Association between circulating specific leukocyte types and blood pressure: the Atherosclerosis Risk in Communities (ARIC) study

Tian, Niu; Penman, Alan D.; Mawson, Anthony R.; Manning, R. Davis; Flessner, Michael F.

doi:10.1016/j.jash.2010.09.005

Cited by 34 publications

(31 citation statements)

References 58 publications

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“…Previous studies have suggested that there is a relation between hypertension and systemic inflammation [12]. The relationship between circulating subtype of white blood cell and hypertension has also been well documented [13,14]. In a large cohort with a long follow-up period, Tatsukawa et al [13] aimed to investigate the relationship between white blood cell count, including differential white blood cell count, and the incidence of hypertension over a 40-year period in 9,383 subjects who did not have hypertension at baseline.…”

Section: Discussionmentioning

confidence: 94%

Relation of neutrophil/lymphocyte ratio to resistant hypertension

Dağlı

Doğdu

Şenarslan³

et al. 2016

Eur Res J

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Objectives. Resistant hypertension has unfavourable effects on cardiovascular and other systems. The aim of this study was to investigate the association of neutrophil/lymphocyte (N/L) ratio and resistant hypertension. Methods. A total of 140 patients were included in the study. Ambulatory 24-hour blood pressure monitoring, transthoracic echocardiography and blood sample analyzing were performed in all patients. There were 60 patients with resistant hypertension group (mean age=55.1±9.7 years) and 80 patients with non-resistant hypertension group (mean age=56.8±14.1 years). Results. Mean neutrophil levels were significantly higher in resistant hypertension group (71.7±6.1% vs. 65.9±5.4%, p<0.001), while lymphocyte levels were significantly higher in non-resistant hypertension group (22±4.7% vs. 17.5±4. 1%, p<0.001). N/L ratio was significantly higher in resistant hypertension group (4.3±1.2 vs. 3.1±0.9, p<0.001). In multivariate analysis, diabetes mellitus (odds ratio [OR]=2.857; 95% confidence interval [CI], 1. 349-6.053; p=0.006), N/L ratio (OR=2.699; 95% CI, 1. p<0.001) and obesity (OR=3.429; 95% CI, p=0.001) were independent predictors of resistant hypertension. Conclusion. The N/L ratio, which is cheaply and easily measurable laboratory data, is independently associated with resistant hypertension.Eur Res J 2016;2(3):211-218

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Section: Discussionmentioning

confidence: 94%

Relation of neutrophil/lymphocyte ratio to resistant hypertension

Dağlı

Doğdu

Şenarslan³

et al. 2016

Eur Res J

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“…In another study, SUA was significantly and independently associated with neutrophil count (34). In a recently published study, hyperlipidemia-triggered neutrophilia was shown to promote early atherosclerosis (35 In another recent study, Tian et al (36) searched the association between circulating specific leukocyte types and blood pressure and found that blood pressure is specifically related to N and L. Kawada et al (37) showed an independent relationship between N and hypertension. In the study by Yen et al, the investigators searched the relation between hsCRP, standard CVRFs and WBC, neutrophils and monocytes.…”

Section: Discussionmentioning

confidence: 99%

The particular interactions of the traditional cardiovascular risk factors with different circulating specific leukocyte subtype counts in blood: an observational study

