Association Between BMI and Metabolic Syndrome and Adenomatous Colonic Polyps in Korean Men

Lee, Go-Eun; Park, Hye-Sang; Yun, Kyung E.; Jun, Sung H.; Kim, Hong; Cho, Sung-Il; Kim, Jin Hee

doi:10.1038/oby.2008.216

Cited by 74 publications

(63 citation statements)

References 35 publications

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“…In addition, MetS-component numbers were reported in many convincing studies that closely linked them with damaged conditions of the whole human body: impaired cardiovascular conditions [32,33] , cognitive impairment [34] , and colon polyps [35] . Shift work is associated with the premature aging process [36] , and as demonstrated in our analyses (Table 4 and Figure 1), the e-ATL-plus-pRSW workers had significantly increased numbers of MetScomponents in the end of follow-up.…”

Section: Increasing Mets-component Numbers and Development Of Mets Ammentioning

confidence: 99%

Shift work aggravates metabolic syndrome developmentamong early-middle-aged males with elevated ALT

Lin¹,

Hsiao²,

Chen³

2009

WJG

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AIM:To examine whether shift work accelerates metabolic syndrome (MetS) development among early middle-aged males with elevated alanine aminotransferase (e-ALT). METHODS:A retrospective, observational followup study on MetS development at a 5-year interval was conducted using health examination data. Nine hundred and ninety six male employees not fulfilling MetS criteria at screening were enrolled. Age, MetScomponents, liver enzymes, serological markers for viral hepatitis, abdominal ultrasound, insulin resistance status, lifestyles, and workplace factors were analyzed. RESULTS:The prevalence of elevated serum ALT (> 40 U/L, e-ALT) at baseline was 19.1%. There were 381 (38.3%) workers with long-term exposures to daynight rotating shift work (RSW). 14.2% of subjects developed MetS during follow-up. After 5 years, the workers with e-ALT had significantly unfavorable changes in MetS-components, and higher rates of MetS development, vs subjects with normal baseline ALT levels. Workers with both baseline e-ALT and 5-year persistent RSW (pRSW) exposure had the highest rate of MetS development. Also, e-ALT-plus-pRSW workers had a significant increase in MetS-components at follow-up, compared with the other subgroups. After controlling for potential confounders, e-ALT-plus-pRSW workers posed a significant risk for MetS development (odds ratio, 2.7; 95% confidence interval, 1.4-5.3, vs workers without baseline e-ALT nor pRSW). CONCLUSION:We suggest that all early middleaged male employees with e-ALT should be evaluated and managed for MetS. Particularly in terms of job arrangements, impacts of long-term RSW on MetS development should be assessed for all male employees having baseline e-ALT.

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Section: Increasing Mets-component Numbers and Development Of Mets Ammentioning

confidence: 99%

Shift work aggravates metabolic syndrome developmentamong early-middle-aged males with elevated ALT

Lin¹,

Hsiao²,

Chen³

2009

WJG

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“…As for the association between obesity and colorectal adenomatous polyps, even though most epidemiological studies including cross-sectional studies, case-control studies, and cohort studies (11)(12)(13)(14)(15)(16)(17)(18)(19)(20) reported a positive association, several studies (20)(21)(22)(23)(24)(25) showed no significant association. Moreover, the findings on the relationship between obesity and the risk of colorectal polyps were inconsistent by gender (12,14,15,19) or types of body measures for obesity such as BMI and WC (12,19).…”

Section: Introductionmentioning

confidence: 99%

Obesity and colorectal adenomatous polyps: A cross-sectional study in Korean adults

