Association between duration of dialysis and Helicobacter pylori infection in dialysis patients: a meta-analysis

Li, Kangjie; Chen, Ling

doi:10.1007/s11255-019-02205-2

Cited by 7 publications

(7 citation statements)

References 31 publications

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“…Other studies have also shown that the prevalence of HP infection decreases significantly as the duration of dialysis prolongs, especially within the first 4 years after the start of dialysis [8,9,27]. A meta-analysis of dialysis patients found that the HP infection rate was negatively correlated with the duration of dialysis [54]. Recently, two separate meta-analyzes reported a lower estimated prevalence of HP infection, such as 44% in ESRD patients and 48.2% in CKD patients compared to non-CKD patients [17,55].…”

Section: Discussionmentioning

confidence: 97%

“…Severe gastric mucosal atrophy leading to decreased H + secretion may occur in HD patients secreting inflammatory cytokines. In addition, secretion of inflammatory cytokines in HD patients cause severe chronic gastritis leading to decreased secretion of H + , and this affect the colonization of HP in the gastric mucosa [54,57]. In contrast, some studies have shown that high urea concentrations make the gastric mucosa more susceptible to HP, and uremic patients have a higher infection rate.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of endoscopic and pathological findings of the upper gastrointestinal tract in transplant candidate patients undergoing hemodialysis or peritoneal dialysis treatment: a review of literature

et al. 2020

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Background Dyspepsia is a common disorder in kidney transplant recipients, and the risk of post-transplant complications is increased in candidates with upper gastrointestinal disease. We evaluated gastrointestinal lesions of kidney transplant candidates on dialysis. Methods In this study, endoscopic and pathological findings in hemodialysis (HD) and peritoneal dialysis (PD) patients with gastrointestinal symptoms on the waiting list were compared. Results The most common non-ulcerous lesions in the endoscopic examination were gastritis (62.3%), erosive gastritis (38.7%), duodenal erosion or duodenitis (18.9%) and esophagitis (13.2%). The ulcerous lesion was present in only 3 patients. Gastroesophageal reflux disease, ulcerated lesion and non-ulcerated lesion rates were similar in both dialysis groups. Histopathological examination revealed Helicobacter pylori (HP) positivity in 28.3% of patients. HP positivity rate was significantly higher in PD patients than in HD patients (38.7% vs. 13.6%, p = 0.046). Chronic gastritis (75.5%) was the most common pathological finding. HP positivity rate was 37.5% in patients with chronic gastritis, but HP was negative in patients without chronic gastritis. In multivariate analysis, male gender, urea and albumin levels were associated with the presence of pathological chronic gastritis. The presence of gastritis, total cholesterol and ferritin levels were found significant for HP positivity. A total cholesterol > 243 mg/dL was significantly related to an increased risk of the presence of HP positivity. Conclusions Gastrointestinal lesions and HP infection are common in dialysis patients. Dialysis modality may affect the frequency of some lesions. It may be useful to have an endoscopic examination before entering the transplant waiting list for all candidates.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Comparison of endoscopic and pathological findings of the upper gastrointestinal tract in transplant candidate patients undergoing hemodialysis or peritoneal dialysis treatment: a review of literature

et al. 2020

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“…However, the relationship between Hp infection and kidney injury remains controversial. Recently, a metaanalysis showed that Hp infection might affect the prognosis of kidney diseases, and Hp was the main cause of secondary gastrointestinal diseases for patients with impaired renal function [31]. Several studies suggest that the prevalence of Hp might be lower in long-term dialysis patients than in short-term dialysis patients [32][33][34].…”

Section: Discussionmentioning

confidence: 99%

“…Another meta-analysis [41] showed that Type 2 diabetes (T 2 DM) patients with Hp infection had a 2 times higher risk of the occurrence of proteinuria than patients without Hp infection, indicating that Hp infection was associated with the occurrence of proteinuria in T 2 DM patients. Hp radical surgery might be a therapeutic option for protecting renal function in patients with T 2 DM [42].…”

Section: Discussionmentioning

confidence: 99%

Association between renal function and co-infection with Clonorchis sinensis and Helicobacter pylori: a cross-sectional study

