Association between endothelial and platelet function markers and adiponectin in renal transplanted recipients on cyclosporine and tacrolimus immunosuppression based therapy

Şahin, Garip; Akay, Olga Meltem; Uslu, Sema; Bal, Cengiz; Yalçın, Ahmet; Gülbaş, Zafer

doi:10.1111/nep.12413

Cited by 6 publications

(8 citation statements)

References 40 publications

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“…However, other data in KTRs have shown positive correlations between higher adiponectin levels and lower survival rates [ 21 ]. In a study by Sahin et al [ 188 ], adiponectin levels were significantly higher in patients receiving cyclosporine compared with those on tacrolimus. Malgorzewicz et al [ 189 ] suggested that higher leptin levels in obese patients are a risk factor for CVD and chronic rejection.…”

Section: Adipocytokines Role In Transplant Comorbiditiesmentioning

confidence: 99%

Adipocytokines in renal transplant recipients

et al. 2016

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In the last two decades, perceptions about the role of body fat have changed. Adipocytes modulate endocrine and immune homeostasis by synthesizing hundreds of hormones, known as adipocytokines. Many studies have been investigating the influences and effects of these adipocytokines and suggest that they are modulated by the nutritional and immunologic milieu. Kidney transplant recipients (KTRs) are a unique and relevant population in which the function of adipocytokines can be examined, given their altered nutritional and immune status and subsequent dysregulation of adipocytokine metabolism. In this review, we summarize the recent findings about four specific adipocytokines and their respective roles in KTRs. We decided to evaluate the most widely described adipocytokines, including leptin, adiponectin, visfatin and resistin. Increasing evidence suggests that these adipocytokines may lead to cardiovascular events and metabolic changes in the general population and may also increase mortality and graft loss rate in KTRs. In addition, we present findings on the interrelationship between serum adipocytokine levels and nutritional and immunologic status, and mechanisms by which adipocytokines modulate morbidity and outcomes in KTRs.

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Section: Adipocytokines Role In Transplant Comorbiditiesmentioning

confidence: 99%

Adipocytokines in renal transplant recipients

et al. 2016

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“…Some platelet agonist studies have demonstrated improved platelet aggregation post-transplant with some, but not all, agonists [ 11–13 ]. Other groups did not demonstrate increased platelet aggregation with ADP, epinephrine, ristocetin or collagen [ 14–16 ].…”

Section: Introductionmentioning

confidence: 99%

Successful kidney transplantation normalizes platelet function

Kennedy

Wong

Sexton

et al. 2018

Clinical Kidney Journal

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BackgroundUraemic platelet dysfunction is not completely understood, in part due to non-physiological platelet function assays. We have developed a physiological flow-based assay that quantifies platelet function in microlitre volumes of blood under arterial shear. The aim of this study was to characterize platelet function before and after kidney transplantation.MethodsTen patients scheduled for living donor kidney transplant surgery and nine healthy controls were analysed using the assay. The motional parameters of platelet behaviour on von Willebrand factor (VWF) were recorded using customized platelet tracking software. The assay was repeated 3–8 weeks post-transplant in the transplant group and at an interval of >3 weeks in normal healthy volunteers.ResultsPlatelet–VWF interactions were markedly reduced in the 10 pre-transplant patients compared with the healthy controls. In seven patients with immediate graft function, dynamic platelet function returned to normal (despite a small decrease in haemoglobin and haematocrit), but remained markedly abnormal in the three patients with delayed graft function (DGF).ConclusionsDynamic platelet function returned to normal following transplantation in those with immediate graft function. This early improvement was not observed in those with DGF. There may be important clinical implications, as patients with DGF are more likely to undergo invasive procedures, including transplant biopsies and insertion of central venous catheters.

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“…This coincides with a study published in 2015 by Sahin et al . [30] They reported that CSA induces higher adiponectin levels, endothelial dysfunction,[3132] and platelet activation without inducing platelet aggregation[33] in their study. Adiponectin levels were elevated as an endothelial damage marker.…”

Section: Discussionmentioning

confidence: 99%

“…[32] This hypoadiponectinemia could be considered as a compensatory response to endothelial damage induced by CSA administration. [30]…”

Section: Discussionmentioning

confidence: 99%

Renal oxidative stress and inflammatory response in perinatal Cyclosporine-A exposed rat progeny and its relation to gender

El-Bassossy

Hassanien

Bima

et al. 2019

J Microsc Ultrastruct

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Background and Aim of the Work: The current study postulated that cyclosporine A (CSA) could induce gender-specific renal damage. Hence, the current study aims to investigate the nephrotoxic effect of perinatal exposure of male and female rat progeny to CSA. Moreover, it aims to evaluate the oxidative stress and inflammation as a possible pathophysiologic mechanism. Materials and Methods: Female rats were randomly allocated to two groups of four and assigned to undergo either CSA (15 mg/kg/day; the 6 th day after conception and continuing until the progeny were weaned) or vehicle treatment as control groups. At the age of 6 weeks, the progeny were divided into the following four groups: male progeny of control-group mothers (M-vehicle, 7); male progeny of CSA-treated mothers (M-CSA, 9); female progeny of control-group mothers (F-vehicle, 7); and female progeny of CSA-treated mothers (F-CSA, 6). Serum adiponectin, tumor necrosis factor-α (TNF-α) and creatinine, creatinine clearance, and urinary 8-isoprostane were measured. Histopathological examination by hematoxylin and eosin stain of Kidney was carried out. Results: Proteinuria and decreased creatinine clearance are significant in M-CSA than M-vehicle and F-CSA. 8-isoprostane is lower in F-CSA than F-vehicle. Increased TNF-α and decreased adiponectin levels in M-CSA than M-vehicle were observed. No significant differences were found in female rat groups. Conclusion: From the current study, it could be concluded that CSA could induce renal inflammation as well as oxidative stress that may explain the impaired renal function. The sex difference was a prominent finding in their vulnerability to CSA effects.

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Association between endothelial and platelet function markers and adiponectin in renal transplanted recipients on cyclosporine and tacrolimus immunosuppression based therapy

Cited by 6 publications

References 40 publications

Adipocytokines in renal transplant recipients

Adipocytokines in renal transplant recipients

Successful kidney transplantation normalizes platelet function

Renal oxidative stress and inflammatory response in perinatal Cyclosporine-A exposed rat progeny and its relation to gender

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