Association Between Body Mass Index and Male Sperm Apoptosis and Apoptosis-Related Factors

Zhu, Guangli; Zhang, Yuting; Dong, Jianjun; Liu, Yilin; Zhao, Fang; Li, Ting; Shi, Zhanrong; Zhang, Yanping; Song, Na; Song, Wenya; Lv, Yuzhen

doi:10.2147/dmso.s289923

Cited by 14 publications

(7 citation statements)

References 35 publications

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“…Thus, VEGF-A being present in the greatest concentrations within SP is not entirely surprising. Furthermore, research has demonstrated a decrease of VEGF-A in the SP of obese humans causing a negative effect on semen quality (Zhu et al, 2021). Our study agrees with these results since VEGF-A had one of the lowest VIP impacts of all the cytokines presented, more specifically during the LR and GO treatment.…”

Section: Discussionsupporting

confidence: 91%

The effects of nutritional level and body condition score on cytokines in seminal plasma of beef bulls

Harrison

Chaney²,

Brandt³

et al. 2023

Front. Anim. Sci.

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IntroductionHigh quality semen is essential for reproductive efficiency. Nutrition and environmental factors impact the ejaculate components, like cytokines, that are essential for pregnancy establishment. We hypothesized that differing nutritional periods and body condition scores would affect seminal plasma cytokine concentrations of bulls.MethodsMature Angus bulls (n=11) were individually housed and randomly assigned to either over-fed (n=5) or restricted (n=6) treatment pathways. Bulls were fed different volumes of a single ration creating 8 individual treatment periods. Body weight and body condition scores were taken every 14 d to manage intake volumes. Ejaculates were collected every 84 d to determine seminal plasma cytokine profiles. A complete randomized design was used to evaluate seminal plasma cytokines after each nutritional treatment. Initial cytokine concentrations and volume of the ejaculate were included as covariates.ResultsAll cytokines returned to initial concentrations following maintenance treatments at an ideal body condition score of 6. Nutritional treatments affected (P ≤ 0.05) IFN-γ, IL-8, MIP-1α, MIP-1β, TNF-α, IL-1β, and VEGF-A. However, TNF-α, IFN-γ, and MIP-1α had the greatest impact on cytokine profile.DiscussionNutritional levels and adiposity altered seminal plasma cytokine concentrations which could potentially impact the inflammatory balance of the uterus and the immune responses necessary for pregnancy establishment.

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Section: Discussionsupporting

confidence: 91%

The effects of nutritional level and body condition score on cytokines in seminal plasma of beef bulls

Harrison

Chaney²,

Brandt³

et al. 2023

Front. Anim. Sci.

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“…Some authors observed favourable effect of alcohol on semen parameter in moderate amount (22) Semen volume, sperm count, motility, and morphology are affected by alcohol(23). Sperm apoptosis was signi cantly increased in overweight and obese men compared with men with normal BMI (25). Alterations in morphology and decreased concentration, motility, and viability have been observed among smokers.…”

Section: Discussionmentioning

confidence: 97%

Prevalence of abnormal semen parameter among the male partner of infertile couple and factors associated with abnormal semen parameter

Panda¹,

AGARWAL²,

Das³

et al. 2022

Preprint

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This is a hospital-based observational study to estimate the prevalence of abnormal semen parameters in the northeast part of India and the effect of aging, lifestyle, and habits associated with it. Methodology- This study was conducted among the male partner of the infertile couple who attended our infertility clinic from Jan 2019 to July 2021. After written consent semen samples were collected and analyzed in our andrology lab based on the 2010 WHO recommendation. For each male partner two consecutive sample collected one month apart and the study result was mean of two sample analysis. Result of seminal analysis,.age, lifestyle, habits, and occupational exposure associated with different semen parameters were collected and analyzed by using SPSS Software version 22, with unpaired T test and Logistic regression analysis. RESULT In this study 14.8% males had oligospermia, 14.2% had Semen volume < 1.5ml,51..8% had total motility less than 50% ,(62.2%) had progressive motility less than 32%.and23.3.% had normal morphology < 4% and 25.6% had vitality < 58% .Semen volume was reduced in the age group more than 40 years (P value 0.000 ExpB 2.6) and with smoking (ExpB1.99). Sperm count was significantly less in the age group > 40years and with smokers( P VALUE-0.000,.0.012)Reduction in BMI increases sperm concentration. Smoking affects the total motility of sperms (ExpB 1.873). Progressive motility was affected by smoking and alcohol ( P value 0.000,0.000 ExpB 2.19,2.02). Vitality was affected by smoking, alcohol, and increased BMI (p-value 0.010,0.041, 0.000, ExpB 1.27.1.3,1.1). Morphology was affected by smoking, alcohol, (p-value − 0.00, 0.000, ExpB 1.57, 1.13) and with exposure to pesticide Conclusion– Increased age above forty affect semen volume, and sperm count. Increased BMI negatively associated with sperm count, vitality ,and morphology. Alcohol intake affects progressive motility,vitality and morphology.Smoking affect all parameter of semen,and exposure to pesticide increases abnonrmal morphology

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“…In fact, high fat consumption reshapes the fatty acid composition of sperm by altering their metabolism in the testis (Andersen et al, 2016). Sperm DNA fragmentation is also increased in ejaculated semen of obese subjects (Zhu et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Kefir milk consumption decreases sperm alterations due to the high‐fat diet in adult male rats

et al. 2022

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Over the past decades, an increase of male infertility through the decrease of sperm count has been noted. It has been suggested that environmental factors and lifestyle could a negative impact over sperm quality. Among these factors, the consumption of foods high in fat, which leads to overweight and obesity, can negatively influence fertility. The present study was designed to highlight the protective effect of Kefir, natural probiotic, against the decline in sperm quality related to fat high diet. Thirty adult rats were divided into four groups: Control (1 ml/100 g of body weight (bw) of semi‐shimmed cow milk), KM (1 ml/100 g bw of Kefir milk), HFD (1 ml/100 g bw of semi‐shimmed cow milk + high‐fat diet) and KM/HFD (1 ml/100 g bw Kefir milk + high‐fat diet). After 60 days of treatment, sperm quality, biochemical assays of lipids profil, blood cell count and histological examination in testis were assessed. The results described an improved of sperm density (64.28 106 ml vs 54.14 106 ml), viability (70.50% vs 55.33%), mobility (65.40% vs 63.60%) and morphological abnormalities (52% vs 25%) in the KM/HFD group compared to HFD group. In the same group, the lipid profil (Triglycerides (128.39 mg/dl vs 102.85 mg/dl), C‐LDL (13.65 mg/dl vs 15.32 mg/dl) and C‐HDL (23.21 mg/dl vs 19.15 mg/dl)) was corrected compared to HFD group. The histological observation of testis revealed a normal spermatogenesis compared to seminiferous tubules of HFD group, which showed a serious disruption and damage of testicular epithelium exerted by the high‐fat diet. These findings corroborated the previous beneficial effect of Kefir and brought new insights into its beneficial effect against deteriorated spermatogenesis in obese adult rats.

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Association Between Body Mass Index and Male Sperm Apoptosis and Apoptosis-Related Factors

Cited by 14 publications

References 35 publications

The effects of nutritional level and body condition score on cytokines in seminal plasma of beef bulls

The effects of nutritional level and body condition score on cytokines in seminal plasma of beef bulls

Prevalence of abnormal semen parameter among the male partner of infertile couple and factors associated with abnormal semen parameter

Kefir milk consumption decreases sperm alterations due to the high‐fat diet in adult male rats

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