Xie¹,

Deng

Chen³

et al. 2020

BMC Infect Dis

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Background Studies have shown that liver fluke infections may be associated with kidney injury and that Helicobacter pylori (Hp) may be involved in the pathogenesis of kidney diseases. However, no studies have reported the relationship between co-infection with Clonorchis sinensis (Cs) and Hp and renal function. The aim of this study was to examine the relationship between co-infection with Cs and Hp and estimated glomerular filtration rate (eGFR) in a general population, and gender-related differences were also investigated. Methods In the cross-sectional study, 4122 subjects from the Health Examination Center of Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine from January 2017 to December 2018 were enrolled. All participants underwent stool examination for the diagnosis of Cs infection and 13C-urea breath test (UBT) for the diagnosis of Hp infection. Participants were categorized into four groups: (1) co-infection with Cs and Hp group comprising 207 cases (Hp(+) + Cs(+) group), (2) Cs infection group comprising 1392 cases (Hp(−) + Cs(+)group), (3) Hp infection group comprising 275 cases (Hp(+) + Cs(−) group), and (4) non-infection group comprising 2248 cases (Hp(−) + Cs(−) group). Multiple linear regression analysis was performed to evaluate the relationship between co-infection with Cs and Hp and eGFR. Results Hp infection without Cs infection was present in 6.67% (275/4122) of subjects, while Cs infection without Hp infection was present in 33.77% (1392/4122) of subjects. Co-infection with Hp and Cs were present in 5.02% (207/4122) of subjects. Median age of the participants was 43 years (IQR 35–51). Most of the participants were male (2955/4122, 71.69%). Median eGFR was 96.61 ml/min/1.73 m2 (IQR 85.05–106.24). Co-infection with Cs and Hp was negatively associated with eGFR after full adjusting (β = − 1.89, 95% CI: − 3.33 to − 0.45, p = 0.01). The relationship remained significant in females (β = − 9.37, 95% CI: − 11.60 to − 7.1, p < 0.001), but not in males. Conclusion Our findings suggest that co-infection with Cs and Hp may be associated with reduced renal function in females, but not in males.

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“…pylori, insanlarda en yaygın görülen kronik bakteriyel enfeksiyondur ve gastrit, peptik ülser ve mide kanseri gibi çeşitli gastrointestinal hastalıklarla ilişkilidir. Böbrek fonksiyon bozukluğu olan hastalarda gastrointestinal hastalıkların ana nedenlerinden biri olarak kabul edilmektedir(17). Bununla birlikte, epidemiyolojik çalışmalarda H. pylori enfeksiyonu ve KBH arasındaki ilişki çelişkilidir(18).…”

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Kronik böbrek yetmezliği tanılı hastalarda üst gastrointestinal sisteme ait endoskopik ve histolojik bulguların değerlendirilmesi

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Cansız

et al. 2020

Akademik Gastroenteroloji Dergisi

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Kronik böbrek hastalarında (KBH), üst gastrointestinal sisteme (GİS) ait birçok semptom ve endoskopik bulgu görülebilmektedir (1). KBH hastalarında bu semptom ve bulgulara neden olabilecek mekanizmalar tam olarak bilinmemektedir. Gastrik ve duodenal mukozanın artmış duyarlılığı, yüksek açlık serum gastrin seviyeleri, kolesistokinin, nörotensin ve glukagon gibi gastrointestinal motilite düzenlenmesinde rol oynayan hormonların serum seviyelerindeki artış ve bu hastalarda hiperkalsemi, hipo-kalemi, asidoz gibi durumların sıklıkla görülmesinin gastroduodenal lezyonların ve semptomların gelişmesinde rol oynayabileceği ileri sürülmüştür (1,2). KBH hastalarında üst GİS bulguları oldukça sık görüldüğü için bu hastalarda endoskopik bulguların değerlendirildiği birçok çalışma yapılmıştır. Ancak bu çalışmalar arasında bazı tutarsızlıklar bulunmaktadır. Bazı çalışmalarda üst GİS'te KBH hastalarında kontrol grubuna göre daha fazla oranda erozyon, ülser, özofajit, gastrit, Helicobacter

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Association between duration of dialysis and Helicobacter pylori infection in dialysis patients: a meta-analysis

Cited by 7 publications

References 31 publications

Comparison of endoscopic and pathological findings of the upper gastrointestinal tract in transplant candidate patients undergoing hemodialysis or peritoneal dialysis treatment: a review of literature

Comparison of endoscopic and pathological findings of the upper gastrointestinal tract in transplant candidate patients undergoing hemodialysis or peritoneal dialysis treatment: a review of literature

Association between renal function and co-infection with Clonorchis sinensis and Helicobacter pylori: a cross-sectional study

Kronik böbrek yetmezliği tanılı hastalarda üst gastrointestinal sisteme ait endoskopik ve histolojik bulguların değerlendirilmesi

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