Association between basal metabolic function and bone metabolism in postmenopausal women with type 2 diabetes

Ogata, Makiko; Ide, Risa; Takizawa, Miho; Tanaka, Mizuho; Tamaki, Takehiro; Sato, Asako; Iwasaki, Naoko; Uchigata, Yasuko

doi:10.1016/j.nut.2015.06.012

Cited by 14 publications

(24 citation statements)

References 90 publications

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“…Conversely, a recent study has indicated the role of OC in replication of beta-cells and insulin secretion and on the other hands role of insulin in activation of OC [32]. The physiologic relevance of this finding has been confirmed by other studies which demonstrated the association between hyperglycemia and bone markers [33, 34]. Nevertheless in agreement with our findings, others have reported no association between bone markers and hyperglycemia.…”

Section: Discussionsupporting

confidence: 90%

The association between bone turnover markers and microvascular complications of type 2 diabetes

Maghbooli

Shabani

Gorgani‐Firuzjaee

et al. 2016

J Diabetes Metab Disord

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BackgroundGlobal epidemic of diabetes is a serious health care concern because of its complications and consequently reduced life expectancy and increased morbidity. However, the bone turnover and thus bone health may be affected or even compromised by diabetes and its complications. The aim of this study was to assess whether bone turnover markers are associated with diabetes micro-vascular complications.MethodsA total of 204 type 2 diabetes patients (104 patients with diabetic micro-vascular complications (retinopathy and/or nephropathy) as a case group and 100 patients without retinopathy and/or nephropathy) as a control group were recruited in this case–control study. The biochemical and metabolic parameters and bone turnover markers were assessed in all patients.ResultsOur findings showed serum levels of osteocalcin (OC) (p = 0.0001) and, carboxy-terminal collagen crosslinks (CTX) (p = 0.006) were higher in diabetic patients with both diabetic retinopathy and nephropathy compared with control group. However, there was no significant difference in serum levels of procollagen I aminoterminal propeptide (P1NP) between diabetic patients with diabetic retinopathy (DR) and/or diabetic nephropathy (DN) compared with control.In diabetes patients with complications, there were significant negative correlation between OC and CTX with estimated-glomerular filtration rate (e-GFR) and also positive correlation between each bone marker (OC and CTX) and PTH levels (p = 0.0001) and BUN (p = 0.0001).In a general linear model, after adjusting for age, sex and BMI, and microvascular complications, there was not any significant association between three bone turnover markers and metabolic markers including fasting glucose, insulin, and lipid profile. Among kidney markers, there were significant positive associations between serum levels of CTX and OC with BUN (p < 0.05) as well as PTH (p < 0.0001).ConclusionsOur data suggest the possible role of PTH and BUN levels in modulating bone turnover markers in diabetic patients.

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Section: Discussionsupporting

confidence: 90%

The association between bone turnover markers and microvascular complications of type 2 diabetes

Maghbooli

Shabani

Gorgani‐Firuzjaee

et al. 2016

J Diabetes Metab Disord

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“…Among the several biochemical markers of bone turnover, β-CTx and P1NP are markers of the resorption and formation of collagen, and are believed to reflect the early changes during bone turnover [21]. P1NP is a circulating protein released by the osteoblasts during the synthesis of collagen type I and is predominantly located in the bone matrix [22].…”

Section: Discussionmentioning

confidence: 99%

“…P1NP is a circulating protein released by the osteoblasts during the synthesis of collagen type I and is predominantly located in the bone matrix [22]. Previous studies have shown that P1NP levels are lower in postmenopausal women with T2DM [23], and that P1NP levels are significantly and negatively correlated with the initial HbA1C levels and the duration of diabetes in postmenopausal women [21]. In our study, we found that on average, DME patients had lower P1NP levels; there was no significant difference in the mean P1NP levels between subjects with and without DR.…”

