Association between childhood eczema and headaches: An analysis of 19 US population-based studies

Silverberg, Jonathan I.

doi:10.1016/j.jaci.2015.07.020

Cited by 35 publications

(33 citation statements)

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“…In addition, a casecontrol study in children with and without migraine demonstrated a higher risk of AD and other atopic diseases (19). Furthermore, several reports found a greater prevalence of headache and migraine in children with atopic disorders than their peers without atopic disorders (20), and a recent cross-sectional study of a large pediatric population demonstrated that children with eczema have higher odds (1.52) of having headaches (21). Our study revealed a statistical association between AD and migraine in adolescents, consistent with the association previously found in children.…”

Section: Discussionsupporting

confidence: 91%

Atopic Dermatitis in Israeli Adolescents from 1998 to 2013: Trends in Time and Association with Migraine

Shreberk‐Hassidim

Hassidim

Gronovich

et al. 2017

Pediatric Dermatology

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Section: Discussionsupporting

confidence: 91%

Atopic Dermatitis in Israeli Adolescents from 1998 to 2013: Trends in Time and Association with Migraine

Shreberk‐Hassidim

Hassidim

Gronovich

et al. 2017

Pediatric Dermatology

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“…Intense pruritus, high rates of sleep disturbance, stigma, social isolation, poor quality of life, and neuro-inflammation have been postulated to contribute to increased anxiety, depression, or suicidality in AD. Sleep disturbances in AD were shown to be associated with a number of poor outcomes in AD patients, including headaches, 69 shorter stature in children, 70 poor QOL in children and adults, 5,13,14,71 increased fractures and other injuries, 72 and even cardiovascular risk factors or disease in adults. 73 Fatigue and sleep disturbances may increase the risk of, or share a common mechanism with, anxiety or depression.…”

Section: Mechanismmentioning

confidence: 99%

Comorbidities and the impact of atopic dermatitis

Silverberg

2019

Annals of Allergy, Asthma & Immunology

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294

209

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Atopic dermatitis (AD) impacts all aspects of patients' quality of life and emotional well-being. Atopic dermatitis has a complex relationship with atopic comorbidities, including asthma, food allergy, and eosinophilic esophagitis. Atopic dermatitis is associated with symptoms of anxiety and depression, which are highly correlated with severity of AD signs and symptoms. Atopic dermatitis is associated with multiple cutaneous and extracutaneous infections of bacterial, mycobacterial, viral, and fungal origins. Atopic dermatitis is associated with increased cardiovascular risk factors, and potentially with cardiovascular disease and events.

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“…Histamine modulates neurogenic inflammation and nociceptive sensitization. Eczema, where histamine is fundamental for inducing allergic inflammation, is associated with increased headaches in childhood, particularly in patients with severe disease accompanied by atopy, fatigue, and sleep disturbances . Higher migraine prevalence also is found in patients with allergic rhinitis .…”

Section: Introductionmentioning

confidence: 99%

Histamine and Migraine

Yuan

Silberstein

2017

Headache

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Background Histamine is an ancient “tissue amine” preceding multicellular organisms. In the central nervous system (CNS), its fibers originate solely from the tuberomammillary nucleus and travel throughout the brain. It is mainly responsible for wakefulness, energy homeostasis, and memory consolidation. Recently, several studies suggest a potential role of histamine in migraine pathogenesis and management. Methods Narrative review of current literature regarding histamine and migraine. Results Histamine plays a crucial role in migraine pathogenesis: sustaining the neurogenic inflammation pathway. Interaction between mast cells (MC) and calcitonin‐gene related protein (CGRP) results in sensitization of trigeminal afferents and trigeminal ganglia (TG). Histamine binds with differing affinities to four different histaminergic G‐protein coupled receptors, activating protein kinases, or triggering calcium release with subsequent mode of actions. Histamine 1 receptor (H1R) and histamine 2 receptor (H2R) antagonists are frequently used for the treatment of allergy and gastric acid secretion, respectively, but their antagonism is probably ineffective for migraine. Histamine 3 receptor (H3R) and histamine 4 receptor (H4R) have a threefold higher affinity than H1R/H2R for histamine and are found almost exclusively on neurons and immune tissues, respectively. H3R acts as an autoreceptor or as a heteroreceptor, lowering the release of histamine and other neurotransmitters. This is a potential target for anti‐nociception and anti‐neurogenic inflammation. To date, several small clinical trials using low dose histamine or Nα‐methylhistamine have demonstrated migraine prophylactic efficacy, probably via H3R or other undetermined pathways. Conclusion The histamine system interacts with multiple regions in the CNS and may hypothetically modulate the migraine response. Low dose histamine may be a promising option for migraine prevention.

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Association between childhood eczema and headaches: An analysis of 19 US population-based studies

Abstract: Background-Atopic dermatitis (or eczema) is a chronic inflammatory disorder associated with sleep disturbances and quality-of-life impairment. Sleep disturbances have been shown to cause headaches in childhood. However, an association between eczema and headaches is not well established.

Cited by 35 publications

References 36 publications

Atopic Dermatitis in Israeli Adolescents from 1998 to 2013: Trends in Time and Association with Migraine

Atopic Dermatitis in Israeli Adolescents from 1998 to 2013: Trends in Time and Association with Migraine

Comorbidities and the impact of atopic dermatitis

Histamine and Migraine

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