Association between ANGPTL3, 4, and 8 and lipid and glucose metabolism markers in patients with diabetes

Harada, Marina; Yamakawa, Tadashi; Kashiwagi, Rie; Ohira, Akeo; Sugiyama, Mai; Sugiura, Yasuyuki; Kondo, Yoshinobu; Terauchi, Yasuo

doi:10.1371/journal.pone.0255147

Cited by 14 publications

(20 citation statements)

References 44 publications

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“…When showing that triglycerides (TG) have played a role in mediating this strong relationship. Although ANGPTL8 has been linked to glucose and cholesterol metabolism [26], [28], in our findings revealed that there was nonsignificant association between HDL-C and ANGPTL8. Previous studies have looked into the correlates among ANGPTL8, insulin resistance, and glucose metabolism [10], [34], [35].…”

Section: The Correlation Between Biochemical Markers and Demographic ...contrasting

confidence: 73%

“…Our results showed a positive relationship between triglycerides and cholesterol and a negative relationship with ANGPTL8 [26], [27]. In animals lacking ANGPTL8 exhibited significantly lower TG [28]. Our research, show in the table.2, The present results showed that (poor HBA1c) for T2DM, high levels of TG, and ANGPTL8 were all significantly associated with risk of obesity in female patients.…”

Section: Comparison Of a Clinical Between T2dm Patients And Controlssupporting

confidence: 62%

“…A distinguishing indicator of obesity is elevated TG levels, as evidenced by both clinical trials [46]. It is well established that ANGPTL8 mainly contributes to the regulation of triglyceride metabolism [26], [28]. It has been shown that exposure of ANGPTL8 KO mice leads to low levels of TG in the blood and significantly increases their secretion of TG levels.…”

Section: The Correlation Between Biochemical Markers and Demographic ...mentioning

confidence: 99%

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The predictive diagnosis for ANGPTL8 level in women with T2DM

Fadhel

Al-Khakani

2022

ijhs

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Background: The metabolic syndrome including type 2 diabetes mellitus(T2DM), insulin resistance(IR), obese, hypertension, and dyslipidemia, is an increasing health burden. In the last decade, various metabolic hormones have been noticed to significantly role obese and associated complications. for example of this, the adipokines or hepatokines secreted proteins from hepatocyte and adipocyteare correlate with metabolic syndrome. Angiopoietin-like protein 8 (ANGPTL8) has a novel hepatokine or adipokine, which is mostly expressed in the adipose tissue, and liver stimulates the β-cell proliferation as a pancreatic in an insulin resistance state. It's a recently discovered the endocrine regulator associated with glucose homeostasis, IR, and metabolism of lipid. Materials and Methods: Ninety women participated in this study, comprising sixty patients with diabetes mellitus type-2 and thirty healthy (sex and age - matched) as a control group. Enzyme linked immune sorbent assay (ELISA) was used to assess ANGPTL8 and insulin. Standard procedures were used to measure fasting blood glucose, lipid profile, and glycated hemoglobin (HBA1c) in a certified laboratory. Results: Diabetes patients had higher levels of ANGPTL8 than the control group. The blood ANGPTL8 level in the Type-2 diabetes group varied from 4432.89±1171.09 pg/ml, while the control group's level was 2892.11±537.91pg/dl (p<0.0001).

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Section: The Correlation Between Biochemical Markers and Demographic ...contrasting

confidence: 73%

Section: Comparison Of a Clinical Between T2dm Patients And Controlssupporting

confidence: 62%

Section: The Correlation Between Biochemical Markers and Demographic ...mentioning

confidence: 99%

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The predictive diagnosis for ANGPTL8 level in women with T2DM

Fadhel

Al-Khakani

2022

ijhs

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“…Previous studies have found a link between ANGPTL3 and HDL-C levels (15,17,37). Mechanistically, ANGPTL3 reduces plasma HDL-C levels by inhibiting phospholipase EL, which hydrolyzes HDL-PL (16).…”

Section: Discussionmentioning

confidence: 96%

ANGPTL3 Is Involved in the Post-prandial Response in Triglyceride-Rich Lipoproteins and HDL Components in Patients With Coronary Artery Disease

Guo

Huang

Chen

et al. 2022

Front. Cardiovasc. Med.