Section: Discussionmentioning

confidence: 99%

Association of Bone Metabolic Markers With Diabetic Retinopathy and Diabetic Macular Edema in Elderly Chinese Individuals With Type 2 Diabetes Mellitus

Zhang

Yang

Zhong

et al. 2017

The American Journal of the Medical Sciences

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Background Diabetic retinopathy (DR) is a common and specific microvascular complication of diabetes. The association of bone metabolic markers with the risk of DR and diabetic macular edema (DME) is unclear. Materials and Methods We investigated the association between bone turnover markers commonly examined in a clinical setting and DR and DME risk in elderly Chinese patients with type 2 diabetes mellitus (T2DM). A total of 408 patients aged 55 to 70 years old with T2DM were included. We first performed univariable logistic regression followed by multivariable logistic regression that included variables selected using purposeful selection. Results Fasting blood glucose (P=0.007) and duration of diabetes (P<0.0001) were significantly associated with DME in multivariable logistic regression; however, the association of β-CTx with DME risk was not statistically significant (P=0.053). Sex-stratified analysis showed that β-CTx was significantly associated with DME only in female subjects (P=0.011). Conclusions β-CTx had no significant association with DR. It was significantly associated with DME in female T2DM patients but not in male T2DM patients. More prospective studies with larger sample sizes are warranted to validate our findings.

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“…Ten studies have reported on a relationship between BTMs and BMD. 12,[17][18][19][20][21][22][23][24][25] Among them, three studies were conducted in Asia, including two articles in Japan that failed to show a significant relationship in men and women and one article in China that revealed different relationships in different kinds of BTMs in postmenopausal women (negative or positive). Studies from other continents also reported controversial results.…”

Section: Introductionmentioning

confidence: 99%

Association between serum levels of bone turnover markers and bone mineral density in men and women with type 2 diabetes mellitus

Zhao

Liu

Zhang

et al. 2019

Clinical Laboratory Analysis

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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractBackground: In patients with type 2 diabetes mellitus (T2DM), higher risks of impaired bone metabolism are widely reported. To evaluate bone metabolism, bone mineral density (BMD) and bone turnover levels should be included. In this article, we analyzed the relationship between them in T2DM. Methods:We conducted a hospital-based cross-sectional study enrolling 1499 patients hospitalized for T2DM between October 2009 and January 2013. Multivariate linear regression models were used to identify the relationship between bone turnover markers (BTMs) and BMD levels. A two-sided P-value < .05 was considered statistically significant. Results:After adjusting for confounding factors, osteocalcin (OC) showed a negative relationship with total lumbar, femur neck, and total hip BMD in men and women. N-terminal propeptides of type I collagen (P1NP) and alkaline phosphatase (ALP) showed a negative association with BMD at three sites in men and total lumbar BMD in women, whereas in the femur neck and total hip in women, the relationship was only found for P1NP with total hip. For β-C-terminal telopeptides of type I collagen (β-CTX), a negative relationship was also found in all three sites for BMD in men and total lumbar BMD in women, whereas β-CTX was not associated in the femoral neck and total hip in women. Conclusion:In patients with T2DM, serum levels of OC, P1NP, β-CTX, and ALP were negatively correlated with BMD levels in men in three sites and with total lumbar BMD in women. The relationship varied in femur neck and total hip BMD in women. K E Y W O R D Sbone mineral density, bone turnover markers, type 2 diabetes mellitus Chenhe Zhao and Guangwang Liu contributed equally to this work.

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Association between basal metabolic function and bone metabolism in postmenopausal women with type 2 diabetes

Cited by 14 publications

References 90 publications

The association between bone turnover markers and microvascular complications of type 2 diabetes

The association between bone turnover markers and microvascular complications of type 2 diabetes

Association of Bone Metabolic Markers With Diabetic Retinopathy and Diabetic Macular Edema in Elderly Chinese Individuals With Type 2 Diabetes Mellitus

Association between serum levels of bone turnover markers and bone mineral density in men and women with type 2 diabetes mellitus

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