Association between Dietary Niacin Intake and Migraine among American Adults: National Health and Nutrition Examination Survey

Liu, Huanxian; Wang, Lu; Chen, Chun-Fu; Dong, Zhao; Yu, Shengyuan

doi:10.3390/nu14153052

Cited by 67 publications

(38 citation statements)

References 38 publications

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“…Other studies hold points that are similar to ours. Liu et al found that individuals who consumed more niacin had a lower incidence of Accepted Manuscript hypertension and diabetes [27]. Another study also proved that dietary niacin intake was negatively correlated with homeostasis model assessment of insulin resistance (HOMA-IR) (beta coefficient = -1.302, p = 0.009) and inflammatory markers in diabetes, adjusted for age, sex, BMI, and smoking [28].…”

Section: Discussionmentioning

confidence: 99%

Association of Dietary Niacin Intake with Diabetes in Adults in the United States

Liu

Duan

2023

Exp Clin Endocrinol Diabetes

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Objective: Previous studies have shown inconsistent associations between niacin supplementation and diabetes, and little is known about the relationship between dietary niacin intake and risk of diabetes in the general population. Our study aimed to explore the association between dietary niacin intake and risk of diabetes in the adult population in the United States. Methods: Data from the 2005–2016 National Health and Nutrition Examination Surveys were analyzed. Diabetes was diagnosed according to the American Diabetes Association criteria. Multivariate logistic regression models were used to estimate the association between dietary niacin intake and diabetes. Covariates included age, sex, race, family income, educational level, drinking status, smoking status, marital status, and physical activity. Results: This study included 24494 participants of which 13.63% had diabetes. In the fully adjusted model, a high niacin intake was significantly associated with a reduced risk of diabetes in a dose-dependent manner. When extreme quintiles of niacin intake were compared, the multivariable-adjusted OR was 0.66 (95% confidence interval: 0.49, 0.88) for diabetes, and per ten-unit increment in dietary niacin intake was associated with a 14% lower risk of diabetes. When niacin intake was less than 15.01 mg/d, a ten-unit increment in niacin intake was associated with a 24% higher risk of diabetes. However, the effect was not statistically significant. Conclusions: Our results suggest that consumption of adequate amounts of niacin can reduce the risk of diabetes. Furthermore, this protective effect disappeared when the niacin intake was insufficient (less than 15.01 mg/d).

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Section: Discussionmentioning

confidence: 99%

Association of Dietary Niacin Intake with Diabetes in Adults in the United States

Liu

Duan

2023

Exp Clin Endocrinol Diabetes

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“…Moreover, this set of measurement guidelines was specifically designed for use in the current NHANES setting and was agreed upon by experts during regular workshops to evaluate NHANES data collection (Ahluwalia et al, 2016). The NHANES Dietary Interviewer Procedures Manual involves a complete overview of dietary survey methods (Liu et al, 2022). To make the results more convincing, we used the average of 2 days of dietary niacin intake in the study.…”

Section: Methodsmentioning

confidence: 99%

Association between dietary niacin intake and cognitive function in the elderly: Evidence from NHANES 2011–2014

Shen

Yang

Liu

et al. 2023

Food Science & Nutrition

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Recent studies have shown an inconsistent association between dietary niacin and cognitive function. And this remains unclear in the American outpatient population.The aim of this study was to assess whether there is an association between dietary niacin and cognitive performance in an older American population aged ≥60 years. A total of 2523 participants from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 were enrolled. Cognitive function was assessed by the CERAD Word Learning (CERAD-WL) test, the CERAD Delayed Recall (CERAD-DR) test, the Animal Fluency test (AFT), and the Digit Symbol Substitution test (DSST). Cognitive impairment that meets one of the four scoring conditions listed above is defined as low cognitive function. Dietary niacin intake was obtained from 2 days of a 24-h recall questionnaire. Based on the quartiles of dietary niacin intake, they were divided into four groups: Q1 (<15.51 mg), Q2 (15.51-20.68 mg), Q3 (20.69-26.90 mg), and Q4(>26.91 mg). The stability of the results was assessed using multifactorial logistic regression, restricted cubic spline (RCS) models, and sensitivity stratified analysis. More than half of the participants had cognitive impairment (52.52%). In the fully adjusted model, niacin was associated with a significantly reduced risk of cognitive impairment in Q3 and Q4 compared with the Q1 group (OR: 0.610, 95% CI: 0.403, 0.921, p = .022; OR: 0.592, 95% CI: 0.367, 0.954, p = .034). Meanwhile, niacin was negatively associated with poor cognition as assessed by the CERAD-WL test, CERAD test, AFT, and DSST. An L-shaped dose-response relationship between dietary niacin and cognitive function was observed in all participants (nonlinear p < .001). There were also interactions that existed in populations with different carbohydrate intakes and cholesterol intakes (p for interaction = .031, p for interaction = .005). These findings provide new evidence for the potential role of dietary niacin intake on cognitive function in the elderly.

