Association between egg and staphylococcal superantigen IgE sensitizations in atopic dermatitis

Ong, Peck Y.

doi:10.2500/aap.2014.35.3757

Cited by 12 publications

(3 citation statements)

References 11 publications

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“…One hypothesis is that the interaction between the microbial proteins and the skin and presence of homologous proteins between microbes and egg allergen may be related to the development of IgE sensitization and egg allergy [13]. In a study including 51 children with AD IgE sensitization to egg white there was a significant association with IgE sensitization to staphylococcal superantigens in older children [14]. The larger studies are needed for confirmation of these findings.…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin E-Mediated Food Allergies Differ in East Mediterranean Children Aged 0–2 Years

Kahveci

Koken

Şahiner

et al. 2020

Int Arch Allergy Immunol

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Objective: Precise diagnosis of allergy requires knowledge of the population's food allergy (FA) spectrum and predictors. Methods: Medical charts of Turkish children aged 0-2 years with FA and/or atopic dermatitis (AD) were reviewed. Results: A total of 1,389 patients, 912 with FA and 1,140 with AD, were included. In the FA group, the most frequently diagnosed FAs were egg white (75.9%), cow's milk (55.7%), tree nuts (31.5%) and sesame (20.6%). The detection of FA in 99% of children with any kind of FA necessitate testing with egg white, cow's milk, hazelnut, sesame, walnut, cashew, and pistachio. In the FA group, 72.7 and 56.8% had AD and multiple FA respectively. Multiple FA (56.8 vs. 49.8%) and hen's egg allergy (85.5 vs. 50.2%, p < 0.005) were more common and cow's milk allergy (51.4 vs. 67.1%, p < 0.005) less common in the AD subgroup of the FA group than in the non-AD subgroup. Multiple FA likelihood increases parallel to the severity of AD (p < 0.05). In the AD group, 58.2% had an immunoglobulin E-mediated FA. The risk of concomitant FA increased as the age at symptom onset of AD decreased (OR 0.800 [95% CI 0.731-0.875]; p < 0.001) and the severity of AD increased (OR 2.350 [95% CI 1.898-2.911]; p < 0.001). Conclusion: Although severe and early-onset AD is a predictor of the presence and magnitude of FA in infancy, the spectrum of FA is a reflection of cultural characteristics. The clinical presentations of both AD and FA may in fact be an expression of the extent of the immune dysregulation underlying atopy and allergy.

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Section: Discussionmentioning

confidence: 99%

Immunoglobulin E-Mediated Food Allergies Differ in East Mediterranean Children Aged 0–2 Years

Kahveci

Koken

Şahiner

et al. 2020

Int Arch Allergy Immunol

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“…Of the five common food allergens (cow's milk, egg white, soybean, wheat, and peanut), only IgE levels to egg white were associated significantly with the severity of AD in young children with AD. IgE sensitization to egg white was significantly associated with IgE sensitization to staphylococcal superantigens in older children (Ong, 2014). Another study was designed to evaluate an inner-city urban birth cohort to identify early environmental factors associated with AD and food allergy, as well as the incidence of wheezing during the first year of life.…”

Section: Discussionmentioning

confidence: 99%

Severity of atopic dermatitis in relation to food and inhalant allergy in adults and adolescents

Čelakovská

Bukač

2016

Food and Agricultural Immunology

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The aim of this study is the evaluation of the relationship between the severity of atopic dermatitis (AD) and the occurrence of IgEmediated food allergy, food sensitization, and sensitization to inhalant allergens. The complete dermatological and allergological examinations were performed and the severity of AD was evaluated with the SCORing Atopic Dermatitis index. The statistical evaluation of the relationship between the occurrence of IgE-mediated food allergy, food sensitization, sensitization to inhalant allergens, and the severity of AD was performed. Two hundred and eighty-three patients were examined, 89 men and 194 women, average age 26.2 (s.d. 9.5). The significant relation was recorded between the severity of AD and sensitization to tested inhalant allergens. The significant relation was also found between the severity of AD and IgE-mediated food allergy. It turns out that the higher time to reaction, the higher the severity of AD.

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“…Currently, however, there are no established laboratory tests for identifying these patients to implement early treatment. Ong 16 reports on the utility of food-specific IgE levels and superantigen-specific IgE levels as potential predictive markers of atopic dermatitis-associated morbidity.…”

mentioning

confidence: 99%

Allergic rhinitis: From discernment of symptoms to implementation of new therapeutic modalities

Bellanti¹,

Settipane²

2014

allergy asthma proc

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Association between egg and staphylococcal superantigen IgE sensitizations in atopic dermatitis

Abstract: Patients with moderately severe atopic dermatitis (AD)

Cited by 12 publications

References 11 publications

Immunoglobulin E-Mediated Food Allergies Differ in East Mediterranean Children Aged 0–2 Years

Immunoglobulin E-Mediated Food Allergies Differ in East Mediterranean Children Aged 0–2 Years

Severity of atopic dermatitis in relation to food and inhalant allergy in adults and adolescents

Allergic rhinitis: From discernment of symptoms to implementation of new therapeutic modalities

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