Association between ambient particulate matter exposure and semen quality in Wuhan, China

Wu, Li; Jin, Lei; Shi, Tingming; Zhang, Bing; Zhou, Yun; Zhou, Ting; Bao, Wei; Xiang, Hua; Zuo, Yao; Li, Guanlian; Wang, Cheng; Duan, Yong‐Gang; Peng, Zhe; Huang, Xiji; Hai, Zhang; Xu, Tian; Li, Yonggang; Pan, Xinyun; Xia, Ying; Gong, Xun; Chen, Weihong; Liu, Yuewei

doi:10.1016/j.envint.2016.11.013

Cited by 87 publications

(61 citation statements)

References 24 publications

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“…The present study did not find evidence for the adverse impact of air pollution on sperm density in the male patients first reporting for fertility treatment. This is consistent with the report by Santi et al [36] who found no association between PM 10 and sperm count per 1 ml of ejaculate, as opposed to Wu et al [37] who claimed that exposure to PM 10 did reduce sperm density. Published reports on the impact of air pollution on semen quality are increasingly numerous, but the findings vary greatly.…”

Section: Discussionsupporting

confidence: 92%

“…Radwan et al [38] stated that PM 2.5 , PM 10 , CO, and NO x had a detrimental impact on sperm morphology, whereas Michniewicz et al [39] found no correlation between exposure to NO 2 or SO 2 and a normal sperm percentage, which is consistent with the present findings. Wu et al [36] demonstrated that exposure to NO 2 and PM 10 in the air reduced sperm motility, while Santi et al [37] found no correlation between PM 10 exposure and the percentage of progressive sperm, which is in line with the present findings. Lower sperm motility resulting from exposure to air pollutants was also described by De Rosa et al [40], Guven et al [41], Boggia et al [42], and Calogero et al [43], though the authors did not analyze the impact of specific chemicals present in the air.…”

Section: Discussionsupporting

confidence: 91%

“…In the present study, no statistically significant associations were found between age and sperm density or to O 3 in the air contributes to lower percentages of sperm with normal morphology. The adverse impact of air pollution on semen quality was confirmed by Wu et al, who reported a deterioration in sperm morphology with exposure to PM 10 and SO 2 [36]. In turn, Santi et al only demonstrated an impact of PM 10 on sperm morphology [37].…”

Section: Discussionmentioning

confidence: 95%

See 2 more Smart Citations

Air pollution and semen parameters in men seeking fertility treatment for the first time

Wdowiak¹,

Wdowiak²,

Bień³

et al. 2019

Int J Occup Med Environ Health

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The purpose of this paper was to analyze the relationship between the selected chemical air pollutants found in the Lublin Province and the semen parameters of men seeking fertility treatment for the first time. Material and Methods: The study involved an analysis of semen sample test results obtained from male patients first reporting for fertility treatment in reproductive health centers in the Lublin Province, Poland. The data set comprises semen parameters of 13 148 men, and the number of samples in the reference period was 255-769 annually. Data on air pollution were obtained from the website of the Polish General Environmental Inspectorate and included selected chemical air pollutant levels, i.e., NO 2 , SO 2 , O 3 , and PM 10. Results: The mean PM 10 levels in the air increased, on average, by 0.65 μg/m 3 annually in 2000-2015 (p = 0.029); the mean levels of O 3 , NO 2 , SO 2 did not change significantly in the analyzed period. There were increasing trends in the mean sperm density and total sperm count of the subjects in 1992-2015 (p < 0.001). The mean percentage of sperm with normal morphology significantly decreased in the subsequent analysis peri

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Air pollution and semen parameters in men seeking fertility treatment for the first time

Wdowiak¹,

Wdowiak²,

Bień³

et al. 2019

Int J Occup Med Environ Health

View full text Add to dashboard Cite

show abstract

“…21,24 We assessed exposures for the four time windows, because the development of human sperm takes approximately 90 days and includes three key periods, including epididymal storage, development of sperm motility, and spermatogenesis corresponding to 0-9, 10-14, and 70-90 days before semen ejaculation. 6,11 Specifically, locations for both subjects’ residence and monitoring stations were geocoded to obtain the longitude and latitude coordinates.…”

Section: Methodsmentioning

confidence: 99%

Inverse Association between Ambient Sulfur Dioxide Exposure and Semen Quality in Wuhan, China

Liu

Zhou²,

Ma³

et al. 2017

Environ. Sci. Technol.

