Association between dioxin and cancer incidence and mortality: a meta-analysis

Abstract

The objective of the present study was to systematically assess the association between dioxin/2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and cancer incidence and mortality. Systematic literature searches were conducted until July 2015 in Pubmed, Embase and Cochrane library to identify relevant studies. A random-effects model was applied to estimate the pooled odds ratio (OR), risk ratio (RR), standard incidence ratio (SIR) or standard mortality ratio (SMR) for cancer incidence or mortality. In addition, dose-response, meta-regression, subgroup, and publication bias analyses were conducted. Thirty-one studies involving 29,605 cancer cases and 3,478,748 participants were included. Higher external exposure level of TCDD was significantly associated with all cancer mortality (pooled SMR = 1.09, 95% CI: 1.01–1.19, p = 0.04), but not all cancer incidence (pooled RR = 1.01, 95% CI: 0.97–1.06, p = 0.49). Higher blood level of TCDD was both significantly associated with all cancer incidence (pooled RR = 1.57, 95% CI: 1.21–2.04, p = 0.001) and all cancer mortality (pooled SMR = 1.45, 95% CI: 1.25–1.69, p < 0.001). Subgroup analysis suggested that higher external exposure and blood level of TCDD were both significantly associated with the mortality caused by non-Hodgkin’s lymphoma. In conclusion, external exposure and blood level of TCDD were both significantly associated with all cancer mortality, especially for non-Hodgkin’s lymphoma.

The aryl hydrocarbon receptor repressor – More than a simple feedback inhibitor of AhR signaling: Clues for its role in inflammation and cancer

“…Expression of RelB was also shown to be critical for survival of Hodgkin lymphoma (122). Interestingly, a recent meta-analysis found that exposure and increased blood levels of TCDD are significantly associated with the mortality caused by non-Hodgkin’s lymphoma (123). Furthermore, our previous reports strongly support the function of AhR to mediate an anti-apoptotic response in human lymphoma cells (124) and the vital role of RelB in AhR-mediated apoptotic resistance in human breast cancer cells (61, 66).…”

Manufacturing Industry Cancer Risk in Japan: A Multicenter Hospital-Based Case Control Study

“…The emission of dioxins and dioxin-like compounds into the atmosphere is clearly higher than in other industries except for food manufacturing (wood product manufacturing, 302.8970 mg-TEQ/year vs food manufacturing, 741.4960mg-TEQ/year)(Ministry of Economy, 2018). There have been reports that the most toxic dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin:TCDD) is statistically associated with cancer mortality (pooled standard mortality ratio = 1.09, 95%CI = 1.01-1.19) (Xu et al, 2016). However, there are no relevant data regarding the relationship between ambient dioxin exposure and cancer development (Xu et al, 2016;Danjou et al, 2019).…”

“…There have been reports that the most toxic dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin:TCDD) is statistically associated with cancer mortality (pooled standard mortality ratio = 1.09, 95%CI = 1.01-1.19) (Xu et al, 2016). However, there are no relevant data regarding the relationship between ambient dioxin exposure and cancer development (Xu et al, 2016;Danjou et al, 2019). As far as we know, a reduction in cancer risk, as shown in the present study has not been associated with wood products.…”

Cytochrome P450 1A2 activity and incidence of thyroid disease and cancer after chronic or acute exposure to dioxins

“…43 The tumorigenic potential of dioxins has been described in the literature, and TCDD is now classified as a human carcinogen by the International Agency for Research on Cancer (IARC) based on animal and human observational studies; in particular, non-Hodgkin lymphoma is particularly frequent. 44,45 However, this remains controversial as the evidences for a relationship between TCDD and human carcinogenesis are indirect. The 40-year follow-up of the Vietnam and Seveso populations did not conclude that TCDD exposure promotes an increase of cancer incidence.…”