Association between anemia and sarcopenia among Chinese elderly: A cross-sectional study based on the China health and retirement longitudinal study

Dai, Senjie; Wang, Shihui; He, Yujing; Dai, Chenglong; Yu, Jiahui; Ma, Xin

doi:10.1016/j.exger.2023.112183

Cited by 8 publications

(4 citation statements)

References 48 publications

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“…For men, gender was set to 1; for women, it was set to 2. This equation accounts for ASM in adult individuals from China [ 17 ] and has been verified in previous studies [ 13 , 18 , 19 ].…”

Section: Methodssupporting

confidence: 54%

Association between relative muscle strength and cardiovascular disease among middle-aged and older adults in China

Ji,

Zhao,

Xiao

et al. 2024

BMC Public Health

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Background The association between sarcopenia and cardiovascular disease (CVD) is well known. However, the clinical diagnosis of sarcopenia is complex and not suitable for early clinical identification and prevention of CVD. Relative muscle strength (RMS) is a relatively quantitative and straightforward indicator, but its association with CVD remains unclear. Hence, the objective of this research was to investigate the correlation between RMS and CVD incidence. Methods This was a cross-sectional study, using data from the China Health and Retirement Longitudinal Study (CHARLS) in 2011. CVD events were assessed through self-reported physician diagnoses. The RMS was determined by dividing the maximum grip strength by the appendicular skeletal muscle mass (ASM). This study used multivariate logistic regression and restricted cubic spline (RCS) curves to explore the correlation between RMS and CVD incidence. Additionally, we conducted subgroup analyses to provide additional evidence supporting the association between the two variables. Results A total of 8,733 people were included in our study, with 1,152 (13.19%) CVD patients and 7,581 (86.81%) non-CVD patients. When the data were grouped according to quartiles (Q) of RMS, the inverse association between CVD and RMS remained statistically significant even after controlling for all potential confounding factors. Compared with participants in Q1 of RMS, the ORs (95% CIs) of CVD among those in Q2-Q4 were 0.99 (0.83, 1.17), 0.81 (0.67, 0.98), and 0.70 (0.57, 0.85), respectively. Moreover, the RCS results showed a negative linear correlation between the RMS and CVD incidence (P for nonlinearity = 0.555). Subgroup analysis revealed no significant interaction in any of the groups except for the sex group (P for interaction = 0.046). Conclusion Our study indicated a stable negative correlation between RMS and CVD incidence. RMS is helpful for the early identification and prevention of CVD.

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“…For men, gender was set to 1; for women, it was set to 2. This equation accounts for ASM in adult individuals from China [ 17 ] and has been verified in previous studies [ 13 , 18 , 19 ].…”

Section: Methodssupporting

confidence: 54%

Association between relative muscle strength and cardiovascular disease among middle-aged and older adults in China

Ji,

Zhao,

Xiao

et al. 2024

BMC Public Health

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“…Grade II complications, encompassing anemia, hypoproteinemia, dyspnea, skin allergy, hypertension, hyperglycemia, liver damage, pulmonary infection, seizures, gout attacks, and urinary retention, were identified in this study. Anemia independently heightens the risk of sarcopenia in the elderly Chinese population [ 38 ]. This correlation partly stems from the fatigue-prone nature, abnormal Iron metabolism and malnutrition of anemic individuals, which can result in reduced physical activity and subsequent muscle function decline [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…Anemia independently heightens the risk of sarcopenia in the elderly Chinese population [ 38 ]. This correlation partly stems from the fatigue-prone nature, abnormal Iron metabolism and malnutrition of anemic individuals, which can result in reduced physical activity and subsequent muscle function decline [ 39 ]. The increased prevalence of postoperative anemia in patients with sarcopenia aligns with previous research finding [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of sarcopenia in elderly patients undergoing elective total hip arthroplasty on postoperative outcomes: a propensity score-matched study

