Association between dental health and obstructive coronary artery disease: an observational study

Lee, Ho; Kim, Hack‐Lyoung; Jin, Kwang Nam; Oh, Sohee; Han, Yoon-Sic; Jung, Da Un; Sim, Hye-Young; Kim, Hee Sun; Lim, Woo Hyun; Seo, Jae Bin; Kim, Sang Hyun; Zo, Joo Hee; Kim, Myung A.

doi:10.1186/s12872-019-1080-9

Cited by 12 publications

(9 citation statements)

References 31 publications

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“…Our findings also demonstrated that both edentulism and periodontitis are related to CAD and the edentulism could increase the odds ratio of CAD, like periodontitis. These results are consistent with studies showing an association between tooth loss and CAD 18,19,32,34,61‐63 . Zanella et al 18 found a significant interrelation between numerous tooth loss and vascular occlusion.…”

Section: Discussionsupporting

confidence: 90%

“…These results are consistent with studies showing an association between tooth loss and CAD. 18,19,32,34,[61][62][63] Zanella et al 18 found a significant interrelation between numerous tooth loss and vas- and they showed that CHD group had remarkably less teeth rather than the control group. In a meta-analysis study consisted of cohort studies, Bahekar et al 63 showed that subjects having less than 10 teeth exhibited 1.24 times more likely to develop CHD.…”

Section: Discussionmentioning

confidence: 99%

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Relationship of periodontitis and edentulism to angiographically diagnosed coronary artery disease: A cross‐sectional study

Çetin

Önder

Orhan

et al. 2020

J of Periodontal Research

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Objective: The objective of the study is to examine the connection between oral status and the extent of coronary artery disease (CAD), which is diagnosed by angiography. Background: Periodontitis and tooth loss have been linked to atherosclerosis and CAD in previous studies. However, no distinct connection was revealed due to the diversity of the results and the variety of diagnostic methods. To provide a more consistent data pool and stronger evidence, there is a need for studies with standard measurements and diagnostic criteria. Methods: 309 patients, who consulted to Ankara University, Faculty of Medicine, Department of Cardiology and had coronary angiography, were enrolled to this study. Individuals were grouped based on their coronary angiography results, as CAD (+) (n = 233) and CAD (−) (n = 76). Studied parameters included cardiovascular risk factors, plaque index (PI), remaining teeth count, bleeding on probing (BOP), and probing pocket depth (PPD). Periapical radiographs were taken from teeth with ≥4 mm PPD. Oral status was categorized as periodontally healthy subjects/patients with gingivitis (Group 1), patients with periodontitis (Group 2), and edentulous subjects (Group 3). Results: PI (P < 0.001), PPD (P = 0.001), BOP (P = 0.004), the number of patients with less than 10 teeth (P = 0.014), and edentulism (P = 0.009) were significantly higher in CAD (+) patients, who were mostly older (P < 0.001) and male (P < 0.001). Multivariate logistic regression analysis revealed that Group 2 (odds ratio = 2.48, 95% confidence interval = 1.24-4.95, P = 0.010) and Group 3 (odds ratio = 2.01, 95% confidence interval = 1.14-5.17, P = 0.040) were highly associated with CAD. Two and three stenosed vessels were significantly higher in Groups 2 and 3 compared to Group 1 (P = 0.003). Conclusions: It was found that both edentulism and periodontitis were related to CAD.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Relationship of periodontitis and edentulism to angiographically diagnosed coronary artery disease: A cross‐sectional study

Çetin

Önder

Orhan

et al. 2020

J of Periodontal Research

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“…The link between periodontal disease and angiographically verified coronary disease has been well established in stable coronary artery disease and acute coronary syndromes [ 20 , 21 , 22 , 23 ]. Nonetheless, it is still a matter of debate whether PD is an independent risk factor for CAD or whether the association is based on an abundance of shared risk factors, including, amongst others: age, gender, smoking, diabetes mellitus, hypertension, obesity, low socioeconomic status, and stress [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Oral Health of Patients Undergoing Percutaneous Coronary Intervention—A Possible Link between Periodontal Disease and In-Stent Restenosis

