Association between cerebral microbleeds and inflammatory biomarkers in patients with ischemic stroke

Diker, Sevda; Gelener, Pınar; Eker, Amber; Kaymakamzade, Bahar; Mut, Senem Ertugrul; Erem, Aysegul; Balyemez, Uğurcan

doi:10.1186/s41983-022-00478-6

Cited by 2 publications

(1 citation statement)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Epidemiological studies have proven that cholesterol is associated with stroke and insu cient cerebral circulation due to high cholesterol is implicated in the etiology of stroke (Larsson et al, 2012;Colin-Castelan and Zaina, 2019). A study has unequivocally unveiled that unhealthy HCD patterns can evoke basal systemic in ammation (Cai and Liu, 2012), a typical pathological stroke feature (Diker et al, 2022). Notably, obese individuals were more susceptible to PM 2.5 (Noh et al, 2019) and HCD intake and PM 2.5 exposure increased the risk of stroke (Larsson et al, 2012;Qiu et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Combined exposure to high-cholesterol diet and PM 2.5 : Brain injury and regulatory mechanism of HIF-1α in female mice

Chen

Bai

et al. 2023

Preprint

View full text Add to dashboard Cite

High-cholesterol diet (HCD) and fine particulate matter (PM2.5) are related to stroke. The comprehensive influence of two factors on stroke is not well known, especially for females. In this study, we investigated brain injury and behavioral changes in female mice exposed to HCD plus PM2.5 for three months and six months, respectively. We measured gene expression of some factors related to stroke and the blood-brain barrier (BBB) in different groups of mice and further explored molecular mechanisms of epigenetic regulation of hypoxia-inducible factor-1α (HIF-1α). The results showed that HCD and PM2.5 co-exposure altered brain-body weight ratio, induced brain pathology damage and behavioral abnormality and elevated inflammatory markers (IL-6 and TNF-α) in mice relative to exposure to PM2.5 or HCD alone. Six-month exposure caused more severe brain damage than that three-month exposure. Co-exposure significantly changed the expressions of HIF-1α and the key genes (VEGF/COX-2/MMP-9/ZO-1/Occludin) in the HIF-1α signaling pathway in the brains of mice compared to the single exposure. Interestingly, HIF-1α was epigenetic regulated by histone deacetylase 4 (HDAC4) and histone 3 lysine 9 acetylation (H3K9ac) by chromatin immunoprecipitation (ChIP) assay. It suggests that the HIF-1α pathway exerts a crucial regulatory role in brain injury and behavioral abnormality in female mice after six-month exposure to HCD plus PM2.5, which are potential mechanisms for HCD and PM2.5-triggering stroke risk in female individuals.

show abstract

Section: Introductionmentioning

confidence: 99%

Combined exposure to high-cholesterol diet and PM 2.5 : Brain injury and regulatory mechanism of HIF-1α in female mice

Chen

Bai

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Combined Exposure to High-Cholesterol Diet and PM2.5: Brain Injury and Regulatory Mechanism of HIF-1α in ApoE−/− Female Mice

Chen,

Bai

et al. 2024

Atmosphere

View full text Add to dashboard Cite

High-cholesterol diet (HCD) and fine particulate matter (PM2.5) are related to stroke. However, little is known about the combined effects of stroke, especially for females. This study investigated the brain injuries in Apolipoprotein E−/− (ApoE−/−) female mice exposed to HCD plus PM2.5 for 6 months. The protein levels of the genes related to stroke and the blood–brain barrier (BBB) in different groups of mice were measured. The molecular regulation mechanisms were explored. The results showed that HCD and PM2.5 co-exposure altered brain–body weight ratio, behavior, brain pathology, and inflammatory markers in mice relative to exposure to HCD or PM2.5 alone. Co-exposure significantly changed the expressions of HIF-1α and the key genes in its signaling pathway in the brains of mice compared to the single exposure. It suggests that the HIF-1α pathway exerts an important regulatory role in brain injury and behavioral abnormality in female mice after 6-month exposure to HCD plus PM2.5, which are potential mechanisms for HCD and PM2.5-triggering stroke in female individuals.

show abstract

Association between cerebral microbleeds and inflammatory biomarkers in patients with ischemic stroke

Cited by 2 publications

References 44 publications

Combined exposure to high-cholesterol diet and PM 2.5 : Brain injury and regulatory mechanism of HIF-1α in female mice

Combined exposure to high-cholesterol diet and PM 2.5 : Brain injury and regulatory mechanism of HIF-1α in female mice

Combined Exposure to High-Cholesterol Diet and PM2.5: Brain Injury and Regulatory Mechanism of HIF-1α in ApoE−/− Female Mice

Contact Info

Product

Resources

About