Association Between Chlamydia pneumoniae infection and Lung Cancer: A Meta-Analysis

Abstract

Aims: To explore the correlation between Chlamydia pneumoniae infection and lung carcinoma. Methods: Databases of PubMed, Embase, Embase, Ovid, Wanfang and China National Knowledge Infrastructure (CNKI) database were investigated for eligible literatures from their establishments to February, 2019. Included studies were selected according to specific eligibility criteria. Statistical analysis were performed by RevMan 5.3 software. Results: Thirteen studies with 2553 lung carcinoma cases and 2460 controls were eligible for meta-analysis. The pooled results indicated that the C. pneumoniae infection IgA significant increased the risk of lung carcinoma (OR=3.19; 95% CI=1.96-5.19; p < 0.00001) by random effect model. And for serum IgG, the pooled OR was 2.02 ( 95% CI=1.29-3.16; p < 0.00001) by using the random effects model. The results indicated that the IgA positive rate was significantly higher in lung cancer patients than healthy controls. Conclusions: This meta-analysis revealed that C. pneumoniae infection may be a potential risk factor for lung carcinoma. However, due to its significant heterogeneity in the included studies, the consequence should be understand with caution.

Chlamydia pneumoniae infections and development of lung cancer: systematic review

“…These inflammatory mediators will cause lung tissue and DNA damage which can result in carcinogenesis. IL-8 also acts as a promoter of tumor growth for human NSCC through its angiogenic properties [ 25 ].…”

Assessment of the Association of Chlamydia e pneumoniae Infection with Lung Cancer in a Moroccan Patients’ Cohort

“…Via mis-repair or incomplete repair, the accumulation of damaged DNA can lead to mutagenesis and cell transformation (Prasad et al, 2017). On the other, side chronic C. pneumoniae infection could liberate Chlamydia l heat shock protein-60 (CHSP-60), which may act as a part of the pathogenesis of lung carcinoma (Wang et al, 2019). Furthermore, the relationship between C. pneumoniae infection and LC risk could vary when combined with environmental factors.…”