Association between bronchopulmonary dysplasia and <scp>MBL2</scp> and <scp>IL1‐RN</scp> polymorphisms

Çakmak, Bülent; Çalkavur, Şebnem; Özkınay, Ferda; Köroğlu, Özge Altun; Önay, Hüseyin; Itirli, Gulcin; Karaca, Emin; Yalaz, Mehmet; Akısü, Mete; Kültürsay, Nilgün

doi:10.1111/j.1442-200x.2012.03714.x

Cited by 20 publications

(7 citation statements)

References 33 publications

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“…The IL-1 family of proinflammatory cytokines, particularly an imbalance of IL-1 and IL-1 receptor antagonist (IL-1RA) protein, has previously been implicated in BPD pathogenesis (20). IL-1RN polymorphisms have been associated with increased risk of BPD (7). IL-1RA and IL-1␤ proteins have been shown to be increased at DOL 1-3 in tracheal aspirate supernatants from patients who will develop BPD (7).…”

Section: L53mentioning

confidence: 99%

“…IL-1RN polymorphisms have been associated with increased risk of BPD (7). IL-1RA and IL-1␤ proteins have been shown to be increased at DOL 1-3 in tracheal aspirate supernatants from patients who will develop BPD (7). Activated alveolar macrophages have been shown to be a source of IL-1RA (18), and while we cannot sample the alveolar space, we hypothesize that DP and SP tracheal monocytes resemble other pulmonary monocytes/ macrophages as an important source of IL-1RA.…”

Section: L53mentioning

confidence: 99%

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Infants with evolving bronchopulmonary dysplasia demonstrate monocyte-specific expression of IL-1 in tracheal aspirates

Eldredge

Creasy²,

Presnell³

et al. 2019

American Journal of Physiology-Lung Cellular and Molecular Phys

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Bronchopulmonary dysplasia (BPD) remains a devastating consequence of prematurity. Repeated inflammatory insults worsen lung injury, but there are no predictors for BPD-related respiratory outcomes or targeted therapies. We sought to understand inflammatory mechanisms in evolving BPD through molecular characterization of monocytes in tracheal aspirates from infants at risk for developing BPD. We performed flow cytometry targeting myeloid cell populations on prospectively collected tracheal aspirates from intubated patients born before 29 wk of gestation and <30 days old. We identified CD14+CD16+ (double-positive) and CD14+CD16− (single-positive) monocytes and characterized their gene expression profiles by RNA sequencing and quantitative PCR. We further analyzed differential gene expression between time points to evaluate changes in monocyte function over the first weeks of life. Expression of IL-1A, IL-1B, and IL-1 receptor antagonist mRNA was increased in monocytes collected at day of life ( DOL) 7, DOL 14, and DOL 28 compared with those collected at DOL 3. This study suggests that early changes in monocyte-specific IL-1 cytokine pathways may be associated with evolving BPD.

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Section: L53mentioning

confidence: 99%

Section: L53mentioning

confidence: 99%

Infants with evolving bronchopulmonary dysplasia demonstrate monocyte-specific expression of IL-1 in tracheal aspirates

Eldredge

Creasy²,

Presnell³

et al. 2019

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…explored the connection between BPD and IL-1RN polymorphisms. Their research showed that IL-1RN 2/2 genotype increases the risk of BPD and of IL-1RN 1/1 genotype has protective character [ 23 ]. In our research we did not prove any influence of this polymorphism on BPD risk.…”

Section: Discussionmentioning

confidence: 99%

The significance of IL-1β +3953C>T, IL-6 -174G>C and -596G>A, TNF-α -308G>A gene polymorphisms and 86 bp variable number tandem repeat polymorphism of IL-1RN in bronchopulmonary dysplasia in infants born before 32 weeks of gestation

Szpecht

Gadzinowski

Nowak

et al. 2017

cejoi

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IntroductionBronchopulmonary dysplasia (BPD) is a chronic lung disease that affects primarily preterm infants. Genetic factors are also taken into consideration in the pathogenesis of BPD. Genetic predispositions to higher production of inflammation mediators seem to be crucial. Material and methodsThe aim of this study was to evaluate the possible relationship between polymorphisms: interleukin-1β +3953 C>T, interleukin-6 -174 G>C and -596 G>A, tumour necrosis factor -308 G>A and interleukin-1RN VNTR 86bp and the occurrence of BPD in a population of 100 preterm infants born from singleton pregnancy, before 32+0 weeks of gestation, exposed to antenatal steroids therapy, and without congenital abnormalities. ResultsIn the study population BPD was diagnosed in 36 (36%) newborns. Among the studied polymorphisms we found the higher prevalence for BPD developing of the following genotypes: 1/2 (OR 1.842 [0.673-5.025] and 2/2 IL-1RN (OR 1.75 [0.418-6.908] 86bpVNTR; GC (2.222 [0.658-8.706]) and CC IL-6 -174G>C (1.6 [0.315-8.314]) and GA (2.753 [0.828-10.64]) and AA (1.5 [0.275-8.067] IL-6 -596G>A), GA 1.509 (0.515-4.301) TNF-α -308G>A. However, these finding were not statistically significant.ConclusionsGenetic factors are undeniably involved in the pathogenesis of BPD. In the times of individualised therapy finding genes responsible for BPD might allow the development of new treatment strategies. A new way of specific therapy could ensure the reduction of complications connected with BPD and treatment costs.

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“… 15 BPD was classified into three groups in terms of BPD severity depending on the duration and level of supplemental oxygen and mechanical ventilatory support at 36 weeks postmenstrual age. 16 ROP was classified according to the International Classification of Retinopathy of Prematurity. 17 …”

Section: Methodsmentioning

confidence: 99%

Mannose-binding lectin gene polymorphism and its effect on short term outcomes in preterm infants

Doğan

Özkan

Köksal

et al. 2020

Jornal de Pediatria

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Association between bronchopulmonary dysplasia and MBL2 and IL1‐RN polymorphisms

Abstract: MBL and IL 1 RN polymorphisms are closely related to low birthweight and increase the risk of neonatal sepsis and BPD development in preterm infants.

Cited by 20 publications

References 33 publications

Infants with evolving bronchopulmonary dysplasia demonstrate monocyte-specific expression of IL-1 in tracheal aspirates

Infants with evolving bronchopulmonary dysplasia demonstrate monocyte-specific expression of IL-1 in tracheal aspirates

The significance of IL-1β +3953C>T, IL-6 -174G>C and -596G>A, TNF-α -308G>A gene polymorphisms and 86 bp variable number tandem repeat polymorphism of IL-1RN in bronchopulmonary dysplasia in infants born before 32 weeks of gestation

Mannose-binding lectin gene polymorphism and its effect on short term outcomes in preterm infants

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