Obesity and colorectal adenomatous polyps: A cross-sectional study in Korean adults

Lee, Jun-Young; Kwak, Sang Mi; Myung, Seung‐Kwon; Jee, Sun Ha

doi:10.1002/oby.20390

Cited by 13 publications

(7 citation statements)

References 32 publications

(51 reference statements)

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“…We also did not find an association between overweight and/or obese with the prevalence of colorectal adenomas in the current analysis. Differences between our study and these studies [20][21][22] include: (1) study settings where we performed a case-control study among individuals who underwent a colorectal screening program using iFOBT test and colonoscopy while these studies were among those who underwent the colonoscopy only, and (2) these studies [20][21][22] We found that underweight among male individuals were significant associated with colorectal adenomas prevalence in the current study, which is inconsistent with prior studies that overweight and/or obese increased risk of colorectal adenomas in both sexes in non-Asian populations. [13][14][15]25,26 This association was observed particularly among ethnically diverse population 26 and among obese but metabolically healthy individuals.…”

Section: Discussioncontrasting

confidence: 71%

Association between body mass index and colorectal adenomas: Findings from a case‐control study in Vietnam

Luu

Tran²,

Nguyen³

et al. 2021

Intl Journal of Cancer

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Colorectal cancer is a leading cancer worldwide and in Vietnam. Adenomas (adenomatous polyps) is an important precursor of colorectal cancer. There is currently no study to determine the modifiable risk factors for colorectal adenomas, including body mass index (BMI) in Vietnam. We conducted an individually matched case-control study of 1149 colorectal adenomas and 1145 controls in a large-scale colorectal screening program involving 103 542 individuals aged 40-75 years old in Hanoi, Vietnam. Conditional logistic regression was used to evaluate the association between BMI and colorectal adenomas prevalence, after controlling for potential confounders. Overall, comparing to normal weight (ie, 18.5-22.9 kg/m 2 ), underweight (ie, BMI < 18.5) was associated with a non-statistically significant increased prevalence of colorectal adenomas (odd ratio [OR] = 1.29 and 95% confident interval [CI]:

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Section: Discussioncontrasting

confidence: 71%

Association between body mass index and colorectal adenomas: Findings from a case‐control study in Vietnam

Luu

Tran²,

Nguyen³

et al. 2021

Intl Journal of Cancer

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“…This obesity-related factor indicates that not only maintaining a normal BMI, but also keeping WC at ≤89.9 cm is important. Previous studies found that WC ≥90.0 cm increases the risk of polyp incidence by 1.59 times [30].…”

Section: Discussionmentioning

confidence: 90%

Colorectal Polyp Prevalence According to Alcohol Consumption, Smoking and Obesity

Lee

Kim

2020

IJERPH

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This study aimed to analyze colorectal polyp prevalence associated with health behavior. Data from 1180 Korean men (young adult (YA), aged 40–49; middle age (MA) aged 50–59; old aged (OA), aged 60–79 years) were collected. Health behavior included alcohol consumption, smoking status, and obesity. Obesity was determined using body mass index (BMI) and waist circumference (WC). Odds ratio (OR) was calculated by logistic regression. The prevalence of polyps increased for current smokers by 2.642 times in the YA group, 3.468 times in the MA group, and 3.104 times in the OA group compared to the never-smokers. The OR for WC increased in subjects with obesity by 1.514 in the MA and 1.451 in the OA group compared to normal. The prevalence of three or more polyps increased with WC obesity by 2.3 times in YA, 2.2 times in MA, and 1.9 times in OA compared to normal WC. Therefore, smoking cessation and obesity management may reduce the risk of colorectal polyps.

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“…Obesity is a known risk factor for higher incidence of colorectal adenomas, advanced colorectal adenomas, and CRC. 2,3 Most studies assessing the influence of obesity on CRC, as well as on other diseases, employ body mass index (BMI) as an indicator of body fat and obesity. However, precise interconnections between BMI and CRC are still vague.…”

Section: Introductionmentioning

confidence: 99%

Clinical stages of colorectal cancer diagnosed in obese and overweight individuals in the Polish Colonoscopy Screening Program

et al. 2019

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Background Obesity is a known risk factor of colorectal cancer (CRC). However, precise interconnections between excessive body fat and CRC are still vague. Therefore, the aim of this study was to assess whether stage of CRC detected in overweight and obese individuals differs from individuals with normal body mass index (BMI). A secondary aim of this study was to elucidate whether overweight and obesity influence the overall survival in CRC. Methods This study was a cross-sectional analysis of 163,129 individuals who underwent screening colonoscopy performed on data from a prospectively maintained database of the Polish Colonoscopy Screening Program. Results Overweight and obese individuals present with a less advanced CRC in screening setting ( p = 0.014). This trend is the most pronounced in males ( p = 0.001). Univariable and multivariable analyses revealed that obesity was a negative predictor of detection of advanced CRC with odds ratio 0.72 (95% confidence interval 0.52–1.00; p = 0.047). Furthermore, overweight and obesity were not statistically significant predictors of risk of death ( p = 0.614 and p = 0.446, respectively). Conclusions Obese screenees present with a less advanced disease in comparison to non-obese. Moreover, survival stratified by clinical stage seems to not be influenced by BMI category. Therefore, a higher proportion of early diagnosed cancers can potentially create a survival benefit in this group.

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Obesity and colorectal adenomatous polyps: A cross-sectional study in Korean adults

Cited by 13 publications

References 32 publications

Association between body mass index and colorectal adenomas: Findings from a case‐control study in Vietnam

Association between body mass index and colorectal adenomas: Findings from a case‐control study in Vietnam

Colorectal Polyp Prevalence According to Alcohol Consumption, Smoking and Obesity

Clinical stages of colorectal cancer diagnosed in obese and overweight individuals in the Polish Colonoscopy Screening Program

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