2008
DOI: 10.1016/j.jash.2007.10.002
|View full text |Cite
|
Sign up to set email alerts
|

Association between endothelial biomarkers and arterial elasticity in young adults: the CARDIA Study

Abstract: Background-Reduced arterial elasticity and endothelial dysfunction both may indicate early cardiovascular (CV) disease in young adults. Pulse waveform analysis estimates large (LAE) and small (SAE) artery elasticity noninvasively. We assessed the associations between LAE and SAE and markers of endothelial dysfunction and CV risk factors.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

2
10
0

Year Published

2010
2010
2016
2016

Publication Types

Select...
6

Relationship

1
5

Authors

Journals

citations
Cited by 12 publications
(12 citation statements)
references
References 44 publications
2
10
0
Order By: Relevance
“…We previously found that in subjects free of cardiovascular risk factors, arterial elasticity increased with age in children, adolescents, and young adults up to age 30, and declined thereafter, particularly after 50 years of age. 18 The age-related decline in arterial elasticity supported previous investigations in adults, 4, 6, 7, 19-21 and was the first to describe an increase in young subjects. 18 Few previous studies have utilized multivariate techniques to evaluate the influence of demographic and risk factor measures on arterial elasticity in different age groups, 4, 8, 20 and none have objectively measured daily physical activity levels as a potential covariate of arterial elasticity.…”
Section: Introductionsupporting
confidence: 82%
See 3 more Smart Citations
“…We previously found that in subjects free of cardiovascular risk factors, arterial elasticity increased with age in children, adolescents, and young adults up to age 30, and declined thereafter, particularly after 50 years of age. 18 The age-related decline in arterial elasticity supported previous investigations in adults, 4, 6, 7, 19-21 and was the first to describe an increase in young subjects. 18 Few previous studies have utilized multivariate techniques to evaluate the influence of demographic and risk factor measures on arterial elasticity in different age groups, 4, 8, 20 and none have objectively measured daily physical activity levels as a potential covariate of arterial elasticity.…”
Section: Introductionsupporting
confidence: 82%
“…These findings agree with previous reports showing that elevated blood pressure reduces both LAEI and SAEI in subjects between 25 and 89 years of age, 1 and in subjects between 27 and 42 years of age in the CARDIA Study. 4 However, not all studies consistently show these trends. 6-8 The strength of association between diastolic blood pressure and SAEI in the current study is noteworthy, as diastolic pressure explained 40% of the variance in SAEI after adjustment for other covariates, suggesting that our subjects between 21 and 50 years of age had high peripheral resistance.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…The procedures for obtaining a BP waveform are consistent with established protocols using this technique in large CVD cohorts [16, 18, 21, 25]. Participants are instructed to avoid caffeine, alcohol, nicotine, antihistamines, and nonsteroidal anti-inflammatory drugs before the study visit.…”
Section: Methodsmentioning
confidence: 99%