Association between body fat parameters and arterial stiffness

Kim, Hack‐Lyoung; Ahn, Dong-Won; Kim, Su Hwan; Lee, Dong Seok; Yoon, Soon Ho; Zo, Joo Hee; Kim, Myung‐A; Jeong, Ji Bong

doi:10.1038/s41598-021-00175-z

Cited by 40 publications

(42 citation statements)

References 40 publications

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“…In our study, BAPWV tended to rise significantly with an increase in BMI; however, this was not clear. A recent study [ 38 ] did not find any significant correlation between BAPWV and BMI, suggesting that arterial stiffness may have a weaker association with the overall obesity status. While our study showed a linear relationship between BMI class and BAPWV, this was only apparent for younger males aged <50 years ( p = 0.01) and older females aged ≥ 50years ( p < 0.01).…”

Section: Discussionmentioning

confidence: 96%

Association between Brachial-Ankle Pulse Wave Velocity as a Marker of Arterial Stiffness and Body Mass Index in a Chinese Population

Zuo

Tang

O’Rourke

et al. 2022

JCDD

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Objectives: Arterial stiffness is widely accepted as an important predictor of cardiovascular disease (CVD) development. While obesity is generally associated with increased CVD risk, there is evidence that overweight patients with existing CVD may have better clinical outcomes than their lean counterparts. Our study sought to observe any potential association between brachial–ankle pulse wave velocity (BAPWV), a marker of arterial stiffness related to CVD risk, and Body Mass Index (BMI), a crude and widely used measure of obesity. Methods: Adult individuals (n = 857) assessed for routine CV risk were included and grouped according to their BMI (<25 kg/m2: normal; 25–30 kg/m2: overweight, ≥30 kg/m2: obese). Their anthropometric parameters, brachial cuff pressures, and BAPWV were measured. Results: Brachial pressure was significantly higher as BMI increased. BAPWV showed a positive linear association with systolic (r = 0.66, p < 0.01), mean (r = 0.60, p < 0.01), diastolic (r = 0.51, p < 0.01), and pulse (r = 0.53, p < 0.01) pressures. However, a linear relationship between BMI and BAPWV was only apparent in males aged <50 years (p = 0.01) and in females aged ≥50 years (p < 0.01). In individuals with similar brachial systolic pressure, BAPWV was higher in normal-weight subjects compared to overweight–obese ones. Conclusions: This conflicting finding is attributed to an overestimation of the degree of arterial stiffness as a measure of CVD risk in individuals with a less ‘healthy’ BMI. This suggests that BMI may not the appropriate obesity indicator to assess CV risk. Our finding emphasizes the importance of establishing a non-linear relationship between CVD risk, age, and BMI, taking into account apparent sex differences, to predict future CV events. While this finding may suggest a lower degree of stiffness in large arteries of overweight–obese subjects compared to their normal-weight counterparts, the potential implications for individuals with higher BMI need be explored further.

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Section: Discussionmentioning

confidence: 96%

Association between Brachial-Ankle Pulse Wave Velocity as a Marker of Arterial Stiffness and Body Mass Index in a Chinese Population

Zuo

Tang

O’Rourke

et al. 2022

JCDD

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“…When considering abdominal obesity, it has been shown that in obese patients the PWV is significantly higher compared to normal healthy individuals, proving that abdominal obesity is a significant factor in the development of AS [ 48 , 49 , 50 ]. BMI, visceral fat thickness, and fat mass are the strongest body fat measures related to PWV [ 51 , 52 , 53 ].…”

Section: Impact Of Metabolic Syndrome Components On Arterial Stiffnessmentioning

confidence: 99%

“…For every 1 cm/s increase in PWV, SBP, as well as DBP, increased by 5.60 and 2.12 mmHg, respectively. [49] PWV was shown to be significantly associated with a higher waist-to-hip ratio (WHR) [for >0.90 in men and >0.85 in women: odds ratio (OR) 1.23; 95% confidence interval (CI) 1.06-1.42; p = 0.005; for the highest tertile compared to the lowest tertile: OR 1.38; 95% CI 1.15-1.66; p < 0.001], and with higher visceral fat area (VFA) (for ≥100 cm 2 : OR 1.39; 95% CI 1.20-1.60; p < 0.001; for the highest tertile compared to the lowest tertile: OR 1.77; 95% CI 1.48-2.12; p < 0.001).…”

Section: Elevated Blood Pressurementioning

confidence: 99%

Arterial Stiffness Assessment by Pulse Wave Velocity in Patients with Metabolic Syndrome and Its Components: Is It a Useful Tool in Clinical Practice?

Starzak

Stanek

Jakubiak

et al. 2022

IJERPH

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Metabolic syndrome (MS) is not a single disease but a cluster of metabolic disorders associated with increased risk for development of diabetes mellitus and its complications. Currently, the definition of MS published in 2009 is widely used, but there are more versions of the diagnostic criteria, making it difficult to conduct scientific discourse in this area. Increased arterial stiffness (AS) can predict the development of cardiovascular disease both in the general population and in patients with MS. Pulse wave velocity (PWV), as a standard method to assess AS, may point out subclinical organ damage in patients with hypertension. The decrease in PWV level during antihypertensive therapy can identify a group of patients with better outcomes independently of their reduction in blood pressure. The adverse effect of metabolic disturbances on arterial function can be offset by an adequate program of exercises, which includes mainly aerobic physical training. Non-insulin-based insulin resistance index can predict AS due to a strong positive correlation with PWV. The purpose of this paper is to present the results of the review of the literature concerning the relationship between MS and its components, and AS assessed by PWV, including clinical usefulness of PWV measurement in patients with MS and its components.

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“…Another study 9 demonstrated that the greater the muscle mass, the lower the arterial stiffness in long-lived adults, with no statistical relationship between PWV and body composition. On the other hand, another study 10 showed an association of PWV with WC, waist-hip ratio, and visceral fat area, but not with body mass index (BMI); in the multivariate analysis, only waist-hip ratio and visceral fat area were associated with PWV.…”

mentioning

confidence: 91%

“…Studies [8][9][10][11][12][13] on the association between arterial stiffness, BP and anthropometric and metabolic variables have yielded varied results; it is believed that the combined action of CV risk factors is the main determinant of vascular damage. 5 In the elderly, a study 8 reported significant associations between PWV, age, BP, WC, fat body mass, and leptin.…”

mentioning

confidence: 99%