Association between body mass index and colorectal adenomas: Findings from a case‐control study in Vietnam

Abstract

Colorectal cancer is a leading cancer worldwide and in Vietnam. Adenomas (adenomatous polyps) is an important precursor of colorectal cancer. There is currently no study to determine the modifiable risk factors for colorectal adenomas, including body mass index (BMI) in Vietnam. We conducted an individually matched case-control study of 1149 colorectal adenomas and 1145 controls in a large-scale colorectal screening program involving 103 542 individuals aged 40-75 years old in Hanoi, Vietnam. Conditional logistic regression was used to evaluate the association between BMI and colorectal adenomas prevalence, after controlling for potential confounders. Overall, comparing to normal weight (ie, 18.5-22.9 kg/m 2 ), underweight (ie, BMI < 18.5) was associated with a non-statistically significant increased prevalence of colorectal adenomas (odd ratio [OR] = 1.29 and 95% confident interval [CI]:

Independent and joint associations of general and abdominal obesity with the risk of conventional adenomas and serrated polyps: A large population‐based study in East Asia

“…Among them, several studies have found the significant positive association of general obesity with the risk of ADs in different populations, [25][26][27][28] nevertheless, other studies showed this positive association but did not achieve statistical significance. 29,30 The findings were similar for its association with the risk of SPs. [31][32][33] Moreover, there are also studies investigating these two lesions simultaneously.…”

“…Over the past two decades, the association of general obesity with the risk of colorectal precancerous lesions was largely performed in single type. Among them, several studies have found the significant positive association of general obesity with the risk of ADs in different populations, 25‐28 nevertheless, other studies showed this positive association but did not achieve statistical significance 29,30 . The findings were similar for its association with the risk of SPs 31‐33 .…”

“…19,34,35 To date, the positive association of abdominal obesity with the risk of ADs has been found to be significant in some studies, 30,36,37 but not in others. 30,38,39 There are few studies exploring its association with the risk of SPs, which indicate the nonsignificant positive association. 40,41 As for these two lesions concurrently, only one study has been performed in Israel, which included 75 SPs and 347 ADs and showed the significant association with ADs but not with SPs.…”

“…It is valuable to note that the prevalence of general obesity in Asian population is typically lower than that of European or American population, but higher prevalence of abdominal obesity was exhibited in Asian population 19,34,35 . To date, the positive association of abdominal obesity with the risk of ADs has been found to be significant in some studies, 30,36,37 but not in others 30,38,39 . There are few studies exploring its association with the risk of SPs, which indicate the nonsignificant positive association 40,41 .…”

Obesity and incidence of colorectal polyps: a case-controlled study

“…Further, a more recent study in 2021 has declared the reciprocal relation between BMI and the incidence rate of colorectal polyps. Namely, authors have claimed that thinner patients with lower BMI values manifested a higher explosion rate of colorectal polyps, although no data about histopathological changes was explained 25 .…”