Association Between Anxiety and Depression and Gastroesophageal Reflux Disease: Results From a Large Cross-sectional Study

Choi, Ji Min; Yang, Jong In; Kang, Seung Joo; Han, Yoo Min; Lee, Jooyoung; Lee, Changhyun; Chung, Su Jin; Yoon, Duk Yong; Park, Boram; Kim, Yong Sung

doi:10.5056/jnm18069

Cited by 89 publications

(80 citation statements)

References 43 publications

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“…This supports the concept that GERD symptoms are greatly influenced by psychological factors [7]. To the best of our knowledge, few published global reports establish a relationship between psychological factors, including depression and anxiety, and GERD symptoms to date and the outcomes of those studies are not consistent [8].…”

Section: Introductionsupporting

confidence: 69%

Depression and Anxiety in Patients with Gastroesophageal Reflux Disorder With and Without Chest Pain

Mohammad¹,

Chandio²,

Soomro³

et al. 2019

Cureus

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Introduction Gastroesophageal reflux disease (GERD) influences patients' general health, daily and social functioning, and physical and emotional activities. It strongly affects the health-related quality of life with frequent interruptions during sleep, work, and social activities. GERD is defined as a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications. GERD symptoms are a major concern for many patients, as they cause a disturbance in physical, social and emotional health. In this study, we determine the prevalence of anxiety and depression in patients with GERD with and without chest pain. Methods In this cross-sectional study, a total of 258 consecutive patients with a diagnosis of GERD were included in this study. Of 258 participants, 112 had concerns about chest pain. Clinical presentations and comorbid disorders were evaluated by a previously validated gastroesophageal reflux symptom questionnaire. Depressive and anxious symptoms were assessed using a Hospital Anxiety/Depression Scale. Results A total of 107 (41.4%) participants had depression, 89 (34.4%) participants had anxiety, and 70 (27.13%) had both depression and anxiety. Depression and anxiety were significantly higher in patients with GERD and chest pain. Conclusion Anxiety and depression were significantly higher in patients with GERD, particularly those who also reported concerns of chest pain. Measures should be taken to reduce the stress and anxiety of GERD patients to cope with their daily life activities and improve their quality of life.

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Section: Introductionsupporting

confidence: 69%

Depression and Anxiety in Patients with Gastroesophageal Reflux Disorder With and Without Chest Pain

Mohammad¹,

Chandio²,

Soomro³

et al. 2019

Cureus

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“…[8] In Asia, the prevalence of RE in general community were reported to be 6.8% in Japan [21] and 8% in Korea. [22] In China, a mere handful of population-based endoscopy studies were conducted in Chinese general community residents and reported the RE prevalence to vary in 1.99% to 6.40%, [7,12] and it showed a slightly increasing trend. But the data about RE prevalence condition in the ESCC popular area has not been reported yet.…”

Section: Discussionmentioning

confidence: 99%

A population-based survey of gastroesophageal reflux disease in a region with high prevalence of esophageal cancer in China

Wang

Zhang

et al. 2019

Chinese Medical Journal

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Background: The exact relationship between gastroesophageal reflux disease (GERD) and esophageal squamous cell cancer (ESCC) is far from clarification. The aim of this study was to investigate the epidemiology of GERD in a region with high prevalence of ESCC in China. Methods: A population-based, cross-sectional study was conducted in a high ESCC prevalent area, Anyang, Henan, China. All subjects fulfilled questionnaires and underwent gastroendoscopy with routine esophageal biopsy. The subjects were divided into GERD subtypes (reflux esophagitis [RE] and non-erosive reflux disease [NERD]) and controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to examine risk factors for RE and NERD. Results: A total of 2844 subjects were finally enrolled. The prevalence of GERD (RE + NERD) was 17.3%. Among them, 271 (9.53%) adults were diagnosed with RE. The prevalence of RE increased with age (7.09% in 45–50 years, 8.00% in 51–60 years, and 9.53% in 61–69 years, χ 2 = 62.216, P < 0.001). Sixty-seven (2.36%) subjects were diagnosed with the silent RE. A total of 221 (7.77%) subjects were diagnosed with NERD. Frequent liquid food consumption (OR [95% CI]: 1.502 [1.076–2.095]) was independent risk factor for RE as well as age, male gender, high body mass index (BMI), ever smoking. Age was independent risk factor for NERD. For silent RE, age, male gender, and frequent liquid food consumption were risk factors. Conclusions: In the population with high prevalence of ESCC, a high prevalence of GERD and inverted proportion of RE/NERD were presented. Age was an independent risk factor for GERD. The male gender, high BMI, smoking, and frequent liquid food consumption may be risk factors for RE but not for NERD.

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“…8,9 Some patients experience relentless reflux symptoms despite adequate treatment leading to doctor shopping and finally presenting with depression. 9,10 Lifestyle modifications are primal in managing initial reflux symptoms. Sadly, very few are determined to follow these routine modifications.…”

Section: Introductionmentioning

confidence: 99%

Feasibility and outcomes of anti‐reflux mucosectomy for proton pump inhibitor dependent gastroesophageal reflux disease: First Indian study (with video)

Patil

Dalal

Maydeo

2020

Digestive Endoscopy

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Background Anti‐reflux mucosectomy (ARMS) is a newfangled minimally invasive technique, with successful outcomes for the management of gastroesophageal reflux (GER). We present our initial experience (success rate) and safety profile for this procedure. Methods Consecutive patients with daily dependence on proton pump inhibitor (PPI) for GER were prospectively enrolled from September 2016 to August 2019 and underwent ARMS using a cap assisted endoscopic mucosal resection. Severity was assessed by gastroesophageal reflux disease questionnaire. Gastroscopy and 24‐h pH‐metry was done pre and post procedure. Patient characteristics, PPI requirement, adverse events and follow‐up were documented. Results Sixty‐two patients [44 (71%) male] underwent successful ARMS with a mean age (SD) of 36 (9.9) years. Technical success was achieved in 100 % of patients. Intraoperative bleeding was noted in 62 (100%) patients, endoscopic hemostasis was successfully achieved. At follow‐up dysphagia was seen in 5 (8%) patients which needed a single session of endoscopic dilation. At 2 months, mean (SD) DeMeester score normalized in 45 (72.5%) patients from 76.8 (18.3) to 14.3 (6.1) (P < 0.001). PPI could be stopped in 43 (69.4%) patients. The mean (SD) GERD‐Q score reduced from 10.6 (1.9) to 3.4 (1.5) (P < 0.001). However, in 12 (19.3%) patients low dose of PPIs was continued, while 7 (11.3%) patients continued full dose. Thirty‐eight (61.3%) patients telephonically reported symptomatic improvement and were off PPIs at 12 months. Conclusions Anti‐reflux mucosectomy is safe and effective for treatment of GER. The long term outcomes are favorable, response is durable and promising at our center. Appropriate patient selection still remains primal to the overall success of ARMS.

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Association Between Anxiety and Depression and Gastroesophageal Reflux Disease: Results From a Large Cross-sectional Study

Cited by 89 publications

References 43 publications

Depression and Anxiety in Patients with Gastroesophageal Reflux Disorder With and Without Chest Pain

Depression and Anxiety in Patients with Gastroesophageal Reflux Disorder With and Without Chest Pain

A population-based survey of gastroesophageal reflux disease in a region with high prevalence of esophageal cancer in China

Feasibility and outcomes of anti‐reflux mucosectomy for proton pump inhibitor dependent gastroesophageal reflux disease: First Indian study (with video)

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