Association Between Circulating Level of CD40 Ligand and Angiographic Morphologic Features Indicating High-Burden Thrombus Formation in Patients With Acute Myocardial Infarction Undergoing Primary Coronary Intervention

Youssef, Ali A.; Chang, Li-Teh; Sheu, Jiunn‐Jye; Lee, Fan-Yen; Chua, Sarah; Yeh, Kuo-Ho; Yang, Cheng‐Hsu; Wu, Chiung‐Jen; Yip, Hon‐Kan

doi:10.1253/circj.71.1857

Cited by 21 publications

(13 citation statements)

References 24 publications

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“…Except these reports, sufficient data are not available concerning the sCD40L levels in acute ST segment elevation MI. Youssef et al [14] recently studied the relation between the circulating level of sCD40L and thrombus burden in the infarct-related artery. In the acute phase of MI, sCD40L levels were significantly higher in the high thrombus formation group compared to the low thrombus formation group.…”

Section: Discussionmentioning

confidence: 99%

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Plasma concentrations of soluble CD40 ligand in smokers with acute myocardial infarction: a pilot study

et al. 2010

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Coronary artery disease (CAD) is believed to be the single leading cause of death in both men and women in the world. Smoking is the most important risk factor for CAD. Smoking increases platelet aggregation and thrombus formation. CD40 ligand (CD40L) is a transmembrane glycoprotein derived from activated platelets. It participates in thrombus formation during the acute phase of acute myocardial infarction (MI). Elevation of CD40L identifies the patients who are at highest risk for cardiac events and who are likely to benefit from treatment with the glycoprotein IIb/IIIa (GPIIb/IIIa) receptor antagonists. The purpose of this study was to evaluate levels of CD40L in smokers with acute MI. Fifty-seven patients with acute MI were enrolled in this study. Thirty-one smokers were compared with 26 non-smokers. Soluble CD40L level in the plasma was determined by a standard enzyme-linked immunosorbent assay. Circulating levels of CD40L were higher in the smokers’ group. Smokers with acute MI may have increased risk for thrombotic complications during acute MI, and optimal antiaggregant therapy should be administered.

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Section: Discussionmentioning

confidence: 99%

“…CD40L levels are also elevated in patients with acute MI [11]. In addition, several studies demonstrated that the circulating level of CD40L was related to a high thrombus burden in acute MI and long-term mortality [12–14]. Cigarette smokers also have upregulation of the CD40/CD40L dyad [15].…”

Section: Introductionmentioning

confidence: 99%

Plasma concentrations of soluble CD40 ligand in smokers with acute myocardial infarction: a pilot study

et al. 2010

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“…Henn et al (6) proposed that in vivo, once platelets were strongly activated in the vascular system, CD40L would be rapidly expressed on aggregating cells and available to interact with CD40 on the neighbouring endothelial cells and on monocytes trapped in the thrombus. Furthermore, CD40L could also have a direct participation in the thrombotic process either in thrombus stabilization (7) or in its formation at the infarct-related artery (8). Several studies showed high affinity of soluble CD40L (sCD40L) and CD40L for CD40 when TNF-α receptors and integrins are expressed (7).…”

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confidence: 99%

Prognostic evaluation of soluble CD40L in acute myocardial infarction: is not fancy, is science!

2017

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“…Additionally, as compared with prior CS, the platelet activity was still persistently or more activated in patients after CS [47]. Intriguingly, our other previous studies have also displayed that the circulating level of soluble CD40 ligand (sCD40L), an index of platelet activation, was significantly higher in patients with coronary arterial Research Hon-Kan Yip obstructive syndrome undergoing coronary stenting [48][49][50]. Additionally, sCD40L was predictive of angiographic morphologic features of high-burden thrombus formation [50] that is well known to play a crucial role for procedural failure during coronary intervention and unfavorable prognostic outcome.…”

Section: Discussionmentioning

confidence: 81%

Link between Systemic and Cerebral Circulatory Levels of Microparticles and Necrosis Area of Stenotic Carotid Artery in the Patients Undergoing Carotid Stenting

Sung¹,

Tong²,

Chu³

et al. 2018

Neuropsychiatry

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Objective: We tested the hypothesis that (1) platelet-derived activated microparticles (PDAc-MPs) and endothelial-derived activated (EDAc)-MPs were significantly higher after carotid stenting (CS) than before CS in carotid artery (CA) (defined as systemic circulation) and internal jugular vein (IJV) (defined as cerebral circulation) and (2) significantly correlated with necrotic area in CA stenosis measured by virtual histology intra-vascular ultrasound (VH-IVUS) prior to CS.Methods: From September 2013 to 2016 July, a total of 92 consecutive patients undergoing CS were prospectively enrolled into the study. Blood samples for level of MPs were collected from CA and IJV prior to and 5-mintes after CS, respectively. Results:The frequency of previous ischemic stroke (IS) was 45.7% (42/92). The mean stenosis prior to CS was 88.8%. The procedural success was 100% and incidences of TIA and acute IS were 3.3% (3/92) and 4.3% (4/92), respectively. No significant correlation existed between severity of CA stenosis and circulating MPs level (p>0.5). The PDAc-MPs was significantly higher in post-CS procedure than in pre-CS procedure in both RIJV and CA (all p<0.007), whereas the EDAc-MPs was significantly higher in post-CS procedure than in pre-CS procedure in CA (p=0.003). Post-CS PDAc-MPs and EDAc-MPs as well as ratio of post-to pre-CS PDAc-MPs were moderately correlated to necrotic area of carotid plagues (all p<0.005). Conclusion:Cerebral and systemic PDAc-MPs and systemic EDAc-MPs were markedly increased in post CS than in that of prior to CS. Post-CS PDAc-MPs/EDAc-MPs and ratio of post/pre-CS PDAc-MPs were notably correlated to necrotic area of stenotic carotid plaque.

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Association Between Circulating Level of CD40 Ligand and Angiographic Morphologic Features Indicating High-Burden Thrombus Formation in Patients With Acute Myocardial Infarction Undergoing Primary Coronary Intervention

Cited by 21 publications

References 24 publications

Plasma concentrations of soluble CD40 ligand in smokers with acute myocardial infarction: a pilot study

Plasma concentrations of soluble CD40 ligand in smokers with acute myocardial infarction: a pilot study

Prognostic evaluation of soluble CD40L in acute myocardial infarction: is not fancy, is science!

Link between Systemic and Cerebral Circulatory Levels of Microparticles and Necrosis Area of Stenotic Carotid Artery in the Patients Undergoing Carotid Stenting

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