Association between arsenic metabolism gene polymorphisms and arsenic-induced skin lesions in individuals exposed to high-dose inorganic arsenic in northwest China

Abstract

Individuals in a given environment contaminated with arsenic have different susceptibilities to disease, which may be related to arsenic metabolism, age, gender, genetics and other factors. This study recruited 850 subjects, including 331 cases and 519 controls, from populations exposed to high levels of arsenic in drinking water in northwest China. Genotypes were determined using a custom-by-design 48-Plex SNPscanTM kit. The results indicated that subjects who carried at least one C allele for GSTO1 rs11191979 polymorphism, at least one A allele for GSTO1 rs2164624, at least one A allele for GSTO1 rs4925, the AG genotype for GSTO2 rs156697, the AG genotype or at least one G allele for GSTO2 rs2297235 or the GG genotype or at least one G allele for PNP rs3790064 had an increased risk of arsenic-related skin lesions. In addition, the haplotype CT between rs4925 and rs11191979 appeared to confer a high risk of arsenic-included skin lesions (OR = 1.377, 95% CI = 1.03–1.84), as did the haplotype GCG among rs156697, rs157077 and rs2297235 (OR = 2.197, 95% CI = 1.08–4.44). The results showed that the variants of GSTO1, GSTO2 and PNP render the susceptible toward developing arsenic-induced skin lesions in individuals exposed to high-dose inorganic arsenic in northwest China.

The influence of high and low levels of arsenic in the human body on the process of carcinogenesis, based on function, expression and genetic polymorphisms in the genes encoding the two arsenic transporters - water channels AQP and glucose transporters glut (SLC2A)

“…The occurrence of arsenic in groundwater and food is associated with an increased risk of skin, liver, kidney and lung cancers as well as other diseases such as atherosclerosis and cardiovascular diseases, diabetes, hypertension and neurological diseases (Alzheimer, Parkinson). Moreover, the International Agency for Research on Cancer has put arsenic and its compounds in the group of the first carcinogenic compounds whose action has been proven epidemiologically (KULSHRESTHA et al 2014;GAMBO-LOIRA et al, 2017;LUO et al, 2018). Initially, the daily intake of arsenic was 15 μg/kg of body weight, but studies have shown that even lower doses can contribute to the development of lung, bladder and skin cancers.…”

“…It is interesting that the susceptibility to diseases associated with arsenic poisoning may vary in people of different ages, sexes or genetically adapted (LINBERG et al, 2007;ENGSTROM et al, 2007;TSENG et al, 2009;TORRES-SANCHEZ et al, 2016;LUO et al, 2018;STOJSAVLJEVIĆ et al, 2019;SOZA-RIED et al, 2019). For instance, in children an increased methylation of inorganic forms of arsenic and its urinary excretion were observed.…”

“…This findings clearly indicate that women exhibit higher arsenic methylation efficiency, manifested by a lower percentage of inorganic arsenic and methylarsonatecontent, with a concomitant higher urinary excretion of dimethylarsinate. The above was partially explained by the stimulating effects of estrogen, which promotes choline synthesis and in turn remethylate homocysteine to methionine (LINDBERG et al, 2007;ENGSTROM et al, 2007;TSENG et al, 2009;TORRES-SANCHEZ et al, 2016;LUO et al, 2018;STOJSAVLJEVIĆ et al, 2019;SOZA-RIED et al, 2019).…”

The association of tryptophan and phenylalanine are associated with arsenic-induced skin lesions in a Chinese population chronically exposed to arsenic via drinking water: a case–control study

“…As AISL are widely accepted as the major early manifestation of arsenic toxicity6 and may be an indicator of susceptibility to more serious arsenic-induced health hazards,7 it is critical to identify people who are at risk as early as possible to prevent the onset or delay the progression of serious health problems. Several possible mechanisms such as genetic differences,8 oxidative stress9 and epigenetic dysregulation10 may explain arsenic poisoning. Previous studies also suggested that arsenic methylation in vivo is associated with metabolic syndrome 11 12…”

Study on the Biosorption Performance of Penicillium chrysogenum for the Removal of Arsenic (III)

“…The accumulation of arsenic in crops and arsenic contamination in water are the main causes of arsenic poisoning and carcinogenesis [2,3] . According to the survey, the arsenic concentration in drinking water is positively correlated with the incidence of lung cancer and bladder cancer [4,5] . Microbioremediation technology has the advantages of low cost, high efficiency, no secondary pollution, and has great potential in the restoration of natural water bodies.…”