Kocaman

Şahinarslan²,

Kunak³

et al. 2011

Anadolu Kardiyol Derg

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Objective: The pathogenesis of atherosclerosis is multifactorial, however the impact of inflammatory cells in this process is well known. Different traditional cardiovascular risk factors (CVRFs) may have specifically different effects on leukocyte subtype. Thus, these special interactions may induce different vascular involvement forms due to the altered endothelial damage and vascular repair mechanisms. The aim of the present study was to investigate whether there is any specific relationship between the leukocyte subtypes and the traditional CVRFs and to evaluate the independency of possible relationships. Methods: The study had a cross-sectional observational design. The study population consisted of the patients who underwent coronary angiography with a suspicion of coronary artery disease (CAD) at our institution in an outpatient manner. We enrolled 677 consecutive eligible patients with CAD or normal coronary arteries (NCA) and investigated the associations of traditional CVRFs, demographic properties and biochemical parameters including fasting plasma glucose (FPG), creatinine, serum uric acid level (SUA) and lipids with total circulating inflammatory cell (WBC, leukocytes) and subtype counts including neutrophils (N), lymphocytes (L) and monocytes (M). As a dependent variable, total leukocyte count and subtypes, and neutrophil/lymphocyte ratio (N/L ratio) which has been found to being related with increased vascular risk and events were investigated in the groups determined by the presence or absence of CVRFs and CAD by the univariate analyses and then multiple linear regression analyses. Results: When we performed multiple linear regression analyses to determine the independent associations of inflammatory cell subtypes, we have found that FPG had an independent incremental association with WBC (β±SE:4.2±1.4, p=0.004) and N (β±SE:4.2±1.2, p=0.001). Current smoking had an independent incremental association with WBC and all cell subtypes (for WBC, N, L, and M: β±SE: 748±161, p<0.001; β±SE: 556±136, p<0.001; β±SE: 185±69, p=0.007; β±SE: 38±20, p=0.061, respectively) and SUA had an independent incremental association with WBC (β±SE: 115±43, p=0.008), N (β±SE: 107±38, p=0.005) and M (β±SE: 26±6, p<0.001). Hypertension had an independent incremental association with WBC (β±SE: 431±140, p=0.002) and N (β±SE: 315±118, p=0.008). Male gender had an independent incremental association with only M (β±SE: 52±20, p=0.010). Family history of CAD had an independent decremental association with WBC (β±SE: -327±139, p=0.019) and N (β±SE: -326±121, p=0.007). Finally, age had an independent decremental association with WBC (β±SE: -32±7, p<0.001) and L (β±SE: -16±3, p<0.001). The N/L ratio was independently related with increased age (p<0.001), FPG (p=0.003) and SUA (p=0.012). Conclusion: Our study results demonstrate that leukocyte subtypes have different specific associations with traditional CVRFs. We found that FPG affects specifically N while SUA affects specifically N and M, and current smoking affects nonsp...

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“…Leukocytosis, especially increased neutrophils and decreased lymphocyte count increase BP in Blacks by 6/2 mmHg in the highest vs the lowest tertile [38] . Macrophages and various T-cell subtypes regulate BP, invade the arterial wall, activate TLRs and induce autoimmune vascular damage [38,39] . Angiotensin Ⅱ activates immune cells (T cells, macrophages and dendritic cells) and promotes cell infiltration into target organs [39] .…”

Section: Autoimmune Dysfunctionmentioning

confidence: 91%

“…38 target organ damage (TOD). Nutrient-gene interactions, subsequent gene expression, epigenetics, oxidative stress, inflammation and autoimmune vascular dysfunction have positive or negative influences on vascular biology in humans.…”

Section: Reviewmentioning

confidence: 99%

“…This includes salt-sensitive hypertension with increased renal inflammation as a result of T cell imbalance, dysregulation of CD4 + and CD8 + lymphocytes and chronic leukocytosis with increased neutrophils and reduced lymphocytes [36][37][38] . Leukocytosis, especially increased neutrophils and decreased lymphocyte count increase BP in Blacks by 6/2 mmHg in the highest vs the lowest tertile [38] . Macrophages and various T-cell subtypes regulate BP, invade the arterial wall, activate TLRs and induce autoimmune vascular damage [38,39] .…”

Section: Autoimmune Dysfunctionmentioning

confidence: 99%

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The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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Association between circulating specific leukocyte types and blood pressure: the Atherosclerosis Risk in Communities (ARIC) study

Abstract: Background-Although total white blood cell (WBC) count has been associated with hypertension, the association between specific WBC types and blood pressure (BP) levels has not been studied.

Cited by 34 publications

References 58 publications

Relation of neutrophil/lymphocyte ratio to resistant hypertension

Relation of neutrophil/lymphocyte ratio to resistant hypertension

The particular interactions of the traditional cardiovascular risk factors with different circulating specific leukocyte subtype counts in blood: an observational study

The role of nutrition and nutraceutical supplements in the treatment of hypertension

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