Su,

Peng,

Dong

et al. 2024

BMC Anesthesiol

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Objective Frailty poses a crucial risk for postoperative complications in the elderly, with sarcopenia being a key component. The impact of sarcopenia on postoperative outcomes after total hip arthroplasty (THA) is still unclear. This study investigated the potential link between sarcopenia and postoperative outcomes among elderly THA patients. Methods Totally 198 older patients were enrolled in this study. Sarcopenia in this group was determined by assessing the skeletal muscle index, which was measured using computed tomography at the 12th thoracic vertebra and analyzed semi-automatically with MATLAB R2020a. Propensity score matching (PSM) was employed to evaluate postoperative complications of grade II and above (POCIIs). Results The variables balanced using PSM contained age, sex and comorbidities including hypertension, diabetes, hyperlipidemia and COPD. Before PSM, sarcopenic patients with reduced BMI (24.02 ± 0.24 vs. 27.11 ± 0.66, P < 0.001) showed higher POCIIs rates (48.31% vs. 15%, P = 0.009) and more walking-assisted discharge instances (85.96% vs. 60%, P = 0.017) compared with non-sarcopenia patients. After PSM, this group maintained reduced BMI (23.47 ± 0.85 vs. 27.11 ± 0.66, P = 0.002), with increased POCIIs rates (54.41% vs. 15%, P = 0.002) and heightened reliance on walking assistance at discharge (86.96% vs. 60%, P = 0.008). Conclusion Sarcopenia patients exhibited a higher incidence of POCIIs and poorer physical function at discharge. Sarcopenia could serve as a valuable prognostic indicator for elderly patients undergoing elective THA.

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“…The maximum value was recorded after testing both hands twice, using a dynamometer at a right angle. A previously reported mathematical formula was used to estimate ASM in the Chinese population [ 24 – 27 ]: ASM = 0.193 × weight (kg) + 0.107 × height (cm) – 4.157 × sex – 0.037 × age (year) – 2.631. Sex was set to one if male; otherwise, it was set to two.…”

Section: Methodsmentioning

confidence: 99%

Association between relative muscle strength and hypertension in middle-aged and older Chinese adults

Luo,

Zhang,

Yang

et al. 2023

BMC Public Health

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Background The association between muscle defects and hypertension is well-established. However, the absence of pertinent and uncomplicated clinical indicators presents a challenge. Relative muscle strength (RMS) may offer a viable indicator. This study aimed to explore the association between RMS and hypertension. Methods A total of 12,720 individuals aged ≥ 45 years from the 2011 wave of the China Health and Retirement Longitudinal Study (CHARLS) were included. Grip strength was recorded and appendicular skeletal muscle mass (ASM) was estimated using a validated mathematical formula. The RMS was calculated as the ratio of grip strength to ASM. Hypertension was determined based on previous diagnosis, history of hypertension medication use, and current blood pressure. Logistic regression models were employed to investigate the relationship between RMS and hypertension. Results The prevalence of hypertension was 41.7% (5,307/12,720 patients). RMS was negatively correlated with hypertension with an OR (95% CI) of 0.68 (0.59–0.79) for males, 0.81 (0.73–0.90) for females, and 0.78 (0.72–0.85) for the entire population after adjusting for related covariates including age, education, marital history, smoking history, drinking history, diabetes, hyperlipidemia, and obesity. The trend test showed a linear association among males, females, or the entire population. Stratified analysis showed a consistent negative correlation between RMS and hypertension. Conclusions Higher RMS is an independent protective factor against hypertension and efforts to promote RMS may be beneficial for the prevention and management of hypertension.

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Association between anemia and sarcopenia among Chinese elderly: A cross-sectional study based on the China health and retirement longitudinal study

Cited by 8 publications

References 48 publications

Association between relative muscle strength and cardiovascular disease among middle-aged and older adults in China

Association between relative muscle strength and cardiovascular disease among middle-aged and older adults in China

Impact of sarcopenia in elderly patients undergoing elective total hip arthroplasty on postoperative outcomes: a propensity score-matched study

Association between relative muscle strength and hypertension in middle-aged and older Chinese adults

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