Association between circulating tumor necrosis factor-related biomarkers and estimated glomerular filtration rate in type 2 diabetes

Kamei, Nozomu; Yamashita, Mami; Nishizaki, Yuji; Yanagisawa, Naotake; Nojiri, Shuko; Tanaka, Kanako; Yamashita, Yoshihisa; Shibata, Terumi; Murakoshi, Maki; Suzuki, Yusuke; Gohda, Tomohito

doi:10.1038/s41598-018-33590-w

Cited by 36 publications

(28 citation statements)

References 41 publications

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“…The molecular weight of sTNFR1 is just 55 KD, and despite some presumed ectodomain cleavage of the receptor, is the predominant form of sTNFR1 found in human sera 12 . A contribution of plasma accumulation of the receptor as GFR declines through reduced renal clearance is therefore possible and, indeed, sTNFR1 levels are detectable in urine, and serum levels have been reported to correlate with eGFR in cross-sectional studies [13][14][15] . However, the present results could also be consistent with the growing body of evidence implicating sTNFR in the pathogenic processes that promote GFR loss in diabetes 6,16,17 .…”

Section: Discussionmentioning

confidence: 99%

Changes in soluble tumor necrosis factor receptor type 1 levels and early renal function decline in patients with diabetes

MacIsaac

Farag

Obeyesekere

et al. 2019

J of Diabetes Invest

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The relationship between serial changes in soluble tumor necrosis factor receptor type 1 (TNFR1) levels and an early decline in estimated glomerular filtration rate (eGFR) decline remains to be defined. We found that in patients with an early decline in renal function (n = 30), soluble TNFR1 values increased (2,595 ± 683 vs 3,596 ± 1,203 pg/mL, P < 0.001) as eGFR decreased (89 ± 1 vs 51 ± 2 mL/min/1.73m2, P < 0.001) over an 8‐year period. In contrast, there were no significant changes in soluble TNFR1 levels in patients with stable renal function (n = 17). In a multilevel mixed effects regression model, changes in soluble TNFR1 levels were found to be independently associated with eGFR decline (Z = −4.31, P < 0.001). An early decline in eGFR is associated with an increase in soluble TNFR levels; however, the factors driving this increase and the possible pathological role that soluble TNFR1 plays in progressive diabetic kidney disease remain to be determined.

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Section: Discussionmentioning

confidence: 99%

Changes in soluble tumor necrosis factor receptor type 1 levels and early renal function decline in patients with diabetes

MacIsaac

Farag

Obeyesekere

et al. 2019

J of Diabetes Invest

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“…The use of serum biomarkers is an interesting approach to assess (patho)physiological processes and therapeutic responses. Serum biomarkers are used in the identification and management of several diseases, including heart failure [5], myocardial infarction [6], cancer [7], and diabetes [8]. So far, no specific serum biomarkers to assess AF stage and to predict the outcome of AF treatment are available.…”

Section: Introductionmentioning

confidence: 99%

Cell-Free Circulating Mitochondrial DNA: A Potential Blood-Based Marker for Atrial Fibrillation

Wiersma

Marion

Bouman

et al. 2020

Cells

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Atrial fibrillation (AF), the most common, progressive tachyarrhythmia is associated with serious complications, such as stroke and heart failure. Early recognition of AF, essential to prevent disease progression and therapy failure, is hampered by the lack of accurate diagnostic serum biomarkers to identify the AF stage. As we previously showed mitochondrial dysfunction to drive experimental and human AF, we evaluated whether cell-free circulating mitochondrial DNA (cfc-mtDNA) represents a potential serum marker. Therefore, the levels of two mtDNA genes, COX3 and ND1, were measured in 84 control patients (C), 59 patients undergoing cardiac surgery without a history of AF (SR), 100 paroxysmal (PAF), 116 persistent (PeAF), and 20 longstanding-persistent (LS-PeAF) AF patients undergoing either cardiac surgery or AF treatment (electrical cardioversion or pulmonary vein isolation). Cfc-mtDNA levels were significantly increased in PAF patients undergoing AF treatment, especially in males and patients with AF recurrence after AF treatment. In PeAF and LS-PeAF, cfc-mtDNA levels gradually decreased. Importantly, cfc-mtDNA in serum may originate from cardiomyocytes, as in vitro tachypaced cardiomyocytes release mtDNA in the medium. The findings suggest that cfc-mtDNA is associated with AF stage, especially in males, and with patients at risk for AF recurrence after treatment.

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“…Several studies have reported increased circulating PGRN concentrations in patients with metabolic diseases such as diabetes and obesity 6 , 7 . Additionally, we have previously shown that circulating PGRN concentrations are significantly increased in patients with type 2 diabetes and renal functional decline 8 . These findings raise the possibility that PGRN may exert beneficial or harmful effects depending on the affected organ or pathological condition.…”

Section: Introductionmentioning

confidence: 93%

Differential organ-specific inflammatory response to progranulin in high-fat diet-fed mice

Murakoshi

Gohda

Adachi

et al. 2021

Sci Rep

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Progranulin (PGRN) has been reported to bind tumor necrosis factor (TNF) receptor and to inhibit TNFα signaling. We evaluated the effect of augmentation of TNFα signaling by PGRN deficiency on the progression of kidney injury. Eight-week-old PGRN knockout (KO) and wild-type (WT) mice were fed a standard diet or high-fat diet (HFD) for 12 weeks. Albuminuria, markers of tubular damage, and renal mRNA levels of inflammatory cytokines were higher in HFD-fed KO (KO-HFD) mice than in HFD-fed WT (WT-HFD) mice. Body weight, vacuolization in proximal tubules, and systemic and adipose tissue inflammatory markers were lower in the KO-HFD mice than in the WT-HFD mice. The renal megalin expression was lower in the KO mice than in the WT mice regardless of the diet type. The megalin expression was also reduced in mouse proximal tubule epithelial cells stimulated with TNFα and in those with PGRN knockdown by small interfering RNA in vitro. PGRN deficiency was associated with both exacerbated renal inflammation and decreased systemic inflammation, including that in the adipose tissue of mice with HFD-induced obesity. Improved tubular vacuolization in the KO-HFD mice might partially be explained by the decreased expression of megalin in proximal tubules.

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Association between circulating tumor necrosis factor-related biomarkers and estimated glomerular filtration rate in type 2 diabetes

Cited by 36 publications

References 41 publications

Changes in soluble tumor necrosis factor receptor type 1 levels and early renal function decline in patients with diabetes

Changes in soluble tumor necrosis factor receptor type 1 levels and early renal function decline in patients with diabetes

Cell-Free Circulating Mitochondrial DNA: A Potential Blood-Based Marker for Atrial Fibrillation

Differential organ-specific inflammatory response to progranulin in high-fat diet-fed mice

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