Association between C-reactive protein, pro-oxidant-antioxidant balance and traditional cardiovascular risk factors in an Iranian population

Razavi, Akramosadat; Baghshani, Mohammad Reza; Rahsepar, Amir Ali; Andalibi, Mohammad Sobhan Sheikh; Parizadeh, Seyed Mostafa; Tavallaie, Shima; Mousavi, Somayeh; Ghayour‐Mobarhan, Majid; Ferns, Gordon A.

doi:10.1258/acb.2012.012104

Cited by 16 publications

(9 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Not only has CRP been associated with the chain of events occurring at the endothelium within the atherosclerotic process [54, 55], but it has also been linked with a direct, independent association with future cardiovascular events in several great-scale epidemiologic reports [27, 56, 57], as well as with other disorders of metabolic origin, both in adult and pediatric populations [58, 59]. …”

Section: Cardiovascular Risk Factors: Classic Versus Novel (Table 1)mentioning

confidence: 99%

C-Reactive Protein: Clinical and Epidemiological Perspectives

Salazar

Martínez

Chávez-Castillo

et al. 2014

Cardiology Research and Practice

View full text Add to dashboard Cite

An important etiopathogenic component of cardiovascular disease is atherosclerosis, with inflammation being an essential event in the pathophysiology of all clinical pictures it comprises. In recent years, several molecules implicated in this process have been studied in order to assess cardiovascular risk in both primary and secondary prevention. C-reactive protein is a plasmatic protein of the pentraxin family and an acute phase reactant, very useful as a general inflammation marker. Currently, it is one of the most profoundly researched molecules in the cardiovascular field, yet its clinical applicability regarding cardiovascular risk remains an object of discussion, considered by some as a simple marker and by others as a true risk factor. In this sense, numerous studies propose its utilization as a predictor of cardiovascular risk through the use of high-sensitivity quantification methods for the detection of values <1 mg/L, following strict international guidelines. Increasing interest in these clinical findings has led to the creation of modified score systems including C-reactive protein concentrations, in order to enhance risk scores commonly used in clinical practice and offer improved care to patients with cardiovascular disease, which remains the first cause of mortality at the worldwide, national, and regional scenarios.

show abstract

Section: Cardiovascular Risk Factors: Classic Versus Novel (Table 1)mentioning

confidence: 99%

C-Reactive Protein: Clinical and Epidemiological Perspectives

Salazar

Martínez

Chávez-Castillo

et al. 2014

Cardiology Research and Practice

View full text Add to dashboard Cite

show abstract

“…In addition, several inflammatory indicators [such as homocysteine, fibrinogen, white blood cell count and the C-reactive protein (CRP)] are highly correlated with the degree of OC (Zaldivar et al 2006;Darvall et al 2007;Wee et al 2008;Uysal et al 2014). Studies have shown that an elevated white blood cell count and plasma CRP levels are associated with the development of CVD (Twig et al 2012;Razavi et al 2013). However, a large body of evidence has established fibrinogen as independent risk factor for CVD, and as an important mediator through which traditional risk factors, such as low-density lipoprotein, exert their effects (Clark et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Fruit vinegars attenuate cardiac injury via anti-inflammatory and anti-adiposity actions in high-fat diet-induced obese rats

Bounihi

Bitam

Bouazza

et al. 2016

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…5 ROS have been suggested as a cause of death for many cells in different pathological states including various models of liver, renal and cardiac diseases. 6 Also, clinical and experimental studies have shown that disturbing oxidant-antioxidant balance system is involved in the pathogenesis of chronic diseases such as cancer, 7 coronary heart disease, diabetes, liver injury and kidney injury. [8][9][10] Antioxidant and antioxidative enzyme activities reduce due to GM or increase of lipid peroxidation products.…”

Section: Introductionmentioning

confidence: 99%

Serum paraoxonase 1 status and its association with atherogenic indexes in gentamicin-induced nephrotoxicity in rats treated with coenzyme Q10

et al. 2013

View full text Add to dashboard Cite

Coenzyme Q10 is a natural antioxidant and scavenger of free radicals. In the present study, we examined the effect of coenzyme Q10 on paraoxonase 1 (PON1) activity, lipid profile, atherogenic indexes and relationship of PON 1 activity by high-density lipoprotein (HDL) and atherogenic indexes in gentamicin (GM)-induced nephrotoxicity rats. Thirty Sprague-Dawley rats were divided into three groups to receive saline; GM, 100 mg/kg/d; and GM plus coenzyme Q10 by 15 mg/kg i.p daily, respectively. After 12 days, animals were anaesthetized, blood samples were also collected before killing to measure the levels of triglyceride (TG), cholesterol (C), low-density lipoprotein (LDL), very low density lipoprotein (VLDL), HDL, atherogenic indexes and the activities of PON1 of all groups were analyzed. Data were analyzed by non-parametric Mann-Whitney test (using SPSS 13 software). Coenzyme Q10 significantly decreased TG, C, LDL, VLDL, atherogenic index, atherogenic coefficient and cardiac risk ratio. HDL level and PON1 activity were significantly increased when treated with coenzyme Q10. Also, the activity of PON 1 correlated positively with HDL and negatively with atherogenic coefficient, cardiac risk ratio 1 and cardiac risk ratio 2. This study showed that coenzyme Q10 exerts beneficial effects on PON1 activity, lipid profile, atherogenic index and correlation of PON 1 activity with HDL and atherogenic index in GM -induced nephrotoxicity rats.

show abstract

Association between C-reactive protein, pro-oxidant-antioxidant balance and traditional cardiovascular risk factors in an Iranian population

Cited by 16 publications

References 57 publications

C-Reactive Protein: Clinical and Epidemiological Perspectives

C-Reactive Protein: Clinical and Epidemiological Perspectives

Fruit vinegars attenuate cardiac injury via anti-inflammatory and anti-adiposity actions in high-fat diet-induced obese rats

Serum paraoxonase 1 status and its association with atherogenic indexes in gentamicin-induced nephrotoxicity in rats treated with coenzyme Q10

Contact Info

Product

Resources

About