Association between Body Mass Index and Prevalence of Asthma in Korean Adults

Kang, Min; Sohn, Seok-Joon; Shin, Min‐Ho

doi:10.4068/cmj.2020.56.1.62

Cited by 8 publications

(7 citation statements)

References 44 publications

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“…For example, underweight is a risk factor for vertebral fracture in men but not in women [34,35], and vertebral fracture can in turn increases the risk of dementia [36]. In addition, studies have highlighted the fact that underweight favors the occurrence of asthma in older men and not in older women [37,38], while asthma in middle and late life increases the risk of developing dementia [39]. Furthermore, preliminary research has shown that the negative effects of underweight on physical mobility limitation are more pronounced in middle-aged and older men than in their female counterparts [40], and midlife function limitations positively predict the occurrence of dementia [41].…”

Section: Interpretation Of Findingsmentioning

confidence: 99%

Sex-Differential Associations Between Body Mass Index and the Incidence of Dementia

Jacob

Smıth

Koyanagi

et al. 2022

JAD

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Background: Little is known about the sex differences in the association between body mass index (BMI) and dementia in late life. Objective: Therefore, this retrospective cohort study aimed to analyze associations between BMI and dementia in older women and men separately in general practices in Germany. Methods: This study included patients followed in one of 832 general practices in Germany between 2006 and 2019 (index date: first visit date). Study variables included dementia (dependent variable), BMI (independent variable), age, sex, and comorbidities (control variables). Kaplan-Meier curves and adjusted Cox regression analyses were conducted to analyze associations between BMI and the 10-year incidence of dementia in women and men, separately. Results: There were 296,767 patients included in this study (mean [standard deviation] age 70.2 [5.9] years; 54.3% women). The proportion of underweight, normal weight, overweight, and obesity was 0.9%, 25.5%, 41.5%, and 32.1%, respectively. The 10-year incidence of dementia significantly decreased with increasing BMI, from 11.5% in women with underweight to 9.1% in those with obesity (log-rank p < 0.001). Respective figures in men were 12.0% and 8.2% (log-rank p < 0.001). In women, only overweight (versus normal weight) was significantly associated with dementia (HR = 0.93, 95% CI = 0.88–0.97). In contrast, in men, the only BMI category significantly associated with the incidence of dementia was underweight (HR = 1.58, 95% CI = 1.11–2.25). Conclusion: In this study conducted in Germany, overweight was negatively associated with dementia in women, whereas there was a positive underweight-dementia relationship in men. More data are needed to confirm or refute these findings in other settings.

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Section: Interpretation Of Findingsmentioning

confidence: 99%

Sex-Differential Associations Between Body Mass Index and the Incidence of Dementia

Jacob

Smıth

Koyanagi

et al. 2022

JAD

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“…По данным отчета, представленного Всемирной инициативой по борьбе с бронхиальной астмой (Global Initiative for Asthma -GINA), повышенный индекс массы тела (ИМТ) является фактором риска развития, персистенции и тяжести симптомов БА [1]. Подтверждена тесная взаимосвязь между ожирением (ИМТ≥30 кг/м 2 ) и формированием БА [7]. В работе F. Huang и соавт.…”

Section: эпидемиология бронхиальной астмы и ожиренияunclassified

The pathophysiological role of adipokines in the development of bronchial asthma combined with obesity

Kytikovа

Юрьевна²,

Аntonyuk

et al. 2021

Terapevticheskii arkhiv

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The combined course of bronchial asthma (BA) and obesity is one of the urgent medical and social problems that requires a comprehensive and careful study in connection with a decrease in the quality of life of such patients, an increase in the frequency, duration of hospitalization and a high economic burden for the state as a whole. The relationship between BA and obesity is now confirmed by numerous studies, at the same time, despite the variability of the proposed mechanisms of pathogenetic effects of obesity on asthma, metabolic aspects of the relationship of these diseases need further study. Adipose tissue hormones are responsible for the energy homeostasis of the body therefore, excessive accumulation of adipose tissue is accompanied by the development of an imbalance in metabolic processes in various organs and tissues. Due to the emergence of new scientific data on the role and function of adipokines in the body, metabolic effects of adipokines are considered in the focus of their pathophysiological association with obesity and asthma. This literary review highlights the current understanding of the role of metabolic effects of the most studied adipokines (resistin, retinol-binding protein, leptin and adiponectin) in the development of obesity and BA. Gender and age-dependent features of adipokine levels in BA and obesity are described. Data on the confirmed role of adiponectin and leptin in the progression of BA combined with obesity are presented. It has been shown that the role of resistin and retinol-binding protein in the development of BA combined with obesity has not been studied. It is demonstrated that further study of metabolic activity of adipokines in BA is an actual and perspective direction of researches which will allow to develop new diagnostic and therapeutic strategies in patients with BA with obesity.

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“…Furthermore, serum albumin serves as an established clinical indicator for malnutrition ( 21 ). Asthmatic persons frequently experience malnutrition, which adversely affects their quality of life, exacerbation risk, duration of hospitalization, and overall healthcare costs ( 22 , 23 ).…”

Section: Introductionmentioning

confidence: 99%

Association between protein intake, serum albumin and blood eosinophil in US asthmatic adults

Wen,

Xia,

et al. 2024

Front. Immunol.

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BackgroundPresently, numerous studies have indicated that protein consumption and levels of blood albumin serve as important biomarkers for a range of respiratory illnesses. However, there have been few investigations into the correlation between protein consumption, serum albumin, and asthma.MethodsOur analysis incorporated 2509 asthmatics from the 2011–2018 NHANES dataset. The investigation employed three linear regression models and XGBoost model to investigate the potential link between protein intake, serum albumin levels, and blood eosinophil counts (BEOC) in patients with asthma. The trend test, generalized additive model (GAM), and threshold effect model were utilized to validate this correlation. As well, we undertook stratified analyses to look at the correlation of serum albumin with BEOC among distinct populations.ResultsIn the univariable regression model, which did not account for any covariates, we observed a positive correlation between protein intake and BEOC. However, univariable and multivariable regression analyses all suggested a negative connection of serum albumin with BEOC in asthma populations. In Model C, which took into account all possible factors, BEOC dropped by 2.82 cells/uL for every unit increase in serum albumin (g/L). Additionally, the GAM and threshold effect model validated that serum albumin and BEOC showed an inverted U-shaped correlation.ConclusionOur investigation discovered there was no independent link between asthmatics’ protein intake and BEOC. However, we observed an inverted U-shaped relationship between serum albumin levels and BEOC, suggesting a possible relationship between the overall nutritional status of asthmatics and immune system changes. Our findings provide new directions for future research in the field of asthma management and therapy.

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Association between Body Mass Index and Prevalence of Asthma in Korean Adults

Cited by 8 publications

References 44 publications

Sex-Differential Associations Between Body Mass Index and the Incidence of Dementia

Sex-Differential Associations Between Body Mass Index and the Incidence of Dementia

The pathophysiological role of adipokines in the development of bronchial asthma combined with obesity

Association between protein intake, serum albumin and blood eosinophil in US asthmatic adults

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