Nagy

Gheorghita

Dharmarajan³

et al. 2023

JPM

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Introduction: There is a well-documented association between coronary artery disease (CHD) and periodontal disease (PD) mediated by common inflammatory pathways. This association, however, has not been investigated extensively in the special context of in-stent restenosis. This study aimed to investigate the periodontal status of patients undergoing percutaneous coronary intervention (PCI) for restenotic lesions. Methods and Results: We enrolled 90 patients undergoing percutaneous coronary intervention and 90 age- and gender-matched healthy controls in the present study. All subjects received a full-mouth examination by a periodontist. Plaque index, periodontal status, and tooth loss were determined. The periodontal state was significantly worse (p < 0.0001) in the PCI group, and each periodontal stage increased the odds of belonging to the PCI group. This effect of PD was independent of diabetes mellitus, another strong risk factor for CAD. The PCI group was further divided into two subgroups: PCI for restenotic lesions (n = 39) and PCI for de novo lesions (n = 51). Baseline clinical and procedural characteristics were comparable between the two PCI subgroups. A significant (p < 0.001) association was found between the PCI subgroup and the severity of periodontal disease, with the incidence of severe PD reaching 64.1%. Conclusions: Patients undergoing PCI for in-stent restenosis exhibit more severe forms of periodontal disease not only as compared to healthy controls but also as compared to patients stented for de novo lesions. The potential causality between PD and restenosis must be studied in larger prospective studies.

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“…The form, which was created by the researchers by reviewing the literatüre [1][2][3][4][5], evaluating the sociodemographic characteristics of the individuals and their status related to dental treatment and cardiovascular disease (19 items) was used to collect data. The study also used a questionnaire to determine the presence of infective endocarditis signs and symptoms (11 items; yes, no; 2-point Likert type), the risk of developing infective endocarditis (20 items; yes, no; 2-point Likert type), and the level of knowledge of Oral Dental Health and Infective Endocarditis (17 items; strongly disagree, disagree, undecided, agree, strongly agree; 5-point likert type) created by the researchers in accordance with the literatüre [5][6][7][8][9][10]. The questionnaire used in the study consists of 67 items in total.…”

Section: Data Collection Toolsmentioning

confidence: 99%

Determination of Infective Endocarditis Development Risks and Knowledge Levels of Individuals Applying for Dental Treatment

Uysal

Iremnur

2022

NHC

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Objective: In the study, it was aimed to determine the risk and level of knowledge of individuals who applied to the clinic for dental treatment. Methods: The research consisted of 713 adult individuals who went to the dental clinic for dental treatment between 01 March and 31 August 2020, who were willing to participate in the study and who met the inclusion criteria. The questionnaires developed by the researchers were used to determine the risks of developing infective endocarditis, and the knowledge levels of Oral and Dental Health and Infective Endocarditis in individuals who attended dental treatment. Descriptive statistical analyzes were made. Results: In the study, the rate of agreeing that "oral and dental health problems are as important as other health problems" (p = 0.005) and that "infective endocarditis disease is an infection of the heart and its valves" (p = 0.009) was found to be significantly higher in females than males. It was determined that the majority of the individuals (38.7%) were indecisive about the idea that “antibiotics should be used before dental treatment”. When the infective endocarditis risk factors were evaluated in the study, it was found that 8.1% had piersing in their body, 28.3% had problems such as gingivitis, bleeding and swelling. Conclusion: The most important issue in preventing the development of infective endocarditis is to increase the awareness of individuals. The society should be made aware of the risk factors that may cause infective endocarditis and their knowledge level should be increased.

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Association between dental health and obstructive coronary artery disease: an observational study

Cited by 12 publications

References 31 publications

Relationship of periodontitis and edentulism to angiographically diagnosed coronary artery disease: A cross‐sectional study

Relationship of periodontitis and edentulism to angiographically diagnosed coronary artery disease: A cross‐sectional study

Oral Health of Patients Undergoing Percutaneous Coronary Intervention—A Possible Link between Periodontal Disease and In-Stent Restenosis

Determination of Infective Endocarditis Development Risks and Knowledge Levels of Individuals Applying for Dental Treatment

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