Association between C reactive protein and all-cause mortality in the ELSA-Brasil cohort

Maluf, Chams Bicalho; Barreto, Sandhi Maria; Giatti, Luana; Ribeiro, Antônio Luiz Pinho; Vidigal, Pedro Guatimosim; Azevedo, Douglas R. M.; Griep, Rosane Härter; Matos, Sheila Maria Alvim; Ji, Chen; Cappuccio, Francesco P.; Miller, Michelle A.

doi:10.1136/jech-2019-213289

Cited by 28 publications

(22 citation statements)

References 40 publications

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“…A study using the China Longitudinal Study of Health and Retirement (CHARLS) showed that plasma CRP was a predictor of all-cause mortality in the middle-aged and elderly population in China ( 19 ). A cohort study in Brazil also reached the same conclusion ( 20 ). Meta-analysis showed that CRP levels were associated with all-cause mortality in patients with type 2 diabetes and the risk of cardiovascular mortality was higher ( 21 ).…”

Section: Introductionsupporting

confidence: 58%

Association of Serum 25(OH)D, Cadmium, CRP With All-Cause, Cause-Specific Mortality: A Prospective Cohort Study

et al. 2022

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IntroductionTo explore the relationship between serum 25(OH)D, cadmium, and CRP with all-cause mortality among people in diabetic and non-diabetic.MethodsThis study used data from the NHANES (2001–2010). Cox regression was used to analyze the relationship between Serum 25(OH)D, cadmium, CRP, and all-cause, cause-specific mortality. We used restricted cubic splines to explore the dose-response relationship between serum 25(OH)D, cadmium, CRP, and all-cause mortality.ResultsDuring a mean follow-up of 9.1 years, the study included 20,221 participants, 2,945 people with diabetes, and 17,276 people without diabetes. Compared with serum 25(OH)D deficiency group in diabetic patients, the sufficient serum 25(OH)D group was associated with lower all-cause mortality (HR = 0.41, 95%CI 0.28-0.60, P < 0.001) and cardiovascular mortality (HR = 0.46, 95%CI 0.22–0.95, P = 0.04). Compared with the low cadmium group, the high cadmium group was associated with higher all-cause mortality (HR = 1.49, 95%CI 1.06–2.09, P = 0.02). Compared with the low CRP group, the high CRP group was associated with higher all-cause mortality (HR = 1.65, 95%CI 1.24–2.19, P = 0.001) and cancer mortality (HR = 3.25, 95%CI 1.82–5.80, P < 0.001). Restricted cubic splines analysis showed a significant nonlinear association between serum 25(OH)D (P-nonlinearity P < 0.001), cadmium (P-nonlinearity = 0.002), CRP (P-nonlinearity = 0.003), and HR for all-cause mortality risk in diabetic patients. The results were similar among non-diabetic patients, but with different levels of risk. Sensitivity analysis and subgroup analysis presented the results of population studies with different follow-up times, different genders and ages.ConclusionsIn diabetic patients, serum 25(OH)D, cadmium, and CRP were related to all-cause mortality; serum 25(OH)D was related to cardiovascular mortality; CRP was related to cancer mortality. The results were similar among non-diabetic patients, but with different levels of risk.

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Section: Introductionsupporting

confidence: 58%

Association of Serum 25(OH)D, Cadmium, CRP With All-Cause, Cause-Specific Mortality: A Prospective Cohort Study

et al. 2022

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“…Inflammation can lead to abnormal bone marrow function, resulting in poor efficiency of red blood cell production, and also affects RBC membrane permeability, which causes reticulocytes to enter the peripheral blood circulation, and increases the proportion of immature RBC, leading to an increase in RDW [ 26 ]. Inflammatory markers are associated with mortality and major adverse CV events [ 27 , 28 ]. Therefore, RDW may be used as an indicator of mortality prediction.…”

Section: Discussionmentioning

confidence: 99%

“…This study lacked the adjustment of some unmeasured confounding factors, such as iron, folate, vitamin B12 and other nutritional information. Fifthly, this study did not collect information of inflammatory biomarkers such as C-reactive protein [ 27 ], procalcitonin [ 45 ] or interleukin-6 [ 28 ], as these biomarkers were not checked in most of our study subjects. Finally, this study only discussed baseline RDW on admission, and did not include subsequent changes in RDW for analysis.…”

