Association between cognition and daily life functioning in dementia subtypes

Abstract

The association between cognition and daily life functioning varied among dementia subtypes for AD, VaD, FTD and PD. Furthermore, the overall scores on both domains differ between dementia subtypes, indicating that different types of dementia are characterized by a specific pattern of cognitive status and daily life functioning. These findings underline the need for multidomain assessment in patients with dementia.

Cognitive and Neuropsychiatric Symptom Differences in Early Stages of Alzheimer’s Disease: Kuopio ALSOVA Study

“…In our study, cognition was significantly associated with ADL. These results are consistent with those from previous studies conducted with the CERAD total score [22] or other cognitive measures [4, 5, 7, 8, 9]. Women received better scores in the ADCS-ADL, which probably reflects the traditional way to share housework in marriages in this generation, and this needs to be taken into account when using ADL measures.…”

“…In addition, neuropsychiatric symptoms, such as depression, apathy and agitation, seem to be common already in early stages of AD and can have an impact on both patients’ and care-givers’ well-being [1, 2, 3]. Cognitive performance has been consistently associated with functional ability [4, 5, 6, 7, 8]; however, the association of neuropsychiatric symptoms with cognition and daily functioning is unclear [7, 9, 10, 11, 12, 13], in spite of the fact that the amount of neuropsychiatric symptoms seems to increase in patients with more advanced dementia [14, 15]. Thus, more information is needed to elucidate how these features of AD are interrelated.…”

Activities of Daily Living in Progressive Non-Fluent Aphasia, Logopenic Progressive Aphasia and Alzheimer’s Disease

“…By contrast, there has been limited research investigating ADLs in other dementias. Recent studies have shown that patients with PNFA are not as functionally impaired as patients with AD [9], and that cognition is more affected than ADLs [11]. Behavioural disturbances are also present in patients with PNFA [12][13][14], although ADLs in PNFA, LPA and AD they were not reported as being significantly disturbing by their carers.…”

Interview for Deterioration in Daily Living Activities in Dementia: construct and concurrent validity in patients with mild to moderate dementia

“…Furthermore, ADL measurements differ in their responsiveness to drugs and psychosocial interventions depending on the state of dementia (Desai et al, 2004;Sikkes et al, 2009;Bouwens et al, 2009;Gauthier et al, 2010;Voigt-Radloff and Hüll, 2011). Low correlations of cognition not only with the IDDD but also with the other ADL measurements (PRPP; ADCS-ADL; Table 6) emphasize the conceptual differences between these constructs.…”