Association Between Cholesterol Plasma Levels and Craving Among Heroin Users

Lin, Shih-Hsien; Yang, Yen Kuang; Lee, Sheng-Yu; Hsieh, Pei-Chun; Chen, Po See; Lu, Ru‐Band; Chen, Kao Chin

doi:10.1097/adm.0b013e318262a9a1

Cited by 18 publications

(12 citation statements)

References 38 publications

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“…This association was independent of the effect of LDL cholesterol, which has been found to be associated with the craving for heroin [29]. Our findings confirmed that the plasma oxytocin level is not only associated with physical dependence and withdrawal in animal models [1] but also with craving for heroin among humans.…”

Section: Discussionsupporting

confidence: 77%

“…The CS has an acceptable internal consistency (Cronbach alpha = 0.90) based on a large-sample study ( n = 958) performed in Taiwan [46]. The validity of this instrument was supported by our previous study [29]. …”

Section: Methodsmentioning

confidence: 53%

“…The concentrations of high-density lipoprotein cholesterol and LDL cholesterol were measured enzymatically after dextran sulfate-magnesium precipitation: high-density lipoprotein cholesterol, c.v. 2.3–3.9%; LDL cholesterol, c.v. 1.4–2.2%. Owing to the findings of our previous study [29], LDL cholesterol was used as a controlling variable.…”

Section: Methodsmentioning

confidence: 99%

“…Meanwhile, the plasma lipid level may be correlated with addiction [28]. The low-density lipoprotein (LDL) cholesterol level was found to be negatively associated with heroin craving [29], and cholesterol may alter the function of oxytocin [30, 31]. Therefore, we also controlled the potential effect of cholesterol in this study.…”

Section: Introductionmentioning

confidence: 99%

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The Association between the Level of Plasma Oxytocin and Craving among Former Heroin Users

et al. 2018

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Background: Animal studies have demonstrated that oxytocin can influence addiction behaviors and might interact with the dopaminergic system, which is a key component of addiction behaviors. However, related evidence from clinical studies is scarce. The aim of our study was to explore the relationship between plasma oxytocin level and heroin craving among patients receiving methadone maintenance treatment, and to ascertain whether this relationship is moderated by novelty-seeking. Methods: The study was conducted in a methadone maintenance therapy clinic of a medical center in Taiwan. Seventy-seven patients with heroin addiction were enrolled. Plasma oxytocin was measured using an ELISA kit. Craving was assessed using an established instrument, the Chinese Craving Scale. Results: A significant negative association was found between the plasma oxytocin level and craving score, which remained robust after controlling the effects of social support and low-density lipoprotein cholesterol. An interaction between oxytocin and novelty-seeking indicated that this relationship was stronger among patients with a lower level of novelty-seeking. Conclusion: This finding may be taken into account in future studies and may provide a basis for the development of potential treatment for addiction. The effect of oxytocin for the treatment of opioid dependence might be modulated by some psychological factors.

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Section: Discussionsupporting

confidence: 77%

Section: Methodsmentioning

confidence: 53%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Association between the Level of Plasma Oxytocin and Craving among Former Heroin Users

et al. 2018

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“…To date, serum lipid is known to influence relapse of heroin use. [13] Previous research have studied the changes of serum lipid level in heroin and opium abusers. Divsalar et al [14] found that compared to the control group, heroin-dependents showed significantly higher total cholesterol (TC) levels.…”

Section: Introductionmentioning

confidence: 99%

The levels of triglyceride and total cholesterol in methamphetamine dependence

Zhang

Lv²,

Zhou³

et al. 2017

Medicine

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The serum triglyceride (TG) and total cholesterol (TC) levels have been reported altered in the traditional drug-dependence (such as marijuana and heroin). However, studies assessing the relationships among serum TC, TG, and methamphetamine (MA)-dependence have not been described well. In this study, our aim is to explore the serum TG and TC levels in large sample of MA-dependent patients. A retrospective study was conducted in 938 MA-dependent patients who were recruited between February 2, 2008 and March 11, 2013, with social characteristics and drug-dependence history (duration of MA use, routes of drug administration, and daily dose were collected). Then, the serum levels of TC, TG, glucose (GLU), body mass index (BMI), and blood pressure were measured among the participants. Meanwhile, 985 age- and gender-matched healthy people in the physical examination center were selected as control group. Compared with the control group, significant decreases of TC, TG, GLU, and BMI were observed in MA-dependent patients (P < 0.05). Besides, we found that the daily dose of MA use was associated with TC (β = −0.079, P = 0.015) and the duration of MA use was independently related to BMI (β = −0.071, P = 0.031). This study demonstrated that the levels of TC, TG, GLU, and BMI factors altered in the MA-dependent patients. In addition, there is a negative association between MA dependence and TC and BMI.

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Cardiovascular complications and related risk factors underlying opium consumption

Ebdali

Tabaee

Tabaei

2018

Journal Cellular Physiology

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Opium is considered as the second most abused addictive compound in worldwide. It seems that one of the causes for common consumption of opium in many countries is a traditional belief, even among medical personnel, through which opium might have advantageous influences on cardiovascular events and be beneficial in controlling hypertension, dyslipidemia, and diabetes. According to several investigations, it is thought that opium not only has no beneficial effects on cardiovascular events, but it might have deleterious influences on these settings. As a result, people need to be trained with regard to the adverse effects of opium on cardiovascular events. In this review, we try to go through the understanding of the effects of opium cardiovascular disorders and related complications such as blood pressure, blood sugar, lipid circumstances, and finally atherosclerosis.

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Association Between Cholesterol Plasma Levels and Craving Among Heroin Users

Abstract: Cholesterol could be associated with the cognitive aspect of craving and may be a potential marker to predict risk of drug relapse.

Cited by 18 publications

References 38 publications

The Association between the Level of Plasma Oxytocin and Craving among Former Heroin Users

The Association between the Level of Plasma Oxytocin and Craving among Former Heroin Users

The levels of triglyceride and total cholesterol in methamphetamine dependence

Cardiovascular complications and related risk factors underlying opium consumption

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