2023
DOI: 10.21203/rs.3.rs-2400883/v1
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Association between cardiopulmonary bypass time and clinical outcomes among patients with acute respiratory distress syndrome after cardiac surgery

Abstract: Background:Cardiopulmonary bypass (CPB) can lead to lung injury and even acute respiratory distress syndrome (ARDS) through triggering systemic inflammatory response. The objective of this study was to investigate the impact of CPB time on clinical outcomes in patients with ARDS after cardiac surgery. Methods:Totally, patients with ARDS after cardiac surgery in Beijing Anzhen Hospital from January 2005 to December 2015 were retrospectively included and were further divided into three categories according to CP… Show more

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Cited by 3 publications
(3 citation statements)
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“…13 Hu et al depicted that optimal cut-off duration of CPB was less than 160 min for ICU and inhospital mortality. 14 Nadeem et al illustrated that CPB time duration acts to affect clinical outcomes adversely and is associated with prolonged postoperative mechanical ventilation. 15 Therefore, with the intention of finding the optimal limit of safe CPB duration, we conducted this retrospective observational study of 202 patients; we divided the patients into groups according to the duration of CPB and observed intraoperative and postoperative recovery parameters in each group.…”
Section: Discussionmentioning
confidence: 99%
“…13 Hu et al depicted that optimal cut-off duration of CPB was less than 160 min for ICU and inhospital mortality. 14 Nadeem et al illustrated that CPB time duration acts to affect clinical outcomes adversely and is associated with prolonged postoperative mechanical ventilation. 15 Therefore, with the intention of finding the optimal limit of safe CPB duration, we conducted this retrospective observational study of 202 patients; we divided the patients into groups according to the duration of CPB and observed intraoperative and postoperative recovery parameters in each group.…”
Section: Discussionmentioning
confidence: 99%
“…10 The higher mortality in the haemofiltration group can be attributed to longer CPB and AXC durations. [11][12][13] Prolonged CPB times could predict postoperative clinical events, in particular mortality. 14 In our study, the postoperative benefits of using haemofiltration during CPB were earlier tracheal extubation and shorter hospital stay (Table 2).…”
Section: Discussionmentioning
confidence: 99%
“…The development of ARDS is likely multifactorial, and the presence of preexisting cardiac dysfunction theoretically aggravates the degree of pulmonary edema in patients who develop ARDS. 17 An accurate diagnosis of ARDS is critical because optimal treatment strategieswhich include the use of high PEEP, low tidal volume (V T ) ventilation, and permissive hypercapnia 18 -may conflict with treatment for cardiac surgical patients, specific patients with poor RV function, and patients with recent sternotomy. Furthermore, the increased risk of ARDS after cardiac surgery has traditionally been associated with the use of cardiopulmonary bypass (CPB), the need for blood product transfusions, large volume shifts, mechanical ventilation, and direct surgical insult.…”
Section: Diagnosis After Surgerymentioning
confidence: 99%