulin resistance, while testosterone administration in type 2 diabetic men with androgen deficiency improves glucose homeostasis and decreases visceral fat, in addition to alleviating symptoms of androgen deficiency including erectile dysfunction. Androgen correlates inversely with severity of atherosclerosis and has beneficial effects upon vascular reactivity, inflammatory cytokine, adhesion molecules, insulin resistance, serum lipids, and hemostatic factors. Because men with type 2 diabetes have relative hypogonadism, testosterone supplementation could decrease both insulin resistance and atherosclerosis.

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“…[29] and Fukui et al . [30] reported that alcohol consumption during diabetes increases the total cholesterol in men.…”

Section: Discussionmentioning

confidence: 99%

“…Diabetic patients who drink alcohol have high triglyceride level. [38] Fukui et al [30] reported that long term use of alcohol can be associated with increased concentration of triglyceride which may also follow U-shaped curve. [39] In alcohol-treated diabetic rats, we observed high levels of triglycerides, this may be due to abnormalities in lipid metabolism and also excess lipolysis in the tissue and also to a number of factors such as increased availability of free fatty acids.…”

Section: Discussionmentioning

confidence: 99%

Perturbation in kidney lipid metabolic profiles in diabetic rats with reference to alcoholic oxidative stress

et al. 2009

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Diabetes is a major threat to global public health, and the number of diabetic patients is rapidly increasing worldwide. Evidence suggests that oxidative stress is involved in the pathophysiology of diabetic complications and alcoholic diseases. The aim of this study is to find out the impact of alcohol on lipid metabolic profiles in kidney tissue under streptozotocin induced diabetic condition. No study has been reported so far on the effect of alcohol on diabetic condition and also with reference to lipid metabolic profiles. Hence, the present study has been designed to elucidate the impact of alcoholism on diabetic condition. Male wistar strain albino rats were randomly divided into four groups: control (saline treated) NC, alcohol-treated (At), diabetic control (DC), and alcohol-treated diabetic rats (D+At). In alcohol-treated diabetic rats, we observed high levels of MDA, total cholesterol, triglycerides, phospholipids and also high levels of blood glucose than other groups. Moreover, degenerative changes of renal cells in alcohol-treated diabetic group were maximized by administration of alcohol as evinced by histopathological examination. This study suggests that alcohol consumption could be an aggravation factor which contributes for the formation of free radicals in diabetic condition. Therefore, consumption of alcohol during diabetic condition is harmful.

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Association between alcohol consumption and serum dehydroepiandrosterone sulphate concentration in men with Type 2 diabetes: a link to decreased cardiovascular risk

Abstract: Higher serum DHEA-S concentrations in light-to-moderate drinkers may represent part of the link between light-to-moderate alcohol consumption and lower CVD mortality.

Cited by 11 publications

References 31 publications

The modest alcohol consumption reduces the incidence of fatty liver in men: a population‐based large‐scale cohort study

The modest alcohol consumption reduces the incidence of fatty liver in men: a population‐based large‐scale cohort study

Role of Endogenous Androgen Against Insulin Resistance and Athero-sclerosis in Men with Type 2 Diabetes

Perturbation in kidney lipid metabolic profiles in diabetic rats with reference to alcoholic oxidative stress

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