Lee

Kwak

Myung

et al. 2013

Obesity

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Objective: This study aimed to examine the association between obesity and the risk of colorectal adenomatous polyps. Design and Methods: The design of this study is a cross-sectional study. A total of 1,574 participants (818 males and 756 females), who had undergone colonoscopy for health examinations at the National Cancer Center hospital in South Korea from February to September 2009, were included in the analysis. Results: The prevalence of colorectal adenomatous polyps was 39.5% in males and 22.6% in females. In multiple logistic regression analysis, obesity (odds ratio [OR] ¼ 1.69, 95% CI ¼ 1.16-2.48) and abdominal obesity (OR ¼ 1.59, 95% CI ¼ 1.13-2.23) were significantly associated with an increased risk of colorectal adenomatous polyps in males, but not in females. In the subgroup analyses by age, obesity (OR ¼ 2.27, 95% CI ¼ 1.32-3.89), and abdominal obesity (OR ¼ 1.76, 95% CI ¼ 1.12-2.76) significantly increased a risk of colorectal adenomatous polyps in males aged <50 years, but not in males aged 50 years. However, interaction terms were not significant between obesity and gender (P ¼ 0.397) and between obesity and age (P ¼ 0.531) in the overall analyses.

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“…İnsülin normal mukozada apoptozu azaltarak kolorektal adenomdan kanser gelişme zincirini uyarabilir [1,5,8] [1,7,18].…”

Section: İnsülin Direnci Ve Insülin Büyüme Faktörü Bağlayıcı Proteinunclassified

“…70 yaş üzerinde ise prevalans kadınlarda %70, erkeklerde %49 bulunmuştur [4]. MS, santral obezite, bozulmuş glukoz toleransı, HT, hipertrigliseridemi, yüksek yoğunluklu lipoprotein kolesterol (HDL-K) düşüklüğü ile karekterizedir [1,3,5]. İnsülin direnci, dolaşımda yüksek insülin düzeyi ile karakterize prediyabetik bir durumdur.…”

Section: Introductionunclassified

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Kolorektal karsinogenez ve metabolik sendrom ilişkisi

Erarslan¹,

Yüksel²,

Haznedaroğlu³

2012

CMJ

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Metabolik sendrom obezite, dislipidemi, hiperglisemi ve hipertansiyon gibi hastalıkların toplamından oluşur. Metabolik sendrom bileşenlerinin çoğu tümör gelişimi ile bağlantılıdır. Metabolik sendrom ve visseral obezitenin genel populasyonda sıklık ve yaygınlığı giderek artmaktadır. Obezite son zamanlarda kanserlerin çoğunda mortalite ile bağlantılıdır. Kolorektal kanser önemli bir halk sağlığı problemidir. Son raporlar metabolik sendromlu bireylerde kolon veya rektum kanseri riskinin yüksek olduğunu göstermiştir. Metabolik sendrom ve kolorektal kanser arasındaki bağlantının patofizyolojik mekanizması çoğunlukla abdominal obezite ve insülin direnci ile ilişkilidir. Beslenme, egzersiz ve stresi azaltmayı kapsayan multidisipliner bir yaklaşım insülin direncini sınırlamada ve kanser sonuçlarını iyileştirmede çok önemli bir fırsat olabilir.Anahtar sözcükler: Metabolik sendrom, kanser, insülin direnci, obezite AbstractMetabolic syndrome consists of a cluster of diseases including obesity, dyslipidemia, hyperglycemia and hypertension. Most of the components of metabolic syndrome have been associated with the development of neoplasm. The metabolic syndrome and visceral obesity have an increasing prevalence and incidence in the general population. Obesity has recently been linked to mortality in the majority of cancers. Colorectal cancer is an important public health problem. Recent reports in individuals with metabolic syndrome showed a high risk of colon or rectal cancer. The pathophysiological mechanism that links metabolic syndrome and colorectal cancer is mostly related to abdominal obesity and insulin resistance. A multidisciplinary approach involving nutrition, exercise, and stress reduction may be an opportunity to limit the insulin-resistant state and improve cancer outcomes.

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Association Between BMI and Metabolic Syndrome and Adenomatous Colonic Polyps in Korean Men

Cited by 74 publications

References 35 publications

Shift work aggravates metabolic syndrome developmentamong early-middle-aged males with elevated ALT

Shift work aggravates metabolic syndrome developmentamong early-middle-aged males with elevated ALT

Obesity and colorectal adenomatous polyps: A cross-sectional study in Korean adults

Kolorektal karsinogenez ve metabolik sendrom ilişkisi

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