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It is well-established that there exists an inverse relationship between high-density lipoprotein (HDL) cholesterol and triglyceride (TG) levels in the plasma. However, information is lacking on the impact of post-prandial triglyceride-rich lipoproteins (TRLs) on the structure of HDL subclasses in patients with coronary artery disease (CAD). In this study, the data of 49 patients with CAD were analyzed to evaluate dynamic alterations in post-prandial lipid profiles using nuclear magnetic resonance-based methods. An enzyme-linked immunosorbent assay was used to quantify the serum angiopoietin-like protein 3 (ANGPTL3). After glucose supplementation, the expression of hepatic ANGPTL3 was evaluated both in vitro and in vivo. Compared to fasting levels, the post-prandial serum TG level of all participants was considerably increased. Although post-prandial total cholesterol in HDL (HDL-C) remained unchanged, free cholesterol in HDL particles (HDL-FC) was significantly reduced after a meal. Furthermore, the post-prandial decrease in the HDL-FC level corresponded to the increase in remnant cholesterol (RC), indicating the possible exchange of free cholesterol between HDL and TRLs after a meal. Moreover, CAD patients with exaggerated TG response to diet, defined as TG increase >30%, tend to have a greater post-prandial increase of RC and decrease of HDL-FC compared to those with TG increase ≤30%. Mechanistically, the fasting and post-prandial serum ANGPTL3 levels were significantly lower in those with TG increase ≤30% than those with TG increase >30%, suggesting that ANGPTL3, the key lipolysis regulator, may be responsible for the different post-prandial responses of TG, RC, and HDL-FC.

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“…Recent studies in apparently healthy subjects [61] and patients with diabetes [62] have reported a positive association between increased plasma ANGPTL3 and sdLDL particles. These findings suggest possible beneficial effects of ANGPTL3 inhibition on sdLDL, which should be verified in the future.…”

Section: Evinacumabmentioning

confidence: 98%

Novel Pharmaceutical and Nutraceutical-Based Approaches for Cardiovascular Diseases Prevention Targeting Atherogenic Small Dense LDL

et al. 2022

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Compelling evidence supports the causative link between increased levels of low-density lipoprotein cholesterol (LDL-C) and atherosclerotic cardiovascular disease (CVD) development. For that reason, the principal aim of primary and secondary cardiovascular prevention is to reach and sustain recommended LDL-C goals. Although there is a considerable body of evidence that shows that lowering LDL-C levels is directly associated with CVD risk reduction, recent data shows that the majority of patients across Europe cannot achieve their LDL-C targets. In attempting to address this matter, a new overarching concept of a lipid-lowering approach, comprising of even more intensive, much earlier and longer intervention to reduce LDL-C level, was recently proposed for high-risk patients. Another important concern is the residual risk for recurrent cardiovascular events despite optimal LDL-C reduction, suggesting that novel lipid biomarkers should also be considered as potential therapeutic targets. Among them, small dense LDL particles (sdLDL) seem to have the most significant potential for therapeutic modulation. This paper discusses the potential of traditional and emerging lipid-lowering approaches for cardiovascular prevention by targeting sdLDL particles.

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Association between ANGPTL3, 4, and 8 and lipid and glucose metabolism markers in patients with diabetes

Cited by 14 publications

References 44 publications

The predictive diagnosis for ANGPTL8 level in women with T2DM

The predictive diagnosis for ANGPTL8 level in women with T2DM

ANGPTL3 Is Involved in the Post-prandial Response in Triglyceride-Rich Lipoproteins and HDL Components in Patients With Coronary Artery Disease

Novel Pharmaceutical and Nutraceutical-Based Approaches for Cardiovascular Diseases Prevention Targeting Atherogenic Small Dense LDL

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