Section: Discussionmentioning

confidence: 99%

Red Cell Distribution Width and Mortality in Patients Undergoing Percutaneous Coronary Intervention

et al. 2021

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Red cell distribution width (RDW) can effectively predict prognosis in coronary artery disease (CAD) patients following percutaneous coronary intervention (PCI). There is currently no relevant research to demonstrate a linear or non-linear association between RDW and mortality. This is a multi-center, retrospective cohort study, with data collected from 2006 to 2017. Source data included electronic medical records of the Integrated Medical Database of National Taiwan University Hospital, and health insurance claims from the National Health Insurance Administration. Patients were stratified into five groups according to RDW values (13.4%, 14.1%, 14.8%, and 15.9%). Multivariable logistic and Cox regression analyses were used to determine 1-year all-cause and cardiovascular (CV) mortalities. Data of 10,669 patients were analyzed and those with the lowest RDW (≤13.3%) served as the reference group. The adjusted odds ratios (ORs) of 1-year all-cause mortality from the second to fifth RDW group were 1.386, 1.589, 2.090, and 3.192, respectively (p for trend < 0.001). The adjusted ORs of 1-year CV mortality were 1.555, 1.585, 1.623, and 2.850, respectively (p for trend = 0.015). The adjusted hazard ratios (HRs) of 1-year all-cause mortality were 1.394, 1.592, 2.003, and 2.689, respectively (p for trend = 0.006). The adjusted HRs of 1-year CV mortality were 1.533, 1.568, 1.609, and 2.710, respectively (p for trend = 0.015). RDW was an independent predicting factor and had a linear relationship with the 1-year all-cause and CV mortalities in patients undergoing PCI. Thus, RDW may be a clinically useful parameter to predict the mortality in those patients.

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“…Недавно опубликованные результаты бразильского исследования выявили достоверную связь вчСРБ со смертностью от всех причин в многомерной модели [14].…”

Section: Discussionunclassified

Association of high-sensitivity C-reactive protein with fatal and non-fatal cardiovascular events in working-age people: data from the ESSE-RF study

Евстифеева¹,

А²,

Куценко

et al. 2021

Russ J Cardiol

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Aim. To study the relationship of different levels of high-sensitivity C-reactive protein (hs-CRP) with cardiovascular events and assess its contribution to the development of outcomes in Russian regions.Material and methods. The work used the data from the multicenter study ESSE-RF — a representative sample of male and female population aged 25-64 years. All participants signed informed consent. The study included 10421 people (women, 6399 (61,4%)). The cohort was followed up from 2012 to 2019 (median follow-up period, 5,5 years). A hard endpoint (cardiovascular mortality and nonfatal myocardial infarction (MI)) was determined in 187 people, while a soft endpoint (nonfatal MI, stroke, revascularization, heart failure progression and cardiovascular mortality) — in 319 people.Results. The results showed that hs-CRP is significantly associated with the main risk factors (with the exception of low-density lipoproteins). At the same time, it was found that optimal hs-CRP level for predicting the risk of cardiovascular events (CVE) in Russian population is significantly lower than 3 mg/L, but higher than 1 mg/L (1,54/1,89 mg/dL for men and women, respectively). Adding hs-CRP to sex and age significantly improved risk prediction (AUC, 79,7; 95% CI, 77,8-81,7). At the same time, adding a wide list of confounders to hs-CRP, sex and age does not improve the model’s predictive value (AUC, 79,7; 78,2-82,1).Conclusion. This study for the first time showed a significant independent contribution of hs-CRP to CVEs development in the Russian population, and the addition of hs-CRP to sex and age significantly increased the predictive value of model.

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Association between C reactive protein and all-cause mortality in the ELSA-Brasil cohort

Cited by 28 publications

References 40 publications

Association of Serum 25(OH)D, Cadmium, CRP With All-Cause, Cause-Specific Mortality: A Prospective Cohort Study

Association of Serum 25(OH)D, Cadmium, CRP With All-Cause, Cause-Specific Mortality: A Prospective Cohort Study

Red Cell Distribution Width and Mortality in Patients Undergoing Percutaneous Coronary Intervention

Association of high-sensitivity C-reactive protein with fatal and non-fatal cardiovascular events in working-age people: data from the ESSE-RF study

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