Association between asthma and caries-related salivary factors: a meta-analysis

Hatipoğlu, Ömer; Hatipoğlu, Fatma Pertek

doi:10.1080/02770903.2020.1826045

Cited by 7 publications

(6 citation statements)

References 40 publications

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“…A recent systematic review investigating the effect of asthma and salivary flow evidenced that stimulated or unstimulated flow rate was significantly reduced in asthmatic patients [30]. Another systematic review demonstrated, even with low certainty of the evidence that asthmatic children and adolescents may be more likely to build up biofilm compared to those without asthma [16].…”

Section: Discussionmentioning

confidence: 99%

“…None of the previous systematic reviews explore the use of medication by asthmatic patients, even though some stated that it is a plausible mechanism for xerostomic aspect, fact that contributes for caries development in those individuals [30]. The few and small prospective studies considering asthmatic drugs found no consensus about the effect of asthmatic drugs in caries occurrence [12, 13].…”

Section: Discussionmentioning

confidence: 99%

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Structural Relationships between Asthma and Dental Caries in Children: A Birth Cohort Study in Southern Brazil

Agostini,

Sarkis-Onofre,

Ortiz

et al. 2024

Caries Res

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Introduction: There is an inconclusive causal association between asthma symptoms and dental caries in the primary dentition. This study aimed to investigate, using SEM (structural equation modeling), a possible causal relation between asthma and dental caries in the primary dentition. Methods: Using data from the 2004 Pelotas Birth Cohort Study, a sub-sample of 1,303 individuals was selected. Dental caries was clinically evaluated at 5 years old based on decayed, missing, and filled tooth (dmft) index criteria. Asthma-related symptoms (wheezing and shortness of breath) at 1- and 4-year-olds composed a latent variable and were the main exposures to caries occurrence. SEM was used to identify possible direct, indirect, and mediated effects of asthma in primary dentition dental caries. Results: The general prevalence of caries at age 5 was 1.95 (SD: 3.56). When comparing the dmft values for children with asthma symptoms and those without, they presented similar values in both periods where asthma symptoms were evaluated (1- and 4-year-old). SEM analysis showed that asthma was neither directly nor indirectly related to dental caries. Conclusion: Asthma, using a latent variable constructed based on asthma symptoms, showed no causal effect on dental caries occurrence in the primary dentition.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Structural Relationships between Asthma and Dental Caries in Children: A Birth Cohort Study in Southern Brazil

Agostini,

Sarkis-Onofre,

Ortiz

et al. 2024

Caries Res

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“…Some dry powder inhalers are known to contain sugar to increase the tolerability of the taste of the drug when administered. Frequent oral inhalation of sugar combined with a reduced salivary flow and decreased saliva pH may contribute to an increase in dental caries [80]. Stensson et al [77] explained that this association may be due to the presence of fermentable carbohydrates, such as lactose monohydrate, in anti-asthmatic medications.…”

Section: Discussionmentioning

confidence: 99%

“…The appearance of carious lesions results from an alteration in the balance between dietary-bacterial factors, the components of the host, and the use of various medications [77,78]. The main treatment for asthma is the inhalation of steroids, and this is an important causal factor in the development of dental caries, because of the direct changes in the salivary composition that occur [79][80][81]. Several factors contribute to the increased prevalence of dental caries in asthmatic patients, such as a reduced saliva flow caused especially by beta-2 adrenergic agonists, increased counts of Streptococcus mutans and Lactobacillus spp., and a decreased salivary pH below the critical value 30 min after treatment with beta-2 agonist inhalers [22,36,73,82].…”

Section: Asthma and Dental Cariesmentioning

confidence: 99%

Drugs Prescribed for Asthma and Their Adverse Effects on Dental Health

et al. 2023

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Asthma is a chronic, heterogeneous respiratory pathology characterized by reversible airway inflammation. Therapeutics focus on symptom reduction and control, aimed at preserving normal pulmonary function and inducing bronchodilatation. The objective of this review is to describe the adverse effects produced by anti-asthmatic drugs on dental health, according to the reported scientific evidence. A bibliographic review was carried out on databases, such as Web of science, Scopus, and ScienceDirect. Most anti-asthmatic medications are administered using inhalers or nebulizers, making it impossible to avoid contact of the drug with hard dental tissues and oral mucosa, and thus promoting a greater risk of oral alterations, mainly due to decreases in the salivary flow and pH. Such changes can cause diseases, such as dental caries, dental erosion, tooth loss, periodontal disease, bone resorption, as well as fungal infections, such as oral candidiasis.

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“…The effectiveness of SBC depends on various factors such as systematic, genetic diseases, diet, hygiene habits, and medicines used [ 18 - 20 ]. Several studies have shown that salivary pH is a significant predictive factor for caries development [ 21 - 23 ], in agreement with the present study.…”

Section: Discussionmentioning

confidence: 99%

Potential Renal Acid Load, Salivary Buffer Capacity and Healthy Eating Index as Predictors of Children’s Dental Caries: A Cross-Sectional Study

Kibaroglu,

Kurt,

Demirel Özbek

et al. 2023

Cureus

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Introduction: Dental caries is one of the most common childhood diseases. This study purposed to investigate the prediction capability of potential renal acid load (PRAL), salivary buffer capacity (SBC), and Healthy Eating Index (HEI) on children's dental caries. Methods: The decay, missing, filing, and teeth for primary teeth (dmft)/Decay, Missing, Filling, and Teeth for permanent teeth (DMFT) indexes of the children aged 7-12 years who applied to our faculty were recorded. Approximately 1 mL of unstimulated saliva samples were collected, and SBC was evaluated. PRAL and HEI scores were calculated by entering the data in the form of a daily nutrition record of the children into the BeBiS software (Ebispro for Windows, Stuttgart, Germany). The association of dental caries indices with PRAL, SBC, and HEI was analyzed using an independent sample t-test. A binomial logistic regression analysis was performed to predict the dental caries burden. The statistical significance level was adjusted to a=0.05. Results: A total of 150 children, 88 (58.6%) females and 62 (41.4%) males, were included in the study. Significant differences were found between the low and high dental caries groups for dmft regarding PRAL and SBC (p<0.001). A significant difference was found between the low and high dental caries groups for DMFT in terms of SBC (p<0.05). Conclusion: In our study, established regression models significantly predicted dental caries in primary teeth. SBC was the most influential factor in predicting dental caries compared to PRAL and HEI. There was a significant relationship between SBC, PRAL, and caries in primary teeth. In the model we created, the strongest predictor was SBC.

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Association between asthma and caries-related salivary factors: a meta-analysis

Cited by 7 publications

References 40 publications

Structural Relationships between Asthma and Dental Caries in Children: A Birth Cohort Study in Southern Brazil

Structural Relationships between Asthma and Dental Caries in Children: A Birth Cohort Study in Southern Brazil

Drugs Prescribed for Asthma and Their Adverse Effects on Dental Health

Potential Renal Acid Load, Salivary Buffer Capacity and Healthy Eating Index as Predictors of Children’s Dental Caries: A Cross-Sectional Study

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