Association between angiotensin-converting enzyme gene polymorphism and diabetic retinopathy in the Chinese population

Abstract

Objective: The angiotensin-converting enzyme (ACE) gene has been implicated in the development of diabetic retinopathy (DR). However, the results have been conflicting. In this study, we performed a meta-analysis to assess the association of insertion/deletion (I/D) polymorphism in the ACE gene with DR in the Chinese population. Methods: Published literature from PubMed, CNKI, CBM and Wanfang Data were retrieved. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed-or random-effects model.

Association between the Angiotensin-Converting Enzyme (ACE) Genetic Polymorphism and Diabetic Retinopathy—A Meta-Analysis Comprising 10,168 Subjects

“…It is worth emphasizing that our current meta-analysis obtained several critically different conclusions from the previous reports [56,57]. In Zhou’s [56] report, they conducted a separate analysis of only the T2DM and T1DM groups, which showed that the ACE genotype has a non-significant association with DR, regardless of diabetic type.…”

“…Numerous investigations into the potential role of ACE as a susceptibility gene for DR have been conducted over the past decades, with controversial results. Early meta-analyses attempted to reconcile these findings, but attempts to draw definite conclusions have been hindered by limited data, particularly when examining specific patient subgroups and increased relative studies [56,57]. …”

“…Although several meta-analyses have been published [56,57], they still did not reach a consistent conclusion. To better shed light on these conflicting findings and to quantify the potential between-study heterogeneity and provide better ability to detect smaller effect sizes, we conducted a comprehensive meta-analysis on 40 published studies from 1994 to 2016 with 4252 diabetic retinopathy cases and 5916 controls relating the variant of the ACE I/D polymorphism to the risk of developing DR.…”

Angiotensin-converting enzyme I/D polymorphism and diabetic peripheral neuropathy in type 2 diabetes mellitus: A meta-analysis

“…9 In addition, Lu and colleagues showed that I/D polymorphism in the ACE gene was associated with diabetic retinopathy. 10 However, whether ACE I/D polymorphism is associated with DPN is still unclear. Li found that the ACE D allele was significantly linked with essential hypertension susceptibility.…”

Angiotensin‐converting enzyme gene variants interact with the renin–angiotensin system pathway to confer risk and protection against type 2 diabetic retinopathy

“…comprising 2,224 Chinese patients showed moderate evidence of a relationship between the ACE insertion/deletion (I/D) polymorphism and proliferative diabetic retinopathy (PDR) 1 ; however, the role of other renin-angiotensin system (RAS) polymorphisms and their possible interactions with ACE I/D genotypes are less Multivariate logistic regression was used to compute the odds ratio for developing diabetic retinopathy by adjusting for potential confounders, which include age, sex, glycated hemoglobin, duration of diabetes, smoking, systolic blood pressure and triglyceride levels, angiotensin converting enzyme inhibitor/angiotensin II type 1 receptor blocker, serum creatinine and estimated glomerular filtration rate. Genomic DNA was isolated from peripheral blood using the proteinase K chloroform-phenol method.…”