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“…The determination of migraine was based on an affirmative answer to the question: “Have you had a severe headache or migraine in the past 3 months?” in the Miscellaneous Pain section of the questionnaire. It is reasonable to consider individuals with severe headache in NHANES having migraine, 18–20 and a review of statistics about the American Migraine Prevalence and Prevention Study and four national surveillance studies based on the US population including NHANES supported the view that most of the “severe” headaches were in fact migraine 21 . Mortality data were obtained by linkage of the cohort database to the Centers for Disease Control's National Death Index as of December 31, 2019.…”

Section: Methodsmentioning

confidence: 99%

“…Family income was divided into three levels according to the poverty income ratio (PIR): low income (PIR ≤ 1.3), medium income (PIR = 1.3–3.5), and high income (PIR > 3.5) 26 . Smoking status was categorized as never, current, or former according to a previous study 19 . Participants were categorized according to alcohol drinking status as never (< 12 drinks in their lifetime), former (≥ 12 drinks in 1 year and did not drink last year, or did not drink last year but drank ≥ 12 drinks in their lifetime), or current drinkers (≥ 12 drinks in any 1 year and did drink last year).…”

Section: Methodsmentioning

confidence: 99%

“…26 Smoking status was categorized as never, current, or former according to a previous study. 19 Participants were categorized according to alcohol drinking status as never (< 12 drinks in their lifetime), former (≥ 12 drinks in 1 year and did not drink last year, or did not drink last year but drank ≥ 12 drinks in their lifetime), or current drinkers (≥ 12 drinks in any 1 year and did drink last year). A diagnosis of diabetes was based on any one of the following conditions: diagnosed by a doctor; 2-h oral glucose tolerance test blood glucose ≥ 11.1 mmol/L, random blood glucose ≥ 11.1 mmol/L, fasting glucose ≥ 7.0 mmol/L, or glycated hemoglobin HbA1c > 6.5% 27 ; or use of diabetes medications or insulin.…”

Section: Introductionmentioning

confidence: 99%

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Association between migraine and cardiovascular disease mortality: A prospective population‐based cohort study

Liu,

Zhang,

Gong

et al. 2023

Headache

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ObjectiveThe study assessed the association between migraine and cardiovascular disease (CVD) mortality in the US population.BackgroundPrevious studies have drawn different conclusions about the association between migraine and CVD mortality based on different populations; therefore, it is important to explore the relationship between migraine and CVD mortality in the US population.MethodsThis prospective cohort study included 10,644 participants from the National Health and Nutrition Examination Survey (NHANES) 1999–2004. Participants who reported having severe headache or migraine were classified as having migraine. Mortality data were obtained by linkage of the cohort database to the National Death Index as of December 31, 2019. Based on the International Classification of Diseases, Tenth Revision, CVD mortality includes the following disease codes: I00–I09 (acute rheumatic fever and chronic rheumatic heart diseases), I11 (hypertensive heart disease), I13 (hypertensive heart and renal disease), I20–I25 (ischemic heart diseases), I26–I28 (pulmonary embolism and other acute pulmonary heart diseases), I29 (various cardiovascular diseases caused by different reasons), I30–I51 (other forms of heart disease), and I60–I69 (cerebrovascular diseases). Data were analyzed from October to November 2022.ResultsAmong 10,644 adults included in the study (mean age, 46.4 [0.3] years, 5430 men [47.4%]), 2106 (20.4%) had migraine. During a median follow‐up period of 201 months, there were 3078 all‐cause deaths and 997 CVD deaths. Compared to individuals without migraine, those with migraine had an adjusted hazard ratio (HR) of 1.30 (95% confidence interval [CI], 1.04–1.62; p = 0.019) for CVD mortality and 1.23 (95% CI, 1.13–1.35; p < 0.001) for all‐cause mortality. In subgroup analyses, migraine was associated with CVD mortality in participants who were women (HR, 1.43; 95% CI, 1.06–1.93), aged < 45 years (HR, 1.69; 95% CI, 1.04–2.76), non‐Hispanic White (HR, 1.42; 95% CI, 1.09–1.86), those with a body mass index < 30 kg/m2 (HR, 1.36; 95% CI, 1.03–1.78), former or current smokers (HR, 1.36; 95% CI, 1.00–1.85), former or current alcohol drinkers (HR, 1.33; 95% CI, 1.03–1.72), and those without metabolic syndrome (HR, 1.31; 95% CI, 1.01–1.71). The association between migraine and CVD mortality was robust in sensitivity analyses, after excluding participants who died within 2 years of follow‐up (HR, 1.31; 95% CI, 1.05–1.65) or those with a history of cancer at baseline (HR, 1.28; 95% CI, 1.01–1.62).ConclusionsMigraine was associated with a higher CVD mortality rate in the US population.

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Association between Dietary Niacin Intake and Migraine among American Adults: National Health and Nutrition Examination Survey

Cited by 67 publications

References 38 publications

Association of Dietary Niacin Intake with Diabetes in Adults in the United States

Association of Dietary Niacin Intake with Diabetes in Adults in the United States

Association between dietary niacin intake and cognitive function in the elderly: Evidence from NHANES 2011–2014

Association between migraine and cardiovascular disease mortality: A prospective population‐based cohort study

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