Perturbation in kidney lipid metabolic profiles in diabetic rats with reference to alcoholic oxidative stress

Abstract

Diabetes is a major threat to global public health, and the number of diabetic patients is rapidly increasing worldwide. Evidence suggests that oxidative stress is involved in the pathophysiology of diabetic complications and alcoholic diseases. The aim of this study is to find out the impact of alcohol on lipid metabolic profiles in kidney tissue under streptozotocin induced diabetic condition. No study has been reported so far on the effect of alcohol on diabetic condition and also with reference to lipid metabolic profiles. Hence, the present study has been designed to elucidate the impact of alcoholism on diabetic condition. Male wistar strain albino rats were randomly divided into four groups: control (saline treated) NC, alcohol-treated (At), diabetic control (DC), and alcohol-treated diabetic rats (D+At). In alcohol-treated diabetic rats, we observed high levels of MDA, total cholesterol, triglycerides, phospholipids and also high levels of blood glucose than other groups. Moreover, degenerative changes of renal cells in alcohol-treated diabetic group were maximized by administration of alcohol as evinced by histopathological examination. This study suggests that alcohol consumption could be an aggravation factor which contributes for the formation of free radicals in diabetic condition. Therefore, consumption of alcohol during diabetic condition is harmful.

Structural Changes Induced by Potassium Dichromate in Renal Cortex of Adult Male Albino Rats and the Possible Protective Role of Selenium

“…De-Vries et al, [19] stated that in vivo and in vitro experiments, there was an association between intrarenal accumulation of lipid components and renal injury. In addition, Shanmugam et al, [20] reported fatty infiltration in renal tissue of diabetic rat and attributed this to oxidative stress that led to free radicals formation and abnormal fat metabolism.…”

Vindoline—A Natural Product from Catharanthus Roseus Reduces Hyperlipidemia and Renal Pathophysiology in Experimental Type 2 Diabetes

“…Histopathological examination of the kidney tissue in diabetic control group showed severe loss of the glomerular capillaries, tubular cell degeneration and presence of hyaline casts (Figure 5). These changes observed may be attributed to glomerular hyper filtration, disturbed glucose metabolism and oxidative tissue damage [50,51]. The diabetic group treated with vindoline showed gradual improvement in the structure of the glomerulus and the renal tubules although the renal tubules still had hyaline casts within their lumen.…”

In Vivo Interrelationship between Insulin Resistance and Interferon Gamma Production: Protective and Therapeutic Effect of Berberine

“…In the present study, hepatic TBARS level was increased in the HFD group. It is reported that hyperglycemia and hypertriglyceridemia evoke the hepatic lipid peroxidation due to β -oxidation overload that is characterized by high TBARS level [ 42 ]. Also level of GSH, GST, and NO are elevated in HFD group.…”