Self Cite

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Evidence concerning the association between ambient gaseous air pollutant exposures and semen quality is sparse, and findings in previous studies remain largely inconsistent. We enrolled 1759 men with 2184 semen examinations at a large reproductive medical center in Wuhan, China between 2013 and 2015. Inverse distance weighting interpolation was performed to estimate individual exposures to SO2, NO2, CO and O3 during the entire period (lag 0–90 days) and key periods (lag 0-9, 10-14, 70-90 days) of sperm development. Linear mixed models were used to analyze exposure-response relationships. SO2 exposure with 0-90 days lag was significantly associated with monotonically decreased sperm concentration (β for each interquartile range increase of exposure: −0.14; 95% CI: −0.23, −0.05), sperm count (−0.21; −0.30, −0.12) and total motile sperm count (−0.16; −0.25, −0.08). Significant associations were observed for total and progressive motility only when SO2 exposure was at the highest quintile (all Ptrend < 0.05). Similar trends were observed for SO2 exposure with 70-90 days lag. NO2, CO, or O3 exposure was not significantly associated with semen quality. Our results suggest that ambient SO2 exposure adversely affects semen quality, and highlight the potential to improve semen quality by reducing ambient SO2 exposure during early stage of sperm development.

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“…Although targeting HSP70 function likely impacts a large array of cellular functions that are altered to sustain malignancy, including inhibition of cell proliferation by inducing cellular senescence and decreased tumor cell survival by promoting apoptosis (30,31), the specific mechanisms by which HSP70 loss may affect growth of specific tumor types, including HCC, are not well understood. Moreover, the potential therapeutic utility of inhibiting HSP70 on DNA damage repair pathways to affect genomic stability and thus influencing the barrier for tumor initiation and progression is elusive (32,33). This prompted us to investigate a possible causal relationship between protein homeostasis accomplished by the HSP70 molecular chaperone machinery and regulation of the carcinogen-induced DNA damage response (DDR) and growth factor signaling resulting in HCC initiation and progression.…”

mentioning

confidence: 99%

The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways

et al. 2019

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Delineating the mechanisms that drive hepatic injury and hepatocellular carcinoma (HCC) progression is critical for development of novel treatments for recurrent and advanced HCC but also for the development of diagnostic and preventive strategies. Heat shock protein 70 (HSP70) acts in concert with several cochaperones and nucleotide exchange factors and plays an essential role in protein quality control that increases survival by protecting cells against environmental stressors. Specifically, the HSP70-mediated response has been implicated in the pathogenesis of cancer, but the specific mechanisms by which HSP70 may support malignant cell transformation remains to be fully elucidated. Here, we show that genetic ablation of HSP70 markedly impairs HCC initiation and progression by distinct but overlapping pathways. This includes the potentiation of the carcinogen-induced DNA damage response, at the tumor initiation stage, to increase the p53-dependent surveillance response leading to the cell cycle exit or death of genomically damaged differentiated pericentral hepatocytes, and this may also prevent their conversion into more proliferating HCC progenitor cells. Subsequently, activation of a mitogenactivated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) negative feedback pathway diminishes oncogenic signals, thereby attenuating premalignant cell transformation and tumor progression. Modulation of HSP70 function may be a strategy for interfering with oncogenic signals driving liver cell transformation and tumor progression, thus providing an opportunity for human cancer control.

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Association between ambient particulate matter exposure and semen quality in Wuhan, China

Cited by 87 publications

References 24 publications

Air pollution and semen parameters in men seeking fertility treatment for the first time

Air pollution and semen parameters in men seeking fertility treatment for the first time

Inverse Association between Ambient Sulfur Dioxide Exposure and Semen Quality in Wuhan, China

The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways

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