Association between depression and malnutrition–inflammation complex syndrome in patients with continuous ambulatory peritoneal dialysis

Z, Li; An, Xin; Mao, Haiping; Wei, Xin; Chen, Jiehui; Yang, Xiao; Zhou, Shu‐Feng; Li, Zhibin; Yu, Xueqing

doi:10.1007/s11255-011-9917-x

Cited by 39 publications

(35 citation statements)

References 35 publications

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“…28 In another study using The Hamilton Depression Scale (HAMD), serum CRP closely correlated with depression score in CAPD patients. 29 However, other studies could not demonstrate such a relationship between CRP and inflammation. [30][31][32] Using different cutoff points for screening and diagnosis of depression symptoms by assessment tools may be a possible reason for the contradictory results of different studies.…”

Section: Discussionmentioning

confidence: 95%

Serum apelin is associated with affective disorders in peritoneal dialysis patients

et al. 2016

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Objective: Depression and anxiety are prevalent affective disorders in peritoneal dialysis (PD) patients. Recent research has proposed a potential role of apelinergic system in pathogenesis of depression. The present study aimed to evaluate the frequency of depression and anxiety and their potential relation with serum apelin levels among PD patients. Methods: A total of 40 PD patients were enrolled into the study. Depressive symptoms and anxiety were assessed with the Beck's Depression Inventory and the Beck's Anxiety Inventory. Serum apelin-12 levels were measured by immunoenzymatic assays using commercially available ELISA kit for standard human apelin. Results: Of the patients, 16 (40%) had depression, 20 (50%) had anxiety. The patients with depression and anxiety had a significantly longer time on dialysis (p < 0.001 for both), significantly higher serum apelin (p < 0.001 for both) and C-reactive protein levels (p < 0.001 for both) than those without depression and anxiety. In multivariate analysis, serum apelin was the only parameter associated independently with depression and anxiety scores. Conclusions: A substantial number of PD patients had depression and anxiety. Increased levels of serum apelin may constitute a significant independent predictor of development of depression and anxiety in PD patients. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 95%

Serum apelin is associated with affective disorders in peritoneal dialysis patients

et al. 2016

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“…These malnourished patients had lower albumin and higher CRP levels as expected. It is well known that malnutrition in dialysis patients is closely associated with chronic inflammation as a part of malnutrition-inflammationatherosclerosis syndrome (MIA) and at the end, is one of the and the malnutrition-inflammation score was independent risk factor for depression in peritoneal dialysis patients (27). Similarly Micozkadioglu et al reported an association between depressive findings and malnutrition-inflammation complex in hemodialysis patients (28).…”

Section: Türk Nefroloji Diyaliz Ve Transplantasyon Dergisi Turkish Nementioning

confidence: 98%

Association of Nutritional Status with Depression and Sleep Disorders in Elderly End Stage Renal Disease Patients - Does Chronic Inflammation Cause it all?

Bilgic¹,

Ibis²,

Tutal³

et al. 2012

Turk Neph Dial Transpl

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OBjEcTIvE: In our study we aimed to analyze the association between nutritional status and depression and sleep disturbance in elderly dialysis patients. mATErIAl and mEThOdS: Seventy-three patients receiving dialysis treatment older than 65 years of age were enrolled in this study. Nutritional status was determined by Subjective Global Assessment (SGA). Patients were also evaluated with Beck Depression Inventory and Pittsburg Sleep Quality Index. Demographic and laboratory data were recorded.rESulTS: According to SGA, 48 (65.8%) patients were well nourished and 25 (34.2%) patients had mild-moderate and severe malnutrition. When the well-nourished and malnourished patients were compared, the well-nourished group had higher albumin (p<.0001) and creatinine (p=.03) levels, higher body mass indices (p<.01), lower CRP levels (p<.0001), better quality of sleep (p<.0001) and lower depression scores (p<.0001) than the malnourished group. When we grouped patients as Group I (not depressive and good sleep quality), Group II (depressive but good sleep quality) and Group III (both depressive and poor sleep quality, we found that Group III had the lowest albumin (p < .0001) and highest CRP (p < .0001) values when compared to the other two groups.cOncluSIOn: Depression, sleep disorders, and the nutritional status are important factors which interact with each other and elderly dialysis patients with malnutrition should be well assessed for the presence of any inflammatory status and/or psychological-sleep disorders.KEy wOrdS: Elderly patients, Dialysis, Malnutrition, Depression, Sleep disorder Öz AmAç: Çalışmamızda yaşlı diyaliz hastalarında beslenme durumu ile depresyon ve uyku bozukluğu arasındaki ilişkiyi incelemeyi amaçladık. gErEç ve yÖnTEmlEr: Çalışmaya diyaliz tedavisi almakta olan 65 yaş üzerindeki 73 hasta alındı. Beslenme durumu "Subjektif Global Değerlendirme (SGD)" ile belirlendi. Hastalar ayrıca "Beck Depresyon Görüşmesi" ve "Pittsburg Uyku Kalitesi İndeksi" ile değerlendirildi. Hastaların demografik ve laboratuvar verileri kaydedildi.BulgulAr: SGD sonuçlarına göre, 48 (%65.8) hastanın beslenme durumu iyi düzeyde iken 25 (%34.2) hasta hafif-orta ve ciddi derecede beslenme bozukluğuna sahipti. Beslenme durumu iyi olan hastalar ile malnutrisyonu olan hastalar karşılaştırıldığında, beslenmesi iyi olan grubun daha yüksek albümin (p<0,0001) ve kreatinin (p=0,03) düzeyleri ile vücut kitle indeksine (p<0,01), daha düşük CRP düzeylerine (p<.0001), daha iyi uyku kalitesine (p<0,0001) ve daha düşük depresyon skorlarına (p<0,0001) sahip olduğu görüldü. Hastaları, Grup I (depresyonu olmayan ve iyi uyku kalitesine sahip), Grup II (depresyonu olan ancak iyi uyku kalitesine sahip), Grup III (depresyonu olan ve kötü uyku kalitesine sahip) şeklinde gruplandığımızda Grup III'ün diğer gruplara kıyasla en düşük albümin (p<0,0001) ve en yüksek CRP (p<0,0001) düzeylerine sahip olduğu bulundu.SOnuç: Depresyon, uyku bozuklukları ve beslenme durumu birbirleriyle ilişkili önemli etkenlerdir ve malnutrisyonu olan yaşlı diyaliz has...

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“…Recently, many authors try to investigate the connection between depression and inflammatory status in ESRD patients. 31 Meanwhile, the disorder of ApoE may be influenced by inflammatory cytokines in the dialysis population, though there is no difference in hsCRP between the two groups. 32 A few limitations in the current study should be noted.…”

Section: Patient Groupmentioning

confidence: 99%

Frequencies of apolipoprotein E alleles in depressed patients undergoing hemodialysis – a case-control study

Zhang

Shen

et al. 2015

Renal Failure

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Objective: To explore the relation between the frequencies of apolipoprotein E (ApoE) alleles and the occurrence of depression in patients undergoing hemodialysis in a Chinese population. Methods: We examined the ApoE alleles in a sample of 288 subjects: 72 patients with depression under hemodialysis, 74 patients without depression under hemodialysis, 75 patients with depression under nondialytic treatment and 67 patients without depression under nondialytic treatment. The depression state was assessed using the Center for Epidemiological Studies Depression (CES-D) scale. Associations between the occurrence of depression and the frequencies of ApoE alleles were examined using multinomial logistic regression models with adjustment of relevant covariates. Information about sociodemographics, clinical data, vascular risk factors and cognitive function was also collected and evaluated. Results: The frequencies of ApoE-"2 were significantly different between depressed and non-depressed patients irrespective of dialysis (p50.05), but no significant difference was found in the frequencies of ApoE-"4 (p40.05). Serum ApoE levels were significantly different between depressed and nondepressed patients in the whole sample (p50.05). Multinomial logistic regression models showed significant association between the frequency of ApoE-"2 and the occurrence of depression in the Chinese population after control of relevant covariates, including age, sex, educational level, history of smoking and drinking, vascular risk factors and cognitive function. Conclusions: No association between the frequency of ApoE-"4 and the occurrence of depression was found in patients undergoing hemodialysis. Further research is needed to find out if ApoE-"2 acts as a protective factor in Chinese dialysis population since it might decrease the prevalence of depression and delay the onset age.

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Association between depression and malnutrition–inflammation complex syndrome in patients with continuous ambulatory peritoneal dialysis

Abstract: Depression is commonly encountered in Chinese CAPD patients. A close relationship exists between depression and MICS.

Cited by 39 publications

References 35 publications

Serum apelin is associated with affective disorders in peritoneal dialysis patients

Serum apelin is associated with affective disorders in peritoneal dialysis patients

Association of Nutritional Status with Depression and Sleep Disorders in Elderly End Stage Renal Disease Patients - Does Chronic Inflammation Cause it all?

Frequencies of apolipoprotein E alleles in depressed patients undergoing hemodialysis – a case-control study

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