Manufacturing Industry Cancer Risk in Japan: A Multicenter Hospital-Based Case Control Study

Kaneko, Rena; Sato, Yuzuru; Kobayashi, Yasuki

doi:10.31557/apjcp.2020.21.9.2697

Cited by 7 publications

(14 citation statements)

References 30 publications

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“…Utilizing ICOD-R occupational classification major groups, a relationship between occupations that harbor high physical activity and the reduction of cancer risk was demonstrated [12]. By comparing the categories included in the manufacturing industry division of ICOD-R, it was shown that ureter cancer incidence in workers engaged in electronics is higher than that in workers in food manufacturing [22]. Therefore, it is justified to add the industrial/occupational classification to the confounding factors of GWAS for the examination of the development of cancer.…”

Section: Discussionmentioning

confidence: 99%

A Genome-Wide Association Study of Prostate Cancer Susceptibility Using Occupational and Environmental Factors as Confounding Factors

Takeuchi,

Hattori-Kato,

Okuno

et al. 2024

Cureus

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BackgroundIn addition to genetic predisposition, occupational and environmental factors are important for the risk of prostate cancer. We investigated the effect of single nucleotide polymorphisms (SNPs) on the development of prostate cancer in Japan, including occupational and industrial history as confounding factors in addition to age, smoking, and alcohol drinking. MethodsWe enrolled 210 prostate cancer patients and 504 male control patients. We conducted four genome-wide association study (GWAS) patterns for prostate cancer development. In the association test, logistic regression models incorporated age, smoking history, alcohol consumption history, and each pattern of industrial/occupational classification. ResultsNo SNPs satisfying the genome-wide significance level of 5×10 -8 were detected in GWAS. SNPs with a suggestive association level of 1×10 -6 were found near the long intergenic non-protein coding RNA 1824 (LINC01824) and tripartite motif family like 2 (TRIML2) genes in the GWAS using occupational history as a confounder and near the ribosomal protein S2 pseudogene 25 (RPS2P25) gene in the GWAS using industrial history as a confounder. No SNPs that met the suggestive association level were observed in the GWAS that did not include occupational and industrial history. ConclusionBy adding occupational and industrial history to the confounding factors, there were SNPs detected in the GWAS for prostate cancer development. The consideration of occupational and industrial history may increase the usefulness of GWAS.

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Section: Discussionmentioning

confidence: 99%

A Genome-Wide Association Study of Prostate Cancer Susceptibility Using Occupational and Environmental Factors as Confounding Factors

Takeuchi,

Hattori-Kato,

Okuno

et al. 2024

Cureus

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“…Kaneko et al used ICOD-R occupational classification major groups to demonstrate that occupations with high physical activity reduced the risk of cancer [ 27 ]. They also compared the categories included in the manufacturing industry division (Division E) of ICOD-R and noted that the incidence of ureter cancer in the electronics category is higher than that in the food manufacturing category [ 43 ]. Therefore, adding the industrial/occupational classification to the adjusting factors of GWAS, even if it is relatively rough, is considered to be meaningful in examining the development of cancer.…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Association Study Adjusted for Occupational and Environmental Factors for Bladder Cancer Susceptibility

Takeuchi

Hattori-Kato

Okuno

et al. 2022

Genes

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This study examined the effects of single-nucleotide polymorphisms (SNPs) on the development of bladder cancer, adding longest-held occupational and industrial history as regulators. The genome purified from blood was genotyped, followed by SNP imputation. In the genome-wide association study (GWAS), several patterns of industrial/occupational classifications were added to logistic regression models. The association test between bladder cancer development and the calculated genetic score for each gene region was evaluated (gene-wise analysis). In the GWAS and gene-wise analysis, the gliomedin gene satisfied both suggestive association levels of 10−5 in the GWAS and 10−4 in the gene-wise analysis for male bladder cancer. The expression of the gliomedin protein in the nucleus of bladder cancer cells decreased in cancers with a tendency to infiltrate and those with strong cell atypia. It is hypothesized that gliomedin is involved in the development of bladder cancer.

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“…For example, Oddone et al (2013) reported a case–control study in Italy that found that breast cancer incidence was associated with employment in textile, rubber, paper, and electrical manufacturing industries [ 18 ]. Kaneko et al (2020) conducted a case–control study investigating cancer risk among different manufacturing industries and found higher breast cancer risk among industries including clothing, chemicals, non-ferrous metals and products, and communication electronics, compared with a food manufacturing group [ 19 ]. Another study conducted in Canada found elevated breast cancer risk among female workers in plastics and rubber product fabricating industries [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer Incidence among Female Workers by Different Occupations and Industries: A Longitudinal Population-Based Matched Case–Control Study in Taiwan

Shen

Hsieh

Chuang

et al. 2022

IJERPH

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Background: Breast cancer is the leading cause of cancer incidence worldwide and in Taiwan. The relationship between breast cancer and occupational types remains unclear. This study aimed to investigate lifetime breast cancer incidence by different occupational industries among female workers in Taiwan. Methods: A population-based retrospective case–control study was conducted using three nationwide population-based databases. Matched case and control groups were identified with 1-to-4 exact matching among 103,047 female workers with breast cancer diagnosed in 2008–2017 and those without breast cancer. Their lifetime labor enrollment records were tracked using the National Labor Insurance Database, 1950–2017. Conditional logistic regression was used to analyze the association between types of occupational industries and risk of incident breast cancer. Results: Our study found slightly significant breast cancer risk among the following major occupational classifications: manufacturing (OR: 1.027, 95% CI: 1.011–1.043); wholesale and retail trade (OR: 1.068, 95% CI: 1.052–1.084); information and communication (OR: 1.074, 95% CI: 1.043–1.105); financial and insurance activities (OR: 1.109, 95% CI: 1.086–1.133); real estate activities (OR: 1.050, 95% CI: 1.016–1.085); professional, scientific, and technical activities (OR: 1.118, 95% CI: 1.091–1.145); public administration, defense, and social security (OR: 1.054, 95% CI: 1.023–1.087), education (OR: 1.199, 95% CI: 1.168–1.230); and human health and social work activities (OR: 1.125, 95% CI: 1.096–1.156). Conclusions: Greater percentages of industrial occupations (i.e., manufacturing, wholesale and retail, or health professionals) were associated with slightly increased breast cancer risk. Further studies should investigate the possible risk factors among female workers in those industries with slightly higher incidence of breast cancer.

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Manufacturing Industry Cancer Risk in Japan: A Multicenter Hospital-Based Case Control Study

Abstract: organic solvents (e.g., benzene, chloroform, and phenol), and asbestos(IARC, 1987). The risk may be linked with a combination of other exposures such as smoking or secondhand smoke (Alberg et al., 2013). It is important to account for the characteristics of carcinogen exposure

Cited by 7 publications

References 30 publications

A Genome-Wide Association Study of Prostate Cancer Susceptibility Using Occupational and Environmental Factors as Confounding Factors

A Genome-Wide Association Study of Prostate Cancer Susceptibility Using Occupational and Environmental Factors as Confounding Factors

Genome-Wide Association Study Adjusted for Occupational and Environmental Factors for Bladder Cancer Susceptibility

Breast Cancer Incidence among Female Workers by Different Occupations and Industries: A Longitudinal Population-Based Matched Case–Control Study in Taiwan

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