Association between DNA damage, DNA repair genes variability and clinical characteristics in breast cancer patients

Synowiec, Ewelina; Stefańska, Joanna; Morawiec, Zbigniew; Błasiak, Janusz; Woźniak, Katarzyna

doi:10.1016/j.mrfmmm.2008.09.014

Cited by 87 publications

(67 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a case-control study with more than 9,000 subjects, Pooley et al (35) found that a coding SNP (rs3218536) in one of the DNA double-strand break repair genes, XRCC2, was strongly associated with risk of developing PR-positive breast cancer. In another study, Synowiec et al (36) reported an association between the RAD51-135G/C polymorphism and PR expression (OR=6.33; 95% CI=1.15-35.01).…”

Section: Discussionmentioning

confidence: 93%

Genetic variants at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer

et al. 2011

View full text Add to dashboard Cite

Abstract. IQGAP1 knockout mice develop gastric cancer, but the IQGAP1 protein is associated with some advanced-stage human cancers. IQGAP1 expression is regulated by a microRNA, miR-124, through a binding site at the 3'-untranslated region, where a single nucleotide polymorphism (SNP) exists in the core binding region. We asked whether IQGAP1 expression is associated with breast cancer development and whether genetic variants at the miR-124 binding site are important. We genotyped the IQGAP1 SNP rs1042538 A/T in 1,541 breast cancer cases and 1,598 controls and analyzed the frequency of the variant and interactions with major risk factors in these populations. We also measured the expression of IQGAP1 at both mRNA and protein levels in different IQGAP1 genotypes. The IQGAP1 TT genotype, compared with the AA genotype, was associated with a significantly lower risk of developing breast cancer [P=0.049, odds ratio (OR), 0.78; 95% confidence interval (CI), 0.61-0.99]. In case-only analyses, the TT, compared with the AA, genotype was associated with progesterone receptor-positive subjects (OR, 1.35; 95% CI, 1.00-1.83). The expression levels of IQGAP1 protein were significantly higher in the TT genotype compated to the AA genotype. The presence of SNPs at the miR-124 binding site may be a marker for predicting breast cancer risk and prognosis.

show abstract

Section: Discussionmentioning

confidence: 93%

Genetic variants at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Out of the 55 abstracts retrieved through the search criteria, 25 were irrelevant, four articles [8][9][10][11] were excluded because they were conducted on overlapping populations with other eligible studies [2,3,5,12] (these excluded articles represent smaller studies performed on subsets of larger eligible studies), one study [13] was excluded given that it has not included controls in its study design, three articles [4,14,15] were reviews/meta-analyses, and three studies [16][17][18] were excluded due to other reasons (two of them [16,17] were excluded due to reporting reasons, i.e. no reporting of the relevant genotype frequencies, whereas the other [18] was excluded for examining the association between other XRCC3 polymorphisms and premenopausal breast cancer risk).…”

Section: Resultsmentioning

confidence: 99%

XRCC3 Thr241Met polymorphism and breast cancer risk: a meta-analysis

Economopoulos

Sergentanis

2009

Breast Cancer Res Treat

View full text Add to dashboard Cite

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. Abstract XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) is a member of the RecA/ Rad51-related protein family that participates in homologous recombination, maintaining chromosome stability and participating in DNA repair. Attention has been drawn upon the association of XRCC3 Thr241Met polymorphism with breast cancer risk. The present meta-analysis aims to examine whether XRCC3 Thr241Met polymorphism status is associated with breast cancer risk. Apart from the overall meta-analysis, separate analyses were performed on Chinese and non-Chinese populations, in order to investigate race-specific effects. Eligible articles were identified by a search of MEDLINE bibliographical database for the period up to August 2009. Twenty case-control studies on nonChinese subjects (19,575 cases and 21,125 controls) and three case-control studies on Chinese subjects (1,216 cases and 1,112 controls) were eligible. Pooled odds ratios (OR) were appropriately derived from fixed-effects or randomeffects models. At the overall analysis, the T allele was associated with elevated breast cancer risk mainly following a recessive model (pooled OR = 1.064, 95% CI: 1.007-1.124, fixed effects), given that the effect was more pronounced in homozygous carriers (pooled OR = 1.073, 95% CI: 1.010-1.140, fixed effects). The association seemed confined in non-Chinese populations, once again following a recessive model (pooled OR = 1.072, 95% CI: 1.014-1.133, fixed effects). Concerning Chinese populations, no consistent results were demonstrated. In conclusion, the XRCC3 Thr241Met T allele seems associated with elevated breast cancer risk in non-Chinese subjects. The need for additional studies on Chinese populations seems warranted.

show abstract

“…On the other hand, determined that there were polymorphic regions that were more frequently associated with melanoma skin cancer than cancer occurring in head, neck, bladder, and breast cancer. Th erefore, the eff ect of the XRCC3 gene varies in diff erent cancer types [31][32][33][34][35]. A recent study conducted in Poland focused on same genomic regions and cancer type, and has shown that the regions of interest are associated with cancer [19,20].…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in DNA repair genes XRCC2 and XRCC3 risk of gastric cancer in Turkey

et al. 2014

View full text Add to dashboard Cite

We studied the prevalence of polymorphisms in genes XRCC2 and XRCC3 in stomach cancer patients who lived in North Eastern Turkey. A total of 61 cancer patients and 78 controls were included in this study. Single nucleotide changes were studied in XRCC2 and XRCC3 genes at locus Arg188His and Th r241Met. Blood samples were taken from the patients and controls, and DNA was isolated. Th e regions of interest were amplifi ed using a polymerase chain reaction method. After amplifi cation, we used restriction enzymes (HphI and NcoI) to digest the amplifi ed product. Digested product was then run through gel electrophoresis. We identifi ed changes in the nucleotides in these specifi c regions. It was found that the Arg188His polymorphism of the XRCC2 gene was about 39 (24 out of the 61) among cancer patients. However, only 15 (12 out of 78) of the control group indicated this polymorphism. We also observed that 18 of the 61 cancer patients (29) carried the Th r241Met polymorphism of the XRCC3 gene whereas 11 of the 78 (14) individuals in the control group had the polymorphism. Our results showed a signifi cant diff erence in polymorphism ratios between the cancer patients and health control group for the regions of interest. Th is result clearly showed that these polymorphisms increase the risk of stomach cancer and might be a strong marker for early diagnosis of gastric cancer.

show abstract

Association between DNA damage, DNA repair genes variability and clinical characteristics in breast cancer patients

Cited by 87 publications

References 40 publications

Genetic variants at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer

Genetic variants at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer

XRCC3 Thr241Met polymorphism and breast cancer risk: a meta-analysis

Polymorphisms in DNA repair genes XRCC2 and XRCC3 risk of gastric cancer in Turkey

Contact Info